LEP
-
Official Full Name
leptin -
Overview
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. -
Synonyms
LEP;leptin;obesity factor;OB;obese;OBS
Recombinant Proteins
- Human
- Ovine
- Rat
- Murine
- Rabbit
- Bovine
- Chicken
- Dog
- Equine
- Mouse
- Pufferfish
- Rhesus macaque
- Pig
- Cattle
- Horse
- E.coli
- Human
- Ovine
- HEK293
- Mammalian Cell
- Mouse
- Human Cell
- HEK293T
- Bacillus subtilis
- Non
- His
- His&S
- StrepII
- His&T7
- His&GST
- Myc&DDK
- His&Fc&Avi
- mFc
Involved Pathway
LEP involved in several pathways and played different roles in them. We selected most pathways LEP participated on our site, such as Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | S1PR2,GRM7,GABRA3,PTGER4,BDKRB2,LTB4R2,VIPR2,P2RX1,TSHB,CCKAR |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFA4L2,UQCR11,NDUFA9,CYCS,GSK3B,NDUFS1,NDUFB6,PIK3R1,NDUFB2,NDUFC2 |
| AMPK signaling pathway | TSC1,STK11,GYS2,ACACA,CREB3L1,CCNA1,ACACB,PPP2R2B,TSC2,G6PC3 |
| Cytokine-cytokine receptor interaction | IL18,IL15,EDAR,IL-8,CCR1L1,EPO,IL7,CCL21B,PDGFC,TNFSF15 |
| Adipocytokine signaling pathway | ADIPOQB,G6PC3,ACSL4B,PRKAA2,JAK2A,NFKBIAA,AKT2L,ACSL3B,PPARGC1A,CD36 |
| Jak-STAT signaling pathway | NT5C3,IL22RA2,GM13305,CNTF,IL12RB2,Il23a,GH2,PIAS4,IL10RB,CISHB |
Protein Function
LEP has several biochemical functions, for example, growth factor activity,hormone activity,peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEP itself. We selected most functions LEP had, and list some proteins which have the same functions with LEP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | SST,UTS2A,ADM2,BMP10,INSL4,CCK,SMTLB,IGF2,TG,RETN |
| peptide hormone receptor binding | JAK2,PTPN11,NPPA,PTH,PTHLHA,PTHLH,ADCYAP1,NPPC,FYN,RUNDC3A |
| growth factor activity | GDF1,JAG2,MDK,JAG1,NDR1,THBS4,VEGFAB,TFF1,COL20A1,FGF10A |
Interacting Protein
LEP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEP here. Most of them are supplied by our site. Hope this information will be useful for your research of LEP.
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