FLT3LG
-
Official Full Name
Fms-related tyrosine kinase 3 ligand -
Overview
Flt-3 ligand (FL) is a recently identified hematopoietic cytokine whose activities are mediated by binding to the transmembrane glycoprotein Flt-3. Flt-3 was first discovered as a member of the class III subfamily of receptor tyrosine kinases (RTK) whose expression among hematopoietic cells was found to be restricted to highly enriched stem/progenitor cell populations. Additional class III RTKs include the receptors from SCF, M-CSF and PDGF. Not surprisingly, Flt-3 ligand is also structurally related to M-CSF and SCF. All three cytokines have been shown to exist both as type I transmembrane proteins and as soluble proteins. The predominant human FL isoform is a transmembrane protein that can undergo proteolytic cleavage to generate a soluble form of the protein. An alternatively-spliced FL mRNA, encoding a soluble form of the human FL, has also been identified. FL is widely expressed in various human and mouse tissues. At the amino acid sequence level, human and mouse FL are approximately 72% identical and the two proteins exhibit cross-species activity. FL has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors. -
Synonyms
Flt 3 ligand;Flt 3L;Flt3 L;FLT3 LG;Flt3 ligand;Flt3L;FLT3L_HUMAN;Flt3lg;Fms related tyrosine kinase 3 ligand;Fms-related tyrosine kinase 3 ligand;SL cytokine;Flt3lg
Recombinant Proteins
- Human
- Feline
- Porcine
- Mouse
- Rhesus macaque
- Pig
- Rat
- Mus musculus
- CHO
- E.coli
- Mammalian cells
- Sf21 Insect Cell
- Sf9 Insect Cell
- Insect Cell
- Nicotiana Benthamiana
- Baculovirus
- C-His
- N/A
- Insect cell (High Five)
- Human Cell
- HEK293
- Hordeum Vulgare
- Insect Cells
- Baculovirus-Insect cells
- Human cells
- HEK293T
- Human Cells
- Barley Grain
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- Fc
- Non
- His
- Flag
- StrepII
- GST
- His&Fc
- His&GST
- Myc&DDK
- His&SUMO
- His&Fc&Avi
- His&mFc
Involved Pathway
FLT3LG involved in several pathways and played different roles in them. We selected most pathways FLT3LG participated on our site, such as Cytokine-cytokine receptor interaction,Hematopoietic cell lineage,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT3LG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | GP1BB,IL9R,CD3E,CD3G,IL1R2,CD59,IL11RA2,IL6,Il6ra,IL5 |
| Pathways in cancer | RAF1,PTGER2,RASGRP3,AXIN2,GLI1,PIAS2,PTGER1,NKX3-1,Kitl,TRAF6 |
| Cytokine-cytokine receptor interaction | IL-8,CXCL8,IL20RB,PDGFRB,CCL20A.3,IL10RA,TNFRSF6B,KITA,IFNA10,Ccl9 |
Protein Function
FLT3LG has several biochemical functions, for example, cytokine activity,protein homodimerization activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT3LG itself. We selected most functions FLT3LG had, and list some proteins which have the same functions with FLT3LG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | Ctf2,GDF15,NAMPT,WNT7A,INHBB,TNFSF13B,CLCF1,MSTNB,TGFB3,Gm13290 |
| protein homodimerization activity | ASMT,TMEM192,CALCOCO2,BAK1,TBX18,PTPRO,SLC26A5,PSMD7,DAXX,ERBB3 |
| receptor binding | WNT4A,ICAM3,NPFF,TENM2,SMAGP,HSPA1B,LAMA3,FGF20B,SCYL2,PECI |
| receptor tyrosine kinase binding | ANGPT1,TP53,SHC3,ANXA5,TOB1,LRP4,PITPNM3,NRG1,NCK1,ARHGEF16 |
Interacting Protein
FLT3LG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT3LG here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT3LG.
KITLG;PFN2
Resources
Related Services
Related Products
References
