CD28

  • Official Full Name

    CD28 CD28 molecule

  • Synonyms

    CD28;CD28 molecule;CD28 antigen (Tp44);T-cell-specific surface glycoprotein CD28;T cell specific surface glycoprotein;CD28 antigen;Tp44;MGC138290

Recombinant Proteins

  • Human
  • Rat
  • Human / Cynomolgus / Rhesus macaque
  • Mouse
  • Monkey
  • Human/Cynomolgus/Rhesus macaque
  • Cynomolgus
  • Human/Cynomolgus/Rhesus
  • Chicken
  • Rhesus macaque
  • Human/Cynomolgus/Rhesus Macaque
  • Human/Cynomolgus
  • Canine
  • Felis catus
  • Oryctolagus cuniculus (Rabbit)
  • Mus musculus
  • HEK293
  • Insect Cell
  • CHO
  • Human Cell
  • CHO cells
  • Wheat Germ
  • Mammalian Cell
  • Mammalian cells
  • E.coli
  • Human Cells
  • In Vitro Cell Free System
  • HEK293F
  • E.coli expression system
  • Fc&Avi
  • His&Fc
  • Fc
  • His
  • Non
  • LEVLFQ
  • C-His&Avi
  • mFc
  • N-His-Avi
  • His&Flag&StrepII
  • GST
  • His&Flag
  • His&GST
  • His&Fc&Avi
  • N-His-SUMO
  • His&SUMO
  • His&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CD28-3908H Active Recombinant Human CD28 Protein, Fc & Avi-tagged, Biotinylated HEK293 Human Fc&Avi Asn 19 - Pro 152
CD28-01H Active Recombinant Human CD28 protein, hIgG-His-tagged Insect Cell Human His&Fc 19-152aa
CD28-1099R Recombinant Rat CD28 Protein, Fc-tagged HEK293 Rat Fc 1-149 a.a.
CD28-1100R Recombinant Rat CD28 Protein, His-tagged HEK293 Rat His 1-149 a.a.
CD28-321H Recombinant Human CD28 Protein HEK293 Human Non 1-152 a.a.
CD28-32H Active Recombinant Human CD28 protein, Biotin-labelled CHO Human Non
CD28-3909H Recombinant Human / Cynomolgus / Rhesus macaque CD28 protein(Asn 19 - Pro 152), C-hFc-tagged HEK293 Human / Cynomolgus / Rhesus macaque Fc 1-152 a.a.
CD28-3910H Recombinant Human CD28, His tagged Human Cell Human His 1-152 a.a.
Cd28-4008M Recombinant Mouse Cd28 protein, His-tagged HEK293 Mouse His Asn20-Lys149
CD28-640M Recombinant Mouse CD28, Fc-His tagged Human Cell Mouse His&Fc 1-149 a.a.
CD28-1099RAF488 Recombinant Rat CD28 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Rat Fc 371
CD28-1099RAF555 Recombinant Rat CD28 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Rat Fc 371
CD28-1099RAF647 Recombinant Rat CD28 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Rat Fc 371
CD28-1099RF Recombinant Rat CD28 Protein, Fc-tagged, FITC conjugated HEK293 Rat Fc 371
CD28-1100RAF488 Recombinant Rat CD28 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Rat His 141
CD28-1100RAF555 Recombinant Rat CD28 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Rat His 141
CD28-1100RAF647 Recombinant Rat CD28 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Rat His 141
CD28-1100RF Recombinant Rat CD28 Protein, His-tagged, FITC conjugated HEK293 Rat His 141
CD28-1204CAF488 Recombinant Monkey CD28 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Monkey Fc 372
CD28-1204CAF555 Recombinant Monkey CD28 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Monkey Fc 372
CD28-1204CAF647 Recombinant Monkey CD28 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Monkey Fc 372
CD28-1204CF Recombinant Monkey CD28 Protein, Fc-tagged, FITC conjugated HEK293 Monkey Fc 372
CD28-321HAF488 Recombinant Human CD28 Protein, Alexa Fluor 488 conjugated HEK293 Human LEVLFQ 141
CD28-321HAF555 Recombinant Human CD28 Protein, Alexa Fluor 555 conjugated HEK293 Human LEVLFQ 141
CD28-321HAF647 Recombinant Human CD28 Protein, Alexa Fluor 647 conjugated HEK293 Human LEVLFQ 141
CD28-321HF Recombinant Human CD28 Protein, FITC conjugated HEK293 Human LEVLFQ 141
CD28-337H Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, His-tagged HEK293 Human/Cynomolgus/Rhesus macaque His 134
CD28-339M Recombinant Mouse CD28 protein, Fc-tagged HEK293 Mouse Fc 130
CD28-3909HAF488 Recombinant Human CD28 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 375
CD28-3909HAF555 Recombinant Human CD28 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 375
CD28-3909HAF647 Recombinant Human CD28 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 375
CD28-3909HF Recombinant Human CD28 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 375
Cd28-4008MAF488 Recombinant Mouse Cd28 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His Asn20-Lys149
Cd28-4008MAF555 Recombinant Mouse Cd28 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His Asn20-Lys149
Cd28-4008MAF647 Recombinant Mouse Cd28 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His Asn20-Lys149
Cd28-4008MF Recombinant Mouse Cd28 Protein, His-tagged, FITC conjugated HEK293 Mouse His Asn20-Lys149
CD28-640MAF488 Recombinant Mouse CD28 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His&Fc 378
CD28-640MAF555 Recombinant Mouse CD28 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His&Fc 378
CD28-640MAF647 Recombinant Mouse CD28 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His&Fc 378
CD28-640MF Recombinant Mouse CD28 Protein, Fc/His-tagged, FITC conjugated HEK293 Mouse His&Fc 378
CD28-1204C Active Recombinant Cynomolgus CD28 protein(Met1-Pro152), hFc-tagged HEK293 Cynomolgus Fc Met1-Pro152
CD28-212H Active Recombinant Human CD28, MIgG2a Fc-tagged CHO Human Fc 19-152 a.a.
CD28-232M Active Recombinant Mouse CD28, MIgG2a Fc-tagged CHO Mouse Fc 21-149 a.a.
CD28-378H Active Recombinant Human CD28, HIgG1 Fc-tagged CHO Human Fc 19-152 a.a.
CD28-566H Active Recombinant Human CD28, Fc-tagged, Biotinylated Human Cell Human Fc 19-152 a.a.
CD28-051H Active Recombinant Human CD28 protein, Fc/Avi-tagged, Biotinylated CHO cells Human Fc&Avi Asn19-Pro152
CD28-1056H Recombinant Human/Cynomolgus/Rhesus CD28 protein(Met1-Pro152), His&Avi-tagged, Biotinylated HEK293 Human/Cynomolgus/Rhesus C-His&Avi Met1-Pro152
CD28-336H Active Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, mFc-tagged, low endotoxin HEK293 Human mFc Asn 19 - Pro 152
CD28-338H Active Recombinant Human / Cynomolgus / Rhesus Monkey CD28 Protein, Fc & Avi-tagged, Biotinylated HEK293 Human / Cynomolgus / Rhesus macaque Fc&Avi Asn 19 - Pro 152
CD28-5744H Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, His-Avi-tagged HEK293 Human/Cynomolgus/Rhesus macaque N-His-Avi Asn19-Pro152
CD28-8665H Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, His-Avi-tagged, Biotinylated HEK293 Human/Cynomolgus/Rhesus macaque N-His-Avi Asn19-Pro152
CD28-0772H Recombinant Human CD28 Protein Wheat Germ Human Non
CD28-0773H Recombinant Human CD28 Protein, His-Flag-StrepII-Tagged Human Cell Human His&Flag&StrepII 18-152 a.a.
CD28-0774H Recombinant Human CD28 Protein, GST-Tagged Wheat Germ Human GST
CD28-1244R Recombinant Rat CD28 Protein Mammalian Cell Rat His
CD28-142H Recombinant Human CD28, Fc-tagged CHO Human Fc 19-152 a.a.
CD28-1593H Recombinant Human CD28 Molecule Mammalian cells Human Non
Cd28-1712M Recombinant Mouse CD28 Antigen, Fc-His Mammalian cells Mouse His&Fc 1-149 a.a.
CD28-181H Recombinant Human CD28 Protein, DDK/His-tagged HEK293 Human His&Flag Asn19-Pro152
CD28-182H Recombinant Human CD28 Protein, Fc-tagged HEK293 Human Fc
CD28-387C Recombinant Cynomolgus CD28 Protein, His-tagged Mammalian Cell Cynomolgus His
Cd28-661M Recombinant Mouse Cd28 protein, His & GST-tagged E.coli Mouse His&GST Asp33~Val174
CD28-6863C Recombinant Chicken CD28 Mammalian Cell Chicken His
CD28-733R Recombinant Rhesus monkey CD28 Protein, His-tagged Mammalian Cell Rhesus macaque His
CD28-2002MCL Recombinant Mouse CD28 cell lysate Human Cell Mouse Non
CD28-2013HCL Recombinant Human CD28 cell lysate Human Cell Human Non
CD28-135C Recombinant Cynomolgus Monkey CD28 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
CD28-135C-B Recombinant Cynomolgus Monkey CD28 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
CD28-1379H Recombinant Human CD28 Protein (Asn19-Pro152), N-His tagged E.coli Human His Asn19-Pro152
CD28-151H Recombinant Human CD28 Protein, His-tagged Human Cells Human His
Cd28-157M Recombinant Mouse Cd28 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Cd28-157M-B Recombinant Mouse Cd28 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CD28-1605H Recombinant Human CD28 Protein (Met1-Pro152), C-Fc tagged Mammalian cells Human Fc Met1-Pro152
CD28-1876R Active Recombinant Rat CD28 protein, His-tagged HEK293 Rat His 20-150 a.a.
CD28-2338M Recombinant Mouse CD28 protein(Met1-Lys149), hFc-tagged HEK293 Mouse Fc Met1-Lys149
CD28-256H Recombinant Human/Cynomolgus/Rhesus Macaque CD28 Protein, Asn19-Pro152, N-His-Avi tagged, Biotinylated HEK293 Human/Cynomolgus/Rhesus Macaque N-His-Avi Asn19-Pro152
Cd28-28M Recombinant Mouse CD28 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Mouse His&Fc Asn20-Lys149
CD28-3092HF Recombinant Full Length Human CD28 Protein In Vitro Cell Free System Human Full L. 473 amino acids
CD28-3095HF Recombinant Full Length Human CD28 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 220 amino acids
CD28-322H Recombinant Human CD28 Protein (Asn19-Pro152), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 Human N-His-SUMO Asn19-Pro152
CD28-332HG Active GMP Recombinant Human CD28 protein, Fc-tagged HEK293 Human Fc DNA sequence encoding Human CD28(GenBank: AAH93698.1) was expressed with Fc tag at the C-terminal.
CD28-339H Recombinant Human/Cynomolgus CD28(Asn19-Pro152) Protein, N-6*His-tagged HEK293 Human/Cynomolgus His 19-152 a.a.
CD28-4376H Recombinant Human CD28 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CD28-4376H-B Recombinant Human CD28 Protein Pre-coupled Magnetic Beads HEK293 Human
CD28-4995H Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein(Asn 19 - Pro 152) HEK293 Human / Cynomolgus / Rhesus macaque Fc Asn 19 - Pro 152
CD28-503M CD28 protein-coupled magnetic MicroBeads Human
CD28-559R Recombinant Rhesus Macaque CD28 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CD28-559R-B Recombinant Rhesus Macaque CD28 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
CD28-562H Recombinant Human/Cynomolgus/Rhesus macaque CD28 protein, Fc-tagged (HPLC-verified) HEK293 Human/Cynomolgus/Rhesus macaque Fc Asn19-Pro152
CD28-5643C Recombinant Canine CD28 protein, mFc-tagged HEK293 Canine mFc Thr18-Pro153
CD28-624M Recombinant Mouse CD28 Protein HEK293 Mouse 218
CD28-625M Recombinant Mouse CD28 Protein, Fc-tagged HEK293 Mouse Fc 218
Cd28-666M Recombinant Mouse Cd28 Protein, His-tagged E.coli Mouse His Asn20-Leu150
CD28-667H Recombinant Human CD28 Protein, His-tagged HEK293F Human His Asn19-Pro152
CD28-668H Recombinant Human CD28 Protein, His&SUMO-tagged HEK293F Human His&SUMO Met1-Pro152
Cd28-669R Recombinant Rat Cd28 Protein, His-tagged E.coli Rat His Asn20-Leu150
CD28-6754C Recombinant Canine CD28 protein, His-tagged HEK293 Canine His Thr18-Pro153
CD28-747H Recombinant Human CD28 protein, His-Avi-tagged HEK293 Human His&Avi It contains Thr17-Pro152.
CD28-747HB Recombinant Human CD28 protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Thr17-Pro152
CD28-902R Recombinant Rat CD28 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CD28-902R-B Recombinant Rat CD28 Protein Pre-coupled Magnetic Beads HEK293 Rat
Kit-1705 CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit Non
RFL10568GF Recombinant Full Length Chicken T-Cell-Specific Surface Glycoprotein Cd28 Homolog(Cd28) Protein, His-Tagged E.coli expression system Chicken His Full L. Full Length of Mature Protein (14-221)
RFL13001FF Recombinant Full Length Cat T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system Felis catus His Full L. Full Length (21-221)
RFL17688RF Recombinant Full Length Rat T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length of Mature Protein (20-218)
RFL24979HF Recombinant Full Length Human T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (19-220)
RFL29096OF Recombinant Full Length Rabbit T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system Oryctolagus cuniculus (Rabbit) His Full L. Full Length of Mature Protein (20-221)
RFL5884MF Recombinant Full Length Mouse T-Cell-Specific Surface Glycoprotein Cd28(Cd28) Protein, His-Tagged E.coli expression system Mus musculus His Full L. Full Length of Mature Protein (20-218)

    Involved Pathway

    CD28 involved in several pathways and played different roles in them. We selected most pathways CD28 participated on our site, such as Cell adhesion molecules (CAMs),T cell receptor signaling pathway,Intestinal i, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Intestinal i HLA-DPA1,TNFRSF17,TGFB1,TNFRSF13B,CCR9A,BMA1,ICOS,CCR10,TNFSF13,CXCR4A
    Measles AKT1,TNFRSF10D,RELA,PRKCQ,CD209A,IFNA13,BBC3,IFNA6,MYD88,TLR4
    Graft-versus-host disease HLA-DRB5,IL6,HLA-E,Fasl,KIR3DL2,FASLG,KIR2DL3,HLA-B,HLA-DMA,HLA-DOA
    Rheumatoid arthritis ANGPT1,HLA-DMB,ITGAL,HLA-DRB1,LTB,HLA-DQA1,HLA-DOA,ATP6V0A4,VEGFA,HLA-DPA1
    Systemic lupus erythematosus HIST1H4H,HIST1H4B,C1R,HIST1H2BQ,HIST2H3C2,HIST1H2BO,HIST1H2AA,HIST3H2BB-PS,CD80,CD40
    Autoi TPO,GZMB,HLA-DRB3,HLA-DRA,IFNA12,HLA-DRB4,IFNA1,IFNA21,Fasl,HLA-DPA1
    Viral myocarditis HLA-F,EIF4G3,CD40,CYCS,HLA-DPB1,RAC3,SGCB,CASP9,ABL1,HLA-DRB3
    T cell receptor signaling pathway PIK3CG,NFATC3,PIK3R1,PAK1,MAPK12,MAP3K7,VAV1,SLA1,GRAPA,NCK1
    Allograft rejection CD80,CD40,HLA-F,FASLG,Fasl,CD40LG,GZMB,IL4,HLA-DOA,HLA-B

    Protein Function

    CD28 has several biochemical functions, for example, SH3/SH2 adaptor activity,coreceptor activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD28 itself. We selected most functions CD28 had, and list some proteins which have the same functions with CD28. You can find most of the proteins on our site.

    Function Related Protein
    protein binding UNC13A,APP,TP53,RAMP3,RSU1,CARD8,HJURP,HNF1A,HIST1H4A,HIF1A
    SH3/SH2 adaptor activity SHB,SH2D3C,BLNK,ITSN2,ARHGAP4,SH2B2,GRAP,SH3BP2,SH2D2A,SH3BGRL
    identical protein binding STK4,CDC42,CAD,ATXN3,ASS1,STK10,DCTPP1,UAP1,ATXN10,ERBB2
    protease binding TIMP2B,TIMP2A,ADAMTSL4,ITGB3,FADD,TNFAIP3,CAST,CD70,DVL3,ADAMTS4
    coreceptor activity PVRL1,ACKR3B,CD86,IGSF1,CCR8,RAMP1,LRP5,CXCR7B,RAMP2,ZP2

    Interacting Protein

    CD28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD28 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD28.

    PIK3R1;GRAP2;CD80;PIK3R1;Pik3r1;GRB2;PRKCQ

    Resources

    Gene Families

    What is immunoglobulin superfamily (IgSF)

    Research Area

    Cancer Drug Targets
    ITIM/ITAM Immunoreceptors and Related Molecules
    B Cell CD Antigen
    B7/CD28 Family
    Cytotoxic T Cells (CTLs)
    Natural Killer T (NKT) Cells
    T Cell Antigen Recognition
    T Cell Markers
    CD Antigen (Dendritic Cell Co-stimulatory Molecules)
    CD Antigen (Regulatory T Cells)
    CD Antigen (T Cell Antigen Recognition)
    Co-stimulatory Molecules
    Thymus-Dependent B Cell Activation
    T Follicular Helper (Tfh) Cells
    Dendritic Cell Co-stimulatory Molecules
    Immune Checkpoints

    References

    • Bakdash, G; Vogelpoel, LTC; et al. Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. MUCOSAL IMMUNOLOGY 8:265-278(2015).
    • Toyota, H; Sudo, K; et al. Thy28 protects against anti-CD3-mediated thymic cell death in vivo. APOPTOSIS 20:444-454(2015).

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