Lag3

  • Official Full Name

    lymphocyte-activation gene 3

  • Overview

    Lymphocyte-activation protein 3 belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relati

  • Synonyms

    LAG3;lymphocyte-activation gene 3;lymphocyte activation gene 3 protein;Ly66;CD223;LAG-3

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Cynomolgus
  • Canine
  • Marmoset
  • HEK293
  • CHO
  • Mammalian cells
  • CHO cells
  • Wheat Germ
  • E.coli
  • Mammalian Cell
  • Human Cell
  • HEK293F
  • Human Cells
  • Human cells
  • In Vitro Cell Free System
  • E.coli expression system
  • Fc
  • His
  • His&Avi
  • Fc&Avi
  • Non
  • mFc
  • His&Flag
  • GST
  • His&T7
  • Flag
  • His&Fc&Avi
  • lIgG2b
  • MIgG2a&Avi
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
LAG3-1830H Recombinant Human LAG3 protein, hFc-tagged HEK293 Human Fc Leu23-Leu450
LAG3-104H Active Recombinant Human LAG3 protein, His-tagged HEK293 Human His 23-450 a.a.
Lag3-1831M Active Recombinant Mouse Lag3 protein(Met1-Leu442), His-tagged HEK293 Mouse His Met1-Leu442
Lag3-1832R Recombinant Rat Lag3 protein, His-tagged HEK293 Rat His AA Gly 24 - Leu 442
Lag3-366M Active Recombinant Mouse Lag3 protein(Met1-Leu442), hFc-tagged HEK293 Mouse Fc Met1-Leu442
LAG3-381H Active Recombinant Human LAG3 Protein (Leu 23 - Leu 450), His-tagged, low endotoxin HEK293 Human His Leu 23 - Leu 450
LAG3-384H Active Recombinant Human LAG3 Protein, His & Avi-tagged, Biotinylated HEK293 Human His&Avi Leu 23 - Leu 450
LAG3-386H Active Recombinant Human LAG3 Protein, Fc & Avi-tagged, Biotinylated HEK293 Human Fc&Avi Leu 23 - Leu 450
Lag3-39RAF488 Recombinant Rat Lag3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Rat His 430
Lag3-39RAF555 Recombinant Rat Lag3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Rat His 430
Lag3-39RAF647 Recombinant Rat Lag3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Rat His 430
Lag3-39RF Recombinant Rat Lag3 Protein, His-tagged, FITC conjugated HEK293 Rat His 430
LAG3-467H Recombinant Human LAG3 protein(Met1-Arg440) HEK293 Human Non Met1-Arg440
LAG3-467HAF488 Recombinant Human LAG3 Protein, Met-tagged, Alexa Fluor 488 conjugated HEK293 Human Met1-Arg440， 412
LAG3-467HAF555 Recombinant Human LAG3 Protein, Met-tagged, Alexa Fluor 555 conjugated HEK293 Human Met1-Arg440， 412
LAG3-467HAF647 Recombinant Human LAG3 Protein, Met-tagged, Alexa Fluor 647 conjugated HEK293 Human Met1-Arg440， 412
LAG3-467HF Recombinant Human LAG3 Protein, Met-tagged, FITC conjugated HEK293 Human Met1-Arg440， 412
LAG3-783HAF488 Recombinant Human LAG3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 660
LAG3-783HAF555 Recombinant Human LAG3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 660
LAG3-783HAF647 Recombinant Human LAG3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 660
LAG3-783HF Recombinant Human LAG3 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 660
LAG3-102H Active Recombinant Human LAG3, Fc-tagged CHO Human Fc
LAG3-1828C Active Recombinant Cynomolgus LAG3 protein, Fc-tagged HEK293 Cynomolgus Fc 18-449 a.a.
LAG3-1829C Active Recombinant Cynomolgus LAG3 protein, Fc-tagged HEK293 Cynomolgus Fc AA Ala 18 - His 449
LAG3-5675H Active Recombinant Human Lymphocyte-Activation Gene 3, Fc-tagged Mammalian cells Human His 23-450 a.a.
LAG3-0353C Active Recombinant Cynomolgus LAG3 protein, His-tagged HEK293 Cynomolgus His 18-449 a.a.
LAG3-0354C Active Recombinant Cynomolgus LAG3 protein, His-Avi-tagged, Biotinylated HEK293 Cynomolgus His&Avi 18-449 a.a.
LAG3-051H Active Recombinant Human LAG3 protein, Fc/Avi-tagged, Biotinylated CHO cells Human Fc&Avi Leu23-Leu450
LAG3-1013C Active Recombinant Cynomolgus LAG3 protein, His-tagged HEK293 Cynomolgus His Met1-Leu450, 74 Pro
LAG3-113H Active Recombinant Human LAG3 protein, His-tagged HEK293 Human His Leu 23 - Leu 450
LAG3-1143M Recombinant Mouse LAG3 protein(Met1-Arg432), His-tagged HEK293 Mouse His Met1-Arg432
LAG3-1260M Acitve Recombinant Mouse LAG3 protein(Met1-Leu442) HEK293 Mouse Non Met1-Leu442
LAG3-380C Active Recombinant Cynomolgus LAG3 protein, mFc-tagged, Biotinylated HEK293 Cynomolgus mFc 18-449 a.a.
LAG3-6744H Recombinant Human LAG3 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Leu23-Gly434
LAG3-058H Recombinant Human LAG3 Protein, DDK/HIS-tagged HEK293 Human His&Flag 29-450 a.a.
LAG3-101H Recombinant Human LAG3 Wheat Germ Human Non
LAG3-103H Recombinant Human LAG3, GST-tagged Wheat Germ Human GST
LAG3-15H Active Recombinant Human LAG3 protein(Met1-Leu450), mFc-tagged HEK293 Human mFc Met1-Leu450
LAG3-1776H Recombinant Human LAG3 protein, His & T7-tagged E.coli Human His&T7 Thr244~Glu487
Lag3-1777M Recombinant Mouse Lag3 protein, His & T7-tagged E.coli Mouse His&T7 Leu274~Gln504
Lag3-1778R Recombinant Rat Lag3 protein, His & T7-tagged E.coli Rat His&T7 Asn209~Leu451
Lag3-2089M Recombinant Mouse Lymphocyte-Activation Gene 3, Fc Chimera CHO Mouse Non
LAG3-3344R Recombinant Rat LAG3 Protein Mammalian Cell Rat His
Lag3-389M Active Recombinant Mouse Lag3, Fc-tagged CHO Mouse Fc
Lag3-39R Active Recombinant Rat Lag3 protein(Met1-Leu442), His-tagged HEK293 Rat His Met1-Leu442
LAG3-8925M Recombinant Mouse Lag3 protein, His-tagged HEK293 Mouse His Gly 24 - Leu 442
LAG3-941RCL Recombinant Rat LAG3 cell lysate Human Cell Rat Non
LAG3-0352C Recombinant Canine LAG3 protein, His-tagged HEK293 Canine His 23-440 a.a.
LAG3-0355M Recombinant Mouse LAG3 protein, His-Avi-tagged, Biotinylated HEK293 Mouse His&Avi 24-442 a.a.
LAG3-1011C Recombinant Cynomolgus LAG3 Protein (Met1-Leu450), His-tagged HEK293 Cynomolgus His Met1-Leu450
LAG3-1012C Recombinant Cynomolgus LAG3 protein (Met1-Leu450), His-tagged HEK293 Cynomolgus His 1-450 a.a.
Lag3-1083M Recombinant Mouse Lag3 protein, His-tagged HEK293 Mouse His Ser23-Leu442
Lag3-1084R Recombinant Rat Lag3 Protein, His-tagged HEK293F Rat His Gly24-Leu442
LAG3-151H Recombinant Human LAG3 Protein, DYKDDDDK-tagged Human Cells Human Flag
LAG3-152H Recombinant Human LAG3 Protein, His-tagged Human cells Human His Leu23-Leu450
LAG3-153H Recombinant Human LAG3 Protein, His-tagged Human cells Human His Leu23-Ser252
Lag3-1727M Recombinant Mouse Lag3 Protein, His-tagged E.coli Mouse His Ser23-Leu442
LAG3-196H Recombinant Human LAG3 Protein, His\Avi-tagged Human Cell Human His&Avi 23-450 a.a.
LAG3-2147H Active Recombinant Human LAG3 protein, Biotinylated HEK293 Human Non Met1-Arg440
LAG3-225H Recombinant Human LAG3 Protein (ECD), His-tagged(C-ter) HEK293 Human His Leu23-Leu450
LAG3-2383H Recombinant Human LAG3 Protein, His-tagged E.coli Human His Leu23-Leu450
LAG3-24H Recombinant Human LAG3 Protein, C-6His-Avi tagged, Biotinylated Human Cell Human His&Avi Leu23-Leu450
LAG3-269HF Recombinant Full Length Human LAG3 Protein In Vitro Cell Free System Human Full L.
LAG3-3000R Recombinant Rat LAG3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
LAG3-3000R-B Recombinant Rat LAG3 Protein Pre-coupled Magnetic Beads HEK293 Rat
LAG3-3141H Recombinant Human LAG3 Protein (Leu23-Leu450), His tagged E.coli Human His Leu23-Leu450
LAG3-3324H Recombinant Human LAG3 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
LAG3-3324H-B Recombinant Human LAG3 Protein Pre-coupled Magnetic Beads HEK293 Human
LAG3-382H Active Recombinant Human LAG3 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 Human lIgG2b Leu 23 - Leu 450
LAG3-383H Active Recombinant Human LAG3 Protein, mFc-tagged HEK293 Human mFc Leu 23 - Leu 450
LAG3-385H Active Recombinant Human LAG3 Protein, MIgG2a Fc & Avi-tagged, Biotinylated HEK293 Human MIgG2a&Avi Leu 23 - Leu 450
LAG3-387M Active Recombinant Marmoset LAG3 Protein, His-tagged HEK293 Marmoset His Ala 18 - His 449
LAG3-4400H Recombinant Human LAG3 Protein (Met1-Leu450), C-His tagged Mammalian cells Human His Met1-Leu450
LAG3-4401H Recombinant Human LAG3 protein, His-tagged HEK293 Human His Leu23-Gly434
LAG3-467HB Recombinant Human LAG3 protein, Biotinylated HEK293 Human 1-440 a.a.
Lag3-5709M Recombinant Mouse Lag3 Protein (Ser23-Leu442), C-His tagged Mammalian cells Mouse His Ser23-Leu442
LAG3-616H Recombinant Human LAG3 Protein (29-450 aa), His-GST-tagged E.coli Human His&GST 29-450 aa
LAG3-673M Active Recombinant Mouse LAG3 protein(Met1-Arg432), hFc-tagged HEK293 Mouse Fc Met1-Arg432
LAG3-674M Recombinant Mouse LAG3 Protein, IgG2a Fc-tagged HEK293 Mouse Fc 521
LAG3-675H Recombinant Human LAG3 Protein HEK293 Human 525
LAG3-676H Recombinant Human LAG3 Protein, IgG2a Fc-tagged HEK293 Human Fc 525
LAG3-677H Recombinant Human LAG3 Protein, Fc-tagged HEK293 Human Fc 525
LAG3-678M Recombinant Mouse LAG3 Protein HEK293 Mouse 521
LAG3-679R Recombinant Rat LAG3 Protein HEK293 Rat 525
RFL10567HF Recombinant Full Length Human Lymphocyte Activation Gene 3 Protein(Lag3) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (23-525)

    Involved Pathway

    Lag3 involved in several pathways and played different roles in them. We selected most pathways Lag3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Lag3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    Lag3 has several biochemical functions, for example, MHC class II protein binding,antigen binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Lag3 itself. We selected most functions Lag3 had, and list some proteins which have the same functions with Lag3. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein binding CD74,MARCH8,KRT17,CD74A,CD4,CD74B
    antigen binding TOPORS,IgG3,MHC1UKA,TGFB1,SLAMF1,IGKV1-5,Ighg,LILRA1,SPON2,IL7R
    transmembrane signaling receptor activity CD3E,NRXN1, Cd79b,LILRA1,GPR113,NCR2,TLR10,OR115-6,TLR18,KIR2DL4

    Interacting Protein

    Lag3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lag3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Lag3.

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    Resources

    Research Area

    Cancer Drug Targets
    T Cell Antigen Recognition
    Co-stimulatory Molecules
    Immune Checkpoints

    References

    • Okamura, T; Sumitomo, S; et al. TGF-beta 3-expressing CD4(+)CD25(-)LAG3(+) regulatory T cells control humoral immune responses. NATURE COMMUNICATIONS 6:-(2015).
    • Hannani, D; Vetizou, M; et al. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. CELL RESEARCH 25:208-224(2015).

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