SOST
-
Official Full Name
sclerostin -
Overview
Canonical Wnt-signalling plays an important role in the regulation of bone homeostasis by promoting the development of osteoblasts. Negative regulators of the Wnt pathway are important new therapeutic targets for the treatment of diseases with enhanced bone resorption. One of these molecules is Sclerostin, a 22.5 kD secreted glycoprotein, which acts by binding to the Wnt-coreceptor LRP5 thus preventing the binding of Wnt molecules. Sclerostin is nearly exclusively produced in osteocytes. Therefore it is considered a clinical marker which provides highest bone specificity. -
Synonyms
SOST;sclerostin;CDD;VBCH;sclerosteosis;Blosozumab;1132758-87-2;Romosozumab;909395-70-6
Recombinant Proteins
- Human
- Rat
- Mouse
- Cynomolgus
- Rhesus macaque
- HEK293
- E.coli
- Mammalian cells
- C-His
- Mammalian Cell
- Human Cell
- HEK293F
- Insect Cell
- Mammalian cell
- His
- His&GST
- Non
- His&Myc
- His&Fc&Avi
- Fc
- His&Avi
- His&SUMO
Involved Pathway
SOST involved in several pathways and played different roles in them. We selected most pathways SOST participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | PORCNL,WNT7AA,PPP3CA,FZD9,LRP5,PPARDB,ROCK2A,SIAH1,PLCB4,RHOAD |
Protein Function
SOST has several biochemical functions, for example, heparin binding,protein binding,transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOST itself. We selected most functions SOST had, and list some proteins which have the same functions with SOST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | ADAMTS8,PCSK6,SLIT3,BMP4,TENM1,SLIT2,NDNF,WISP1B,NAV2,ANG |
| transcription factor binding | MYOD1,DRAP1,LCOR,PPARGC1A,PURB,KAT6B,HDAC3,PER1,ESR1,MYC |
| protein binding | GPSM2,NRADD,RILP,MTA2,CD2,EOMESA,MVP,TMEM203,KEAP1,C9orf16 |
Interacting Protein
SOST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOST here. Most of them are supplied by our site. Hope this information will be useful for your research of SOST.
LRP4;LRP5;LRP6;Ca1;Jph1;Tnik;bt3l4_rat_protein
Resources
Related Services
Related Products
References
- Recker, RR; Benson, CT; et al. A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density. JOURNAL OF BONE AND MINERAL RESEARCH 30:216-224(2015).
- Gerbaix, M; Vico, L; et al. Periostin expression contributes to cortical bone loss during unloading. BONE 71:94-100(2015).
