LTA
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Official Full Name
lymphotoxin alpha (TNF superfamily, member 1) -
Overview
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin''''s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
LTA;lymphotoxin alpha (TNF superfamily, member 1);LT;TNFB;TNFSF1;lymphotoxin alpha;OTTHUMP00000165897;tumor necrosis factor beta;Tumor necrosis factor ligand superfamily member 1;TNF-beta;LT-alpha
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Rat
- Dog
- Pig
- Rabbit
- S.aureus
- Bacillus subtilis
- HEK293
- E.coli
- HEK293 cells
- Hordeum Vulgare
- Human Cell
- Mammalian Cell
- Insect Cell
- Human
- Mouse
- HEK293T
- Mammalian cells
- Wheat Germ
- Human cells
- In Vitro Cell Free System
- Non
- His
- His&Avi
- HQ
- StrepII
- His&T7
- Myc&DDK
- His&Fc&Avi
- Flag
- His&Myc
- GST
- His&Flag&StrepII
- N-His-Avi
Involved Pathway
LTA involved in several pathways and played different roles in them. We selected most pathways LTA participated on our site, such as Cytokine-cytokine receptor interaction,NF-kappa B signaling pathway,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | PDGFRB,CRTC1,FZD10,MSX2,PPP3CA,MAPK8,MYBL1,MYBL2,PIK3CA,RB1 |
| TNF signaling pathway | NFKB1,RIPK1,MAPK3,PIK3CA,MAP3K5,MAPK10,TAB2,DNM1L,MAPK13,CFLAR |
| Cytokine-cytokine receptor interaction | LOC100033925,IL5,Il2,CX3CL1,CSF2,CCL20A.3,CCL15,IFNB1,IL20RA,IL12RB1 |
| Type I diabetes mellitus | H2-AA,INS1,Il2,IL1B,IFNG,HLA-E,PTPRN2,HLA-DRB1,HLA-DPA1,Fasl |
| NF-kappa B signaling pathway | TNFSF11,LAT,GM13304,NFKBIA,TNFRSF13C,CD40,NFKB1,UBE2I,MAP3K14,ERC1 |
| Herpes simplex infection | HLA-DQA1,HLA-DPA1,TBP,SRSF7,OAS1,SRSF6,C3A.3,EIF2AK1,IFNAR1,OAS2 |
Protein Function
LTA has several biochemical functions, for example, cytokine activity,receptor binding,tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTA itself. We selected most functions LTA had, and list some proteins which have the same functions with LTA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tumor necrosis factor receptor binding | ERAP1,TNFSF10L4,TNFSF13B,Fasl,CD40LG,TRAF4,TRIM37,TRAF6,TRAF2,FADD |
| receptor binding | MTSS1,HCST,GIPC1,ARRB2,CYTL1,HMGCL,CCL13,NRG1,TRDN,FGF10B |
| cytokine activity | GDF11,BMP15,GDF6B,NDP,GREM1,BMP7A,WNT5A,IFNG,GDF2,NAMPT |
Interacting Protein
LTA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTA here. Most of them are supplied by our site. Hope this information will be useful for your research of LTA.
LGALS2;TUBA1A;TNFRSF14;BIRC2;RIPK1
LTA Related Signal Pathway
Resources
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References
- Leroux-Kozal, V; Leveque, N; et al. Merkel cell carcinoma: histopathologic and prognostic features according to the immunohistochemical expression of Merkel cell polyomavirus large T antigen correlated with viral load. HUMAN PATHOLOGY 46:443-453(2015).
- Dammermann, W; Bochmann, D; et al. CMV specific cytokine release assay in whole blood is optimized by combining synthetic CMV peptides and toll like receptor agonists. JOURNAL OF IMMUNOLOGICAL METHODS 414:82-90(2014).
