Active Recombinant Mouse Lag3, Fc-tagged

• Cat.No.: Lag3-389M
• Product Overview: The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Description: Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
• Form: Liquid. In PBS.
• Bio-activity: Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
• Molecular Mass: ~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at +4°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: Lag3 lymphocyte-activation gene 3 [ Mus musculus ]
• Official Symbol: Lag3
• Synonyms: LAG3; lymphocyte-activation gene 3; lymphocyte activation gene 3 protein; Ly66; CD223; LAG-3
• Gene ID: 16768
• mRNA Refseq: NM_008479
• Protein Refseq: NP_032505
• Function: MHC class II protein binding; MHC class II protein binding; transmembrane signaling receptor activity