Active Recombinant Murine Lep protein

Cat.No. : Lep-337M
Product Overview : Recombinant Murine Lep was expressed in E. coli.
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Species : Murine
Source : E.coli
Tag : Non
Protein Length : 147 amino acid
Description : Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models.
Form : Sterile filtered through a 0.2 micron filter. Lyophilized with 0.1% TFA.
Bio-activity : Creative BioMart's murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight.
Molecular Mass : 16.2 kDa
AA Sequence : MVPIQKVQD DTKTLIKTI VTRINDISH TQSVSAKQR VTGLDFIPG LHPILSLSK MDQTLAVYQ QVLTSLPSQ NVLQIANDL ENLRDLLHL LAFSKSCSL PQTSGLQKP ESLDGVLEA SLYSTEVVA LSRLQGSLQ DILQQLDVS PEC
Endotoxin : <0.1 ng/ug of the protein.
Purity : Above 98% as determined by SDS-PAGE Analysis.
Storage : Stored at -20 centigrade.
Reconstitution : Centrifuge the viral prior to opening. Rconstitute in water to a concentration of 1.0-5.0 mg/ml. Do not vortex. For extened storage, it is recommended to further dilute in a buffer containing a carrier protein(example 0.1% BSA) and store in working aliquots at -20 centigrade to -80 centigrade.
Gene Name Lep leptin [ Mus musculus ]
Official Symbol Lep
Synonyms LEP; leptin; obesity factor; ob; obese;
Gene ID 16846
mRNA Refseq NM_008493
Protein Refseq NP_032519
MIM
UniProt ID P41160
Chromosome Location 6 A3.3; 6 12.3 cM
Pathway Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem;
Function growth factor activity; hormone activity; peptide hormone receptor binding; protein binding;

Not For Human Consumption!

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