IL3
-
Official Full Name
interleukin 3 -
Overview
The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. -
Synonyms
Colony stimulating factor multiple;Hematopoietic growth factor;IL 3;IL-3;IL3;IL3_HUMAN;Interleukin 3 (colony stimulating factor, multiple);Interleukin 3;Interleukin-3;Mast cell growth factor;MCGF;MGC79398;MGC79399;Multi CSF;Multilineage colony stimulating factor;Multipotential colony stimulating factor;Multipotential colony-stimulating factor;OTTHUMP00000065963;P cell stimulating factor;P-cell-stimulating factor;BPA;PSF;HCGF;Csfmu;nterleukin-3;TTMUSP00000005831;ast cell growth factor
Recombinant Proteins
- Rat
- Human
- Mouse
- Bovine
- Cynomolgus
- Chicken
- Rhesus macaque
- Dog
- Canine
- Insect Cells
- HEK293
- Nicotiana Benthamiana
- CHO
- E.coli
- Mouse
- Hordeum Vulgare
- Yeast
- N-His
- Mammalian Cells
- S.Cerevisiae
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Fc
- Avi&His
- HQ
- GST&His
- His&T7
- Avi&Fc&His
- His&MBP
- GST
Involved Pathway
IL3 involved in several pathways and played different roles in them. We selected most pathways IL3 participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | CD8B1,IL1R2,GP1BA,CD3D, B2M,CD1D2,CSF3,Il4ra,KIT,DNTT |
| Jak-STAT signaling pathway | Il4ra,NT5C3,PIK3R2,AOX3L1,IFNAR1,IL21,CSH1,IFNPHI3,IL5,GHRA |
| Fc epsilon RI signaling pathway | LYN,PRKCA,MAPK13,AKT1,PLA2G4C,BTK,MAPK12,PIK3CG,MAP2K7,MAP2K4 |
| PIK-Akt signaling pathway | EIF4E2,PIK3R5,CCND3,ITGB8,PHLPP2,Kitl,PPP2R5A,ITGA2B,MAPK3,ITGB4 |
| Asthma | HLA-DOA,PRG2,HLA-DQB1,HLA-DRB3,HLA-DRB1,HLA-DRB4,HLA-DQA1,FCER1G,HLA-DRA,CCL11 |
| Cytokine-cytokine receptor interaction | IL9R,GM-CSF,IFNA5,IL19,IFNG,IFNA4,TNFRSF11B,TNFRSF10B,EDA,KITA |
| Transcriptional misregulation in cancer | REL,PROM1,PRCC,ATM,HPGD,HIST2H3C1,NUPR1,MDM2,HIST1H3C,CCNT2 |
| Apoptosis | PIK3R1,MYC,SPNA2,GZMF,CAPN2L,NGF,PRKACBA,IKBKB,PIK3CA,CASP8L1 |
Protein Function
IL3 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-3 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL3 itself. We selected most functions IL3 had, and list some proteins which have the same functions with IL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-3 receptor binding | RNF41 |
| cytokine activity | CMTM1,GM13278,TNFSF4,BMP4,BMP1,TIMP1,VEGFA,IL17D,BMP8B,CD40LG |
| growth factor activity | FGF11,PPBP,LEFTY1,FGF12B,GDF3,CSF2,NTF3,FGF22,MDKA,KLK1B3 |
Interacting Protein
IL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL3.
CSF2RB
IL3 Related Signal Pathway
Resources
Research Area
T Cell Cytokine SignalingOther Interleukins & Receptors
Common β Chain Receptor Family Ligands
Other Hematopoietic Stem Cell Growth Factors
Related Services
Related Products
References
- Barr, TP; Kornberg, D; et al. Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. ANALYTICAL BIOCHEMISTRY 468:28-33(2015).
- Abrishami, M; Pastushok, L; et al. Synthetic Anti-IL3 Receptor Antibodies As Therapeutics to Block Innate Imatinib Resistance in Chronic Myelogenous Leukemia. BLOOD 124:-(2014).
