Recombinant Human LAG3 Protein, C-6His-Avi tagged, Biotinylated

• Cat.No.: LAG3-24H
• Product Overview: Biotinylated Recombinant Human Lymphocyte Activation Gene 3 Protein is produced by our Mammalian expression system and the target gene encoding Leu23-Leu450 is expressed with a 6His, Avi tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: Avi&His
• Protein Length: Leu23-Leu450
• Description: Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
• Endotoxin: Less than 0.1 ng/μg (1 EU/μg)
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Shipping: Ambient

Gene Information

• Gene Name: LAG3 lymphocyte-activation gene 3 [ Homo sapiens (human) ]
• Official Symbol: LAG3
• Synonyms: Lymphocyte activation gene 3 protein; LAG3; LAG-3; Protein FDC; CD223
• Gene ID: 3902
• mRNA Refseq: NM_002286
• Protein Refseq: NP_002277
• MIM: 153337
• UniProt ID: P18627