Recombinant Mouse Lag3 Protein, His-tagged

• Cat.No.: Lag3-1727M
• Product Overview: Recombinant Mouse Lag3 Protein (Ser23-Leu442) with N-His tag was expressed in E. coli.

Specification

• Species: Mouse
• Source: E.coli
• Tag: His
• Protein Length: Ser23-Leu442
• Description: Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3).
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 48.7 kDa
  Accurate Molecular Mass: 47 kDa
• Purity: > 80%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Lag3 lymphocyte-activation gene 3 [ Mus musculus (house mouse) ]
• Official Symbol: Lag3
• Synonyms: LAG3; lymphocyte-activation gene 3; lymphocyte activation gene 3 protein; Ly66; CD223; LAG-3
• Gene ID: 16768
• mRNA Refseq: NM_008479
• Protein Refseq: NP_032505
• UniProt ID: Q61790