HMGB1
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Official Full Name
high mobility group box 1 -
Overview
HMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1,Identified as a membrane associated protein termed “amphoterin,” mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice. -
Synonyms
HMGB1;high mobility group box 1;high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1;high mobility group protein B1;Amphoterin;DKFZp686A04236;high mobility group protein 1;HMG3;SBP 1;Sulfoglucuronyl carbohydrate binding protein;HMG-1;high-mobility group box 1;high-mobility group (nonhistone chromosomal) protein 1;HMG1;SBP-1
Recombinant Proteins
- Mouse
- Human
- Rat
- Calf
- Rhesus macaque
- Cynomolgus
- Chicken
- E.coli
- CHO
- HEK293
- Calf Thymus
- Sf9 Insect Cell
- Mammalian Cell
- Human Cell
- Wheat Germ
- Hi-5 Inscet Cell
- HEK293T
- Yeast
- Mammalian cells
- In Vitro Cell Free System
- HEK293F
- His
- Fc
- Non
- StrepII
- N-His&C-hFc
- GST
- Myc&DDK
- His&Fc&Avi
- His&Myc
- N-His-SUMO
- MARI
- mIgG2a
- N-hFc-Flag-Myc
- Flag
Involved Pathway
HMGB1 involved in several pathways and played different roles in them. We selected most pathways HMGB1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | LIG3,nth,POLD3,POLD4,MUTYH,UNGA,UNG,xthA,PARP3,HMGB1A |
Protein Function
HMGB1 has several biochemical functions, for example, C-X-C chemokine binding,DNA binding, bending,DNA polymerase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB1 itself. We selected most functions HMGB1 had, and list some proteins which have the same functions with HMGB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| supercoiled DNA binding | RPS3,HMGB2,PSIP1 |
| DNA binding, bending | HMGB2,FOXD4,SRY,HMGB3,FOXD1,FOXL1,HMGA2,CRIP1,LEF1,TOP2B |
| C-X-C chemokine binding | CXCR7,CXCR3,CXCR6 |
| protein binding | TAB1,CAMK2B,CCBE1,ESRRA,RPLP2,SDC1,CUL4A,MRPL20,AHSA2,CROP |
| repressing transcription factor binding | HDAC4,SKI,PARK7,CBX5,NOC2L,CTNNB1,GMNN,HDAC9,RUNX2,HDAC7 |
| chromatin binding | ZGLP1,POLG,NCAPD3,SOX10,PHF21B,CHAF1A,YBX1,CBFA2T3,PPARG,SIRT7 |
| damaged DNA binding | NEIL3,EP300,MPG,XRCC1,ERCC4,CREBBP,UNG,OGG1,TP53,RBBP8 |
| double-stranded RNA binding | ADARB1,OAS1A,EIF2AK2,AGO3,MSN,CLTC,STAU2,STAU1,STRBP,OAS2 |
| chemoattractant activity | VHL,VEGFC,CCL16,CXCL12B,BMP4,FGF10,CXCL12A,HGF,VEGFB,FGF2 |
Interacting Protein
HMGB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB1.
HTT;AGTRAP;MSH2;CSNK1A1
Resources
Research Area
Transcription Factors in the Akt PathwayCancer Stem Cell Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
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References
- Roudier, M; Li, XD; et al. Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury. ARTHRITIS AND RHEUMATISM 65:721-731(2013).
- Takaishi, H; Kanai, T; et al. Anti-high mobility group box 1 and box 2 non-histone chromosomal proteins (HMGB1/HMGB2) antibodies and anti-Saccharomyces cerevisiae antibodies (ASCA): accuracy in differentially diagnosing UC and CD and correlation with inflammatory bowel disease phenotype. JOURNAL OF GASTROENTEROLOGY 47:969-977(2012).
