Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 1)

• Cat.No.: LTA-5067H

Specification

• Species: Human
• Source: Human
• Tag: Non
• roduct Overview: Recombinant human LTAwas expressed in Hi-5 Insect cells and purified by using SDS PAGE and HPLC.
• Description: LTA is a potentmediator of inflammatory and immune responses. It belongs to the TNFsuperfamily of ligands and signals through TNFR1 and TNFR2. LTA is producedby activated T and B lymphocytes, and has similar activities to TNF-alpha.Like TNF-alpha, LTA is involved in the regulation of various biologicalprocesses incuding cell proliferation, differentiation, apoptosis, lipidmetabolism, coagulation, and neurotransmission. LTA is secreted as a solublepolypeptide, but can form heterotrimers with lymphotoxin-beta, whicheffectively anchors the LTA to the cell surface. LTA is cytotoxic to a widerange of tumor cells.
• Form: Lyophilizedfrom 10mM Na3PO4, pH 7.0, with 50 mM NaCl. Reconstitute in Water to aconcentration of 0.1-1.0 mg/ml.
• Purity: >98% pure by SDSPAGE and HPLC
• Sequence: Region of TNF betaprotein corresponding to amino acids GVGLTPSAAQ TARQHPKMHL AHSTLKPAAHLIGDPSKQNS LLWRANTDRA FLQDGFSLSN NSLLVPTSGI YFVYSQVVFS GKAYSPKATS SPLYLAHEVQLFSSQYPFHV PLLSSQKMVY PGLQEPWLHS MYHGAAFQLT QGDQLSTHTD GIPHLVLSPS TVFFGAFAL.
• Molecular Mass: 18.6 kDa
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: LTA

Gene Information

• Gene Name: LTAlymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ]
• Synonyms: LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB;TNFSF1; lymphotoxin-alpha; LT-alpha; TNF-beta; OTTHUMP00000029184;OTTHUMP00000165897; tumor necrosis factor beta; tumor necrosis factor ligandsuperfamily member 1
• Gene ID: 4049
• mRNA Refseq: NM_000595
• Protein Refseq: NP_000586
• MIM: 153440
• UniProt ID: P01374
• Chromosome Location: 6p21.3
• Pathway: Apoptosis;Cytokine-cytokine receptor interaction; HTLV-I infection; Herpes simplexinfection; IL2 signaling events mediated by STAT5; IL4-mediated signalingevents; Type I diabetes mellitus
• Function: cytokineactivity; receptor binding; tumor necrosis factor receptor binding