Recombinant Human HMGB1, His-tagged

• Cat.No.: HMGB1-29332TH
• Product Overview: Recombinant full length Human HMGB1 with an N-terminal histidine tag.M.Wt 25 kDa.

Specification

• Product Overview: Recombinant full length Human HMGB1 with an N-terminal histidine tag.M.Wt 25 kDa.
• Description: High-mobility group protein B1, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitution of 1 vial with 1 ml of water to result with solution containing 20 mM HEPES buffer, pH 7.8, 150 mM NaCl, 0.2 mM EDTA, 0.1 % TRITON X-100, 2 mg/ml leupeptin, and 0.1 mM AEBSF.
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 0.1% Triton-X-100, 2mg/ml Leupeptin, 20mM HEPES, 150mM Sodium chloride, 0.2mM EDTA, 0.1mM AEBSF, pH 7.8
• Storage: Store at +4°C. Aliquot and store at -20°C or -80°C when reconstituted. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the HMGB family.Contains 2 HMG box DNA-binding domains.
• Full Length: Full L.

Gene Information

• Gene Name: HMGB1 high mobility group box 1 [ Homo sapiens ]
• Official Symbol: HMGB1
• Synonyms: HMGB1; high mobility group box 1; high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1; high mobility group protein B1; Amphoterin; DKFZp686A04236; high mobility group protein 1; HMG3; SBP 1; Sulfoglucuronyl carbohydr
• Gene ID: 3146
• mRNA Refseq: NM_002128
• Protein Refseq: NP_002119
• MIM: 163905
• Uniprot ID: P09429
• Chromosome Location: 13q12
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of DNA fragmentation factor, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem
• Function: DNA bending activity; DNA bending activity; DNA binding; RAGE receptor binding; calcium-dependent protein kinase regulator activity