Active Recombinant Human CD28, HIgG1 Fc-tagged
| Cat.No. : | CD28-378H |
| Product Overview : | The extracellular domain of human CD28 (AAA60581.1) (Asn19-Pro152) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell. |
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| Description : | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, andT-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms havebeen found for this gene. |
| Source : | CHO cells |
| Species : | Human |
| Tag : | HIgG1 Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. |
| Molecular Mass : | 41 KDa (monomer) |
| AA Sequence : | Asn19-Pro152 |
| Endotoxin : | <0.06 eu/μg="" as="" determined="" by="" lal="" test.=""> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Protein length : | 19-152 a.a. |
| Gene Name | CD28 CD28 molecule [ Homo sapiens ] |
| Official Symbol | CD28 |
| Synonyms | CD28; CD28 molecule; CD28 antigen (Tp44); T-cell-specific surface glycoprotein CD28; T cell specific surface glycoprotein; CD28 antigen; Tp44; MGC138290; |
| Gene ID | 940 |
| mRNA Refseq | NM_001243077 |
| Protein Refseq | NP_001230006 |
| MIM | 186760 |
| UniProt ID | P10747 |
| Chromosome Location | 2q33 |
| Pathway | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; |
| Function | SH3/SH2 adaptor activity; coreceptor activity; identical protein binding; protease binding; protein binding; protein homodimerization activity; |
Not For Human Consumption!
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