Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), Delta-NAC

• Cat.No.: SNCA-291H
• Product Overview: Recombinant Human α-SynucleinDelta-NAC protein produced in E.Coli encodes 111 amino acids and has a molecular mass of 11.9 kDa.

Specification

• Cat. No.: SNCA-291H
• Description: A deletion mutant of α-synuclein that lacks the NAC region (amino acid 61-95). α-synuclein(ΔNAC) was overexpressed in E. coli and purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques. 6 amino acids were added as a linker.
• Source: E.coli.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl.
• Molecular Weight: 11.9 kDa (111 aa) (Real molecular size on SDS-PAGE will be shift up).
• Purity: >95% by SDS PAGE.
• Concentration: 1mg/ml (determined by BCA assay).
• Sequence: MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK GTEIWMKKDQ LGKNEEGAPQ EGILEDMPVD PDNEAYEMPS EEGYQDYEPE A
• Storage: Store at -20 °C. Avoid freeze/thaw cycles.
• Tag: Non

Gene Information

• Gene Name: SNCA
• Synonyms: SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; MGC110988; alpha-synuclein, isoform NACP140; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161561; non A-beta component of AD amyloid; synuclein, alpha (non A4 component of amyloid precursor); Synuclein, alpha (non-Abeta component of Alzheimer"s disease amyloid precursor protein: NACP).
• Gene ID: 6622
• mRNA Refseq: NM_000345.3
• Protein Refseq: NP_000336.1
• MIM: 163890
• UniProt ID: P37840
• Chromosome Location: 4q21
• Pathway: Alzheimer"s disease; Neurodegenerative Disorders;Parkinson"s disease.
• Function: Hsp70 protein binding; alpha-tubulin binding;dynein binding; histone binding; kinesin binding; tau protein binding; transferrin transmembrane transporter activity.