SPP1
-
Official Full Name
secreted phosphoprotein 1 -
Overview
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] -
Synonyms
SPP1;secreted phosphoprotein 1;OPN;BNSP;BSPI;ETA-1;osteopontin;uropontin;nephropontin;SPP1/CALPHA1 fusion;urinary stone protein;early T-lymphocyte activation 1;osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein;secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
Recombinant Proteins
- Human
- Cynomolgus
- Dog
- Mouse
- Rhesus macaque
- Zebrafish
- Rat
- Chicken
- Pig
- Cattle
- Rabbit
- HEK293
- CHO
- Human
- Mammalian cells
- C-His
- E. coli
- Human Cell
- E.coli
- Mammalian Cell
- HEK293F
- Sf9 Insect Cell
- Rabbit
- Yeast
- HEK293T
- His
- Fc
- Non
- StrepII
- MBP
- GST
- Flag
- His&Avi
- His&Fc&Avi
- His&GST
- His&SUMO
- Myc&DDK
- N-His&C-Myc
Involved Pathway
SPP1 involved in several pathways and played different roles in them. We selected most pathways SPP1 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | TNR,FN1,ITGB4,GP9,ITGB5,FN1A,ITGA5,LAMC1,SDC1,COMP |
| Focal adhesion | LAMB4,MAPK8B,SRC,ITGA8,FN1,RAC1,PIK3R3,RAPGEF1,AKT3A,ACTN2B |
| PIK-Akt signaling pathway | IL2RG,FLT1,PPP2R5E,IGF1,YWHAB,ITGA5,RBL2,CCND2,HSP90AA1,TLR2 |
| Toll-like receptor signaling pathway | TLR5,IFNA10,MAPK9,CXCL11,NFKBIAB,RIPK1L,CASP8,MAPK3,LBP,PIK3R2 |
Protein Function
SPP1 has several biochemical functions, for example, cytokine activity,extracellular matrix binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPP1 itself. We selected most functions SPP1 had, and list some proteins which have the same functions with SPP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix binding | DCN,DMP1,TGFBI,SPOCK2,GPR56,FBLN2,VTN,SID4,BGN,CYR61 |
| protein binding | C14orf118,IL11,MED31,PBX1,BTC,ARMCX1,TBCB,LIG3,ADNP,INTS10 |
| cytokine activity | CCL4,TXLNA,TNFSF12,VSTM1,TNFSF11,C1QTNF4,IFNB1,IFNPHI3,CCL20B,IL17B |
Interacting Protein
SPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPP1.
SGTA;CD44;MEOX2;UBQLN4;F2;APOA1;PEPD;BAG6;CTNNBL1;PDLIM7
Resources
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References
- Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
- Gazal, S; Sacre, K; et al. Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
