Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 2), His-tagged

• Cat.No.: LTA-5068H

Specification

• Species: Human
• Source: Human
• Tag: His
• roduct Overview: Recombinant LTAprotein was expressed in E. coli and purified by using conventionalchromatography techniques.
• Description: LTA, a member of thetumor necrosis factor family, is a cytokine produced by lymphocytes. Theprotein is highly inducible, secreted, and forms heterotrimers withlymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. Thisprotein also mediates a large variety of inflammatory, immunostimulatory, andantiviral responses, is involved in the formation of secondary lymphoidorgans during development and plays a role in apoptosis.
• Concentration: 0.5 mg/ml
• Form: Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 30% glycerol, 0.1MNaCl, and 1mM DTT.
• Purity: > 90% by SDS -PAGE
• Sequence: 35-205 amino acids:MGSSHHHHHH SSGLVPRGSH MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANTDRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQKMVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL
• Molecular Mass: 20.9 kDa(192aa), confirmed by MALDI-TOF.
• Applications: SDS-PAGE
• Storage: Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: LTA

Gene Information

• Gene Name: LTAlymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ]
• Synonyms: LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB;TNFSF1; lymphotoxin-alpha; LT-alpha; TNF-beta; OTTHUMP00000029184;OTTHUMP00000165897; tumor necrosis factor beta; tumor necrosis factor ligandsuperfamily member 1
• Gene ID: 4049
• mRNA Refseq: NM_000595
• Protein Refseq: NP_000586
• MIM: 153440
• UniProt ID: P01374
• Chromosome Location: 6p21.3
• Pathway: Apoptosis;Cytokine-cytokine receptor interaction; HTLV-I infection; Herpes simplexinfection; IL2 signaling events mediated by STAT5; IL4-mediated signaling events;Type I diabetes mellitus
• Function: cytokineactivity; receptor binding; tumor necrosis factor receptor binding