Active Recombinant Human Adiponectin, C1Q And Collagen Domain Containing

• Cat.No.: ADIPOQ-4957H
• Product Overview: Recombinant human ADIPOQ protein was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: The gAcrp30 variant is a naturally occurring globular protein, obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, Acrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and names AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver.
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of gAcrp30 protein corresponding to amino acids PGAEGPRGFP GIQGRKGEPG EGAYVYRSAF SVGLETYVTI PNMPIRFTKI FYNQQNHYDG STGKFHCNIP GLYYFAYHIT VYMKDVKVSL FKKDKAMLFT YDQYQENNVD QASGSVLLHL EVGDQVWLQV YGEGERNGLY ADNDNDSTFT GFLLYHDTN.
• Molecular Mass: 18.1 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Bioactivity: Determined by a cytotoxicity assay using M1 cells. The expected ED50 for this effect is 0.5-1.0 ug/ml.
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens ]
• Official Symbol: ADIPOQ
• Synonyms: ADIPOQ; adiponectin, C1Q and collagen domain containing; ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1; adiponectin; AdipoQ; apM1; adipose most abundant gene transcript 1; Adiponectin; Adipocyte, C1q and collagen domain-containing protein; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein; Adipose most abundant gene transcript 1 protein; apM-1; Gelatin-binding protein
• Gene ID: 9370
• mRNA Refseq: NM_004797
• Protein Refseq: NP_004788
• MIM: 605441
• UniProt ID: Q15848
• Chromosome Location: 3q27
• Pathway: Adipocytokine signaling pathway; PPAR signaling pathway; Type II diabetes melitus
• Function: cytokine activity; eukaryotic cell surface binding; hormone activity; protein homodimerization activity