Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Synonyms
ADIPOQ;adiponectin, C1Q and collagen domain containing;APN;Acdc;apM1;30kDa;GBP28;adipo;Acrp30;adiponectin;adipocyte-specific protein AdipoQ;adipocyte complement related protein;30 kDa adipocyte complement-related protein;adipocyte complement-related 30 kDa protein;adipocyte, C1Q and collagen domain containing;adipocyte, C1q and collagen domain-containing protein
ADIPOQ involved in several pathways and played different roles in them. We selected most pathways ADIPOQ participated on our site, such as PPAR signaling pathway,AMPK signaling pathway,Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADIPOQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
ADIPOQ has several biochemical functions, for example, cytokine activity,hormone activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADIPOQ itself. We selected most functions ADIPOQ had, and list some proteins which have the same functions with ADIPOQ. You can find most of the proteins on our site.
ADIPOQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADIPOQ here. Most of them are supplied by our site. Hope this information will be useful for your research of ADIPOQ.
Cai, X; Gan, Y; et al. The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk. CLINICAL & TRANSLATIONAL ONCOLOGY 16:166-172(2014).
Pang, YF; Dong, J; et al. Characterization, Neurosteroid Binding and Brain Distribution of Human Membrane Progesterone Receptors delta and epsilon (mPR delta and mPR epsilon) and mPR delta Involvement in Neurosteroid Inhibition of Apoptosis. ENDOCRINOLOGY 154:283-295(2013).
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