LIF
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Official Full Name
leukemia inhibitory factor -
Overview
LIF (Leukocyte inhibitory factor) is produced by various fibroblast cell lines, antigen-stimulated alloreactive T-lymphocytes, mitogen-activated spleen cells, and Krebs and Ehrlich ascites cells. It is also produced by monocytes after cell activation. This factor inhibits the random and directed migration of polymorphonuclear (PMN) leukocytes. LIF also induces specific granule secretion by PMNs and potentiates many responses mediated by the chemotactic compound fMLP (formyl-methionyl-leucyl-phenylalanine). It activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes. -
Synonyms
LIF;leukemia inhibitory factor;CDF;cholinergic differentiation factor;DIA;differentiation inhibitory activity;differentiation inducing factor;hepatocyte stimulating factor III;HILDA;human interleukin in DA cells;D factor;melanoma-derived LPL inhibitor;differentiation-inducing factor;hepatocyte-stimulating factor III;differentiation-stimulating factor;MLPLI
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Dog
- Cattle
- E.coli
- HEK293
- Yeast
- Hordeum Vulgare
- Insect Cells
- Barley Grain
- Human Cells
- CHO
- Mammalian Cells
- Non
- His
- Avi&His
- GST
- Fc
- Strep II
- GST&His
- His&T7
- Avi&Fc&His
- DDK&Myc
- Flag
- His&SUMO&Trx
Involved Pathway
LIF involved in several pathways and played different roles in them. We selected most pathways LIF participated on our site, such as Cytokine-cytokine receptor interaction,Signaling pathways regulating pluripotency of stem cells,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | SOS1,IFNPHI3,IFNA16,GFAP,FHL1B,AOX1,PIAS2,SOCS1A,IFNG1-2,AOX3L1 |
| TNF signaling pathway | MAP2K6,CREB5,MAP2K7,MMP9,CXCL2,CREB3L2,FOS,MAPK3,TRAF2,DNM1L |
| Signaling pathways regulating pluripotency of stem cells | ACVR1,NRAS,NODAL,WNT11,HNF1A,PCGF2,SMAD1,SMARCAD1,INHBB,WNT2B |
| Cytokine-cytokine receptor interaction | IL17RB,IL6ST,CXCL12,CXCL12A,TNFSF14,TNFRSF19,CCR8L,CXCR6,TNFRSF1B,EDAR |
Protein Function
LIF has several biochemical functions, for example, cytokine activity,growth factor activity,leukemia inhibitory factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIF itself. We selected most functions LIF had, and list some proteins which have the same functions with LIF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| leukemia inhibitory factor receptor binding | Ctf2,CTF1 |
| growth factor activity | NRG4,TFF1,HDGF,OSM,DKK1,MDK,PDGFA,NUDT6,NDR2,FGF9 |
| transcription factor activity, RNA polymerase II transcription factor recruiting | NCOA3 |
| cytokine activity | IFNW1,GPI,GDF7,GM13285,IL1B,NDR2,BMP6,TNFB,CCL38A.5,IL16 |
| receptor binding | CADM1A,CAT,UTS2,RND1,HAMP,SLC9A3R2,CADM1,NRG2A,FGF1A,NTF7 |
Interacting Protein
LIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIF here. Most of them are supplied by our site. Hope this information will be useful for your research of LIF.
IL6ST;LIFR
Resources
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References
- Levy, YA; Mausner-Fainberg, K; et al. Dysregulated production of leukemia inhibitory factor in immune cells of relapsing remitting multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY 278:85-89(2015).
- Leung, SJ; Rice, PS; et al. In Vivo Molecular Mapping of the Tumor Microenvironment in an Azoxymethane-Treated Mouse Model of Colon Carcinogenesis. LASERS IN SURGERY AND MEDICINE 47:40-49(2015).
