Recombinant Rat Lag3 Protein, His-tagged

• Cat.No.: Lag3-1084R
• Product Overview: Recombinant Rat Lag3 Protein (Gly24-Leu442) with His tag was expressed in 293F.

Specification

• Species: Rat
• Source: HEK293
• Tag: His
• Protein Length: Gly24-Leu442
• Description: Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3).
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 47.3 kDa; Accurate Molecular Mass: 55 kDa
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Lag3 lymphocyte-activation gene 3 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Lag3
• Synonyms: LAG3; lymphocyte-activation gene 3; lymphocyte activation gene 3 protein; LAG-3; CD223; MGC108901
• Gene ID: 297596
• mRNA Refseq: NM_212513
• Protein Refseq: NP_997678
• UniProt ID: Q5BK54