Active Recombinant Murine Lep protein
Cat.No. : | Lep-337M |
Product Overview : | Recombinant Murine Lep was expressed in E. coli. |
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Species : | Murine |
Source : | E.coli |
Tag : | Non |
Protein Length : | 147 amino acid |
Description : | Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. |
Form : | Sterile filtered through a 0.2 micron filter. Lyophilized with 0.1% TFA. |
Bio-activity : | Creative BioMart's murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight. |
Molecular Mass : | 16.2 kDa |
AA Sequence : | MVPIQKVQD DTKTLIKTI VTRINDISH TQSVSAKQR VTGLDFIPG LHPILSLSK MDQTLAVYQ QVLTSLPSQ NVLQIANDL ENLRDLLHL LAFSKSCSL PQTSGLQKP ESLDGVLEA SLYSTEVVA LSRLQGSLQ DILQQLDVS PEC |
Endotoxin : | <0.1 ng/ug of the protein. |
Purity : | Above 98% as determined by SDS-PAGE Analysis. |
Storage : | Stored at -20 centigrade. |
Reconstitution : | Centrifuge the viral prior to opening. Rconstitute in water to a concentration of 1.0-5.0 mg/ml. Do not vortex. For extened storage, it is recommended to further dilute in a buffer containing a carrier protein(example 0.1% BSA) and store in working aliquots at -20 centigrade to -80 centigrade. |
Gene Name | Lep leptin [ Mus musculus ] |
Official Symbol | Lep |
Synonyms | LEP; leptin; obesity factor; ob; obese; |
Gene ID | 16846 |
mRNA Refseq | NM_008493 |
Protein Refseq | NP_032519 |
MIM | |
UniProt ID | P41160 |
Chromosome Location | 6 A3.3; 6 12.3 cM |
Pathway | Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; |
Function | growth factor activity; hormone activity; peptide hormone receptor binding; protein binding; |
◆ Recombinant Proteins | ||
LEP-09D | Recombinant Dog Leptin | +Inquiry |
LEP-336H | Active Recombinant Human Leptin | +Inquiry |
Lep-18M | Recombinant Mouse Leptin, Antagonist Triple Mutant | +Inquiry |
LEP-201H | Recombinant Human LEP Protein | +Inquiry |
LEP-4433H | Recombinant Human LEP Protein (Val22-Cys167), N-His tagged | +Inquiry |
◆ Native Proteins | ||
LEP-27641TH | Native Human LEP | +Inquiry |
◆ Cell & Tissue Lysates | ||
LEP-4773HCL | Recombinant Human LEP 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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