INS

  • Official Full Name

    insulin

  • Overview

    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

  • Synonyms

    INS;insulin;ILPR;IRDN;IDDM1;IDDM2;MODY10;proinsulin;preproinsulin;insulin-dependent diabetes mellitus 2;OTTHUMP00000011161;OTTHUMP00000011162;OTTHUMP00000196036;OTTHUMP00000196038;OTTHUMP00000217519

Recombinant Proteins

  • Human
  • Cynomolgus
  • S.cerevisiae
  • Pig
  • Cattle
  • Mouse
  • Chicken
  • Rabbit
  • Zebrafish
  • Bovine
  • Horse
  • Guinea pig
  • Pongo pygmaeus
  • E.coli
  • HEK293
  • Human
  • Yeast
  • Mammalian Cells
  • Porcine Pancreas
  • Wheat Germ
  • Beef Pancreas
  • Bovine pancreas
  • In Vitro Cell Free System
  • S.Cerevisiae
  • Non
  • His
  • GST&His
  • GST
  • Avi&Fc&His
  • His&T7
  • His&SUMO
  • Flag
  • His&KSI
Cat.# Product name Source (Host) Species Tag Protein Length Price
INS-315H Recombinant Human Proinsulin protein E.coli Human Non 25-110 aa
INS-623C Recombinant Full Length Cynomolgus Monkey insulin Protein, His tagged HEK293 Cynomolgus His Full L. 25-110 aa
INS-14H Active Recombinant Human Insulin, Low Endotoxin, Media Grade E.coli Human Non
INS-256H Active Recombinant Human Insulin Human S.cerevisiae Non
INS-320H Active Recombinant Human INS Yeast Human Non Phe1-Lys29 & Gly1-Asn21
INS-607H Active Recombinant Human INS, Met, His&Lys-tagged E.coli Human His 25-110 a.a.
INS-88H Active Recombinant Human INS, His-tagged E.coli Human His 25-110 a.a.
INS-321 Synthesis Human Proinsulin C-Peptide (55-89), bioactive peptide hormone Human Non
INS-341H Recombinant Human INS Mammalian Cells Human His
INS-41P Porcine Insulin Porcine Pancreas Pig Non
INS-5308H Recombinant Human Insulin E.coli Human Non
INS-560C Recombinant Cattle INS protein, His & GST-tagged E.coli Cattle GST&His Phe25~Ala54
INS-561M Recombinant Mouse INS protein, His-tagged E.coli Mouse His Phe25~Ser54 and Gly90~Asn110 linked by GGGGS
INS-673C Recombinant Cattle INS Protein, His/GST-tagged E.coli Cattle GST&His Phe25~Ala54
INS-674H Recombinant Human INS Protein, His/GST-tagged E.coli Human GST&His Phe25~Asn110
INS-676P Recombinant Pig INS Protein, His/GST-tagged E.coli Pig GST&His Gly88~Asn108
INS-6775C Recombinant Chicken INS Mammalian Cells Chicken His
INS-677P Recombinant Pig INS Protein, His/GST-tagged E.coli Pig GST&His Phe25~Ala54
INS-679R Recombinant Rabbit INS Protein, His/GST-tagged E.coli Rabbit GST&His Phe25~Asn110
INS-8684Z Recombinant Zebrafish INS Mammalian Cells Zebrafish His
INS-5195HCL Recombinant Human INS 293 Cell Lysate HEK293 Human Non
CSC-TP061 Human INS Stable Cell Line-E. coli E.coli Human Non 32aa
INS-0301H Active Recombinant Human INS protein Yeast Human Non 25-53;90-110 a.a.
INS-10B Recombinant Bovine INS protein E.coli Bovine Non
INS-1135H Recombinant Horse INS protein, GST-tagged E.coli Horse GST 1-30aa
INS-1187H Recombinant Human INS Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
INS-1187H-B Recombinant Human INS Protein Pre-coupled Magnetic Beads HEK293 Human
INS-1759H Recombinant Human INS protein, His & T7-tagged E.coli Human His&T7 Phe25~Asn110
Ins-1783G Recombinant Guinea pig Ins protein, His & SUMO-tagged E.coli Guinea pig His&SUMO Phe25~Asn110
INS-18H Recombinant Human INS Protein, His-tagged E.coli Human His
INS-191HFL Active Recombinant Full Length Human INS Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
INS-193B Bovine Proinsulin Reference standard Bovine Non
INS-194H Human Proinsulin Reference standard Human Non
INS-2368H Recombinant Human INS Protein (Phe25-Thr54, Gly90-Thr110), N-His tagged E.coli Human His Phe25-Thr54, Gly90-Thr110
INS-2369H Recombinant Human INS Protein (Phe25-Asn110), N-GST tagged E.coli Human GST Phe25-Asn110
INS-2689C Recombinant Chicken INS Protein, His-tagged E.coli Chicken His Ala25-Ala54+GGGGS+Gly87-Asn107
INS-29H Recombinant Human INS protein E.coli Human Non 35
INS-321H Recombinant Human INS protein Yeast Human Non Phe25-Lys53
INS-369C Recombinant Cynomolgus Monkey INS Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus Avi&Fc&His
INS-369C-B Recombinant Cynomolgus Monkey INS Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
INS-4330R Recombinant Rabbit INS protein E.coli Rabbit Non 25-54aa
INS-5100H Recombinant Human INS Protein, GST-tagged Wheat Germ Human GST
INS-512D Native Bovine INS Beef Pancreas Bovine Non
INS-53H Active Recombinant Human INS Protein Yeast Human
INS-5435B Native Bovine Insulin Bovine pancreas Bovine Non
INS-5978HF Recombinant Full Length Human INS Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 110 amino acids
INS-60H Recombinant Human INS Protein E.coli Human
INS-61H Recombinant Human INS Protein E.coli Human
INS-623CE Recombinant Full Length Cynomolgus Monkey insulin Protein, His tagged E.coli Cynomolgus His Full L. 25-110 aa
INS-64P Recombinant Pongo pygmaeus INS1 Protein E.coli Pongo pygmaeus
INS-674B Recombinant Bovine INS protein, His-KSI-tagged E.coli Bovine His&KSI 25-54a.a.
INS-69H Human Insulin Reference standard Human Non
INS-72B Bovine Insulin Reference standard Bovine Non
INS-74P Porcine Insulin Reference standard Pig Non
INS-856H Recombinant Human INS Protein, His-tagged E.coli Human His
INS-P040H Recombinant Human INS therapeutic protein E.coli Human Non 30 aa
Insulin-P039H Recombinant Human INS therapeutic protein(Insulin human) Human Non
Insulin-P056H Recombinant Human INS therapeutic protein(Insulin lispro) E.coli Human Non 32aa
Insulin-P057H Recombinant Human INS therapeutic protein(Insulin glargine) E.coli Human Non 32aa
Insulin-P060H Recombinant Human INS therapeutic protein(Insulin aspart) S.Cerevisiae Human Non
Insulin-P061H Recombinant Human INS therapeutic protein(Insulin glulisine) E.coli Human Non

    Involved Pathway

    INS involved in several pathways and played different roles in them. We selected most pathways INS participated on our site, such as Ras signaling pathway,Rap signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Maturity onset diabetes of the young MAFA,NEUROD1,NR5A2,PAX6,HNF4G,MNX1,NKX6-1,HNF1A,PAX4,RFX6
    cGMP-PKG signaling pathway SLC25A5,VASP,ATP1A3,GNA12,CREB3L2,ATP1B3,MAPK3,ATP1A4,VDAC2,RHOA
    Prostate Cancer HSP90B1,EP300,PDGFRA,PDGFD,MAP2K1,PDGFB,PIK3R1,TCF7L2,RB1,BAD
    Type I diabetes mellitus HLA-DRA,PRF1,GZMB,HLA-DMB,HLA-DQA2,HLA-DRB4,GAD2,FASLG,HLA-DPA1,HLA-DQA1
    HIF- signaling pathway IFNGR1,PRKCB,TIMP1,ALDOA,BCL2,NOS2,PFKL,TCEB2,TF,PIK3R5
    Phospholipase D signaling pathway GAB2,PLA2G4D,KITLG,PPAP2C,DNM3,INS2,RHEB,CXCR2,PIP5K1A,PDGFC
    Non-alcoholic fatty liver disease (NAFLD) GSK3B,IRS2,SREBF1,INS1,NDUFS4,NDUFA6,RAC1,MAPK8,SDHA,NDUFS7
    Regulation of autophagy IFNA1,IFNG1-2,IFNA5,IFNPHI3,ATG7,ATG5,IFNA13,ATG10,PRKAA2,ATG4D
    Progesterone-mediated oocyte maturation GNAI2,PIK3R3B,GNAI2A,MAPK9,PIK3R1,AKT1,CDH1-A,RAF1B,IGF1RA,MAPK14B

    Protein Function

    INS has several biochemical functions, for example, hormone activity,identical protein binding,insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INS itself. We selected most functions INS had, and list some proteins which have the same functions with INS. You can find most of the proteins on our site.

    Function Related Protein
    protease binding Serpina1b,SERPINA1E,Serpina1c,SEMG2,ITGA3,TNF,KIT,COMP,FLOT2,SERPINC1
    insulin receptor binding SLC2A2,IRS2,SNX2,IGF1,IGF1R,FRS2B,DOK6,DOK4,IRS1,SNX1
    identical protein binding MSANTD3,CCDC91,SERPINB1A,LCK,RNF4,CLDN6,GPSM2,REG3B,FHOD1,CLPP
    insulin-like growth factor receptor binding SOCS1,PIK3R1,Ren1,IGF1,REN,YWHAH,IRS1,YWHAG,INSR,IGF2
    hormone activity GPHB5,EPO,GNRH2,GAST,INSL4,INHBB,URP2,HAMP,FSHB,GPHA2
    protein binding IKBKE,RNF5,RNF24,ADRBK1,STK11,CYCS,MB21D2,PSMD10,TREML1,LDOC1

    Interacting Protein

    INS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INS here. Most of them are supplied by our site. Hope this information will be useful for your research of INS.

    DCN;MAPK6

    Resources

    Gene Families

    Growth Factors

    References

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