SNCA
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Official Full Name
synuclein, alpha (non A4 component of amyloid precursor) -
Overview
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009] -
Synonyms
SNCA;synuclein, alpha (non A4 component of amyloid precursor);PD1;NACP;PARK1;PARK4;alpha-synuclein;synuclein alpha-140;non A-beta component of AD amyloid
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rat
- Pongo Abelii
- Ateles geoffroyi
- Monkey
- Erythrocebus patas (Red guenon) (Cercopithecus patas)
- Pan paniscus
- Saguinus labiatus (Red-chested mustached tamarin)
- Chicken
- Pig
- E.coli
- Human
- HEK293
- Mammalian Cell
- E.Coli or Yeast
- E. coli
- Mammalian cells
- Yeast
- HEK293T
- Synthetic
- GST
- Non
- His
- Fc
- His&SUMO
- His&Fc&Avi
- Myc&DDK
- His&Avi
- Flag
- His&Myc
Involved Pathway
SNCA involved in several pathways and played different roles in them. We selected most pathways SNCA participated on our site, such as Alzheimers disease,Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | TH,NDUFA5,Casp3,UQCRQ,GNAI1,UQCRC1,COX8C,PARK2,ATP5D,NDUFA10 |
| Alzheimers disease | ATP2A3,NDUFS2,ADAM17,NDUFC2,NDUFB9,SDHC,NDUFB8,CAPN2,ITPR3,NDUFB2 |
Protein Function
SNCA has several biochemical functions, for example, alpha-tubulin binding,beta-tubulin binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCA itself. We selected most functions SNCA had, and list some proteins which have the same functions with SNCA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinesin binding | CD36,MAPK8IP3,MAPK8IP2,DISC1,PRC1,PLEKHM2,SERPINB1A,IFT88,KLC2,NEFH |
| phospholipase binding | PRKCZ,CALM1,WAS,PDPK1,PARK2,CALM,CALM2,ARHGAP6,PTPN11,Pla2r1 |
| beta-tubulin binding | PIFO,CCT5,HTT,MAP1S,EMD,TBCD,BBS4,B4GALT1,PROL1,HDAC6 |
| ferrous iron binding | ALKBH2,PLOD1,FXN,UROD,TET2,ALKBH3,FTO,ACP5,FECH,CDO1 |
| calcium ion binding | ANXA9,TLL2,APCS,GUCA1B,PCDH1G9,DMP1,NOTCH1,TC2N,FSTL4,FSTL5 |
| phospholipid binding | ESYT1,FABP1,PLEKHA3,WDFY4,AGAP1,NOXO1,APOA5,SYTL4,RASAL1,ARHGAP44 |
| protein domain specific binding | TH,PICK1,SCN5A,TJP2,STX18,STAMBP,CTBP1,HIST4H4,KCTD13,TFDP2 |
| dynein binding | SERPINB1A,ATMIN,PAFAH1B1A,NEFH,BICD1,PAFAH1B1B,DCTN1,SMC3,WDR43,LRRC50 |
| microtubule binding | ARHGEF2,CLASP1,RAE1,MAPRE2,NUMA1,EML2,CETN1,KATNA1,KATNAL1,KIF15 |
Interacting Protein
SNCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCA here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCA.
Resources
Research Area
ALS Related MoleculesParkinson's Disease Related Molecules
Synaptic Proteins
Synaptic SNAREs
Neuronal Lineage Markers
Related Services
Related Products
References
- Alvarez-Castelao, B; Gorostidi, A; et al. Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls. FRONTIERS IN AGING NEUROSCIENCE 6:-(2014).
- Daher, JPL; Volpicelli-Daley, LA; et al. Abrogation of alpha-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:9289-9294(2014).
