ACE2

  • Official Full Name

    angiotensin I converting enzyme 2

  • Overview

    The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

  • Synonyms

    ACE2;angiotensin I converting enzyme 2;ACEH;angiotensin-converting enzyme 2;peptidyl-dipeptidase A;metalloprotease MPROT15;ACE-related carboxypeptidase;angiotensin-converting enzyme homolog;angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Rhesus macaque
  • Cynomolgus
  • Paguma larvata
  • Dog
  • Zebrafish
  • SARS-CoV-2
  • Mink
  • Golden hamster
  • HEK293
  • Human Cells
  • Mammalian Cells
  • E.coli
  • CHO
  • Insect Cells
  • Nicotiana Benthamiana
  • His
  • Fc
  • Fc&His
  • mFc
  • Avi&His
  • Flag
  • Avi&Fc
  • Avi&mFc
  • His&T7
  • Non
  • Avi&Fc&His
  • Flag&His
  • GST
  • His&Strep II
Cat.# Product name Source (Host) Species Tag Protein Length Price
ACE2-736H Recombinant Human ACE2 protein, His-tagged HEK293 Human His Gln18-Ser740
ACE2-68H Active Recombinant Human ACE2, Fc-tagged HEK293 Human Fc Met 1-Ser 740
ACE2-736HA Active Recombinant Human ACE2, His-tagged, APC labeled HEK293 Human His
Ace2-1183M Recombinant Mouse Ace2 protein, His&hFc-tagged HEK293 Mouse Fc&His Met1-Thr740
ACE2-185H Active Recombinant Human ACE2 protein, mFc-tagged HEK293 Human mFc Gln 18 - Ser 740
Ace2-1184M Recombinant Mouse ACE2 protein(Met1-Thr740), His-tagged HEK293 Mouse His 1-740 a.a.
Ace2-1194R Active Recombinant Rat Ace2 protein(Met1-Thr740), His-tagged HEK293 Rat His Met1-Thr740
ACE2-239H Recombinant Human ACE2, Fc tagged Human Cells Human Fc 1-740 a.a.
ACE2-2186H Active Recombinant Human ACE2 protein, mFc-tagged HEK293 Human mFc Met1-Ser740
ACE2-229H Recombinant Human ACE2 protein, His/Avi-tagged Mammalian Cells Human Avi&His 723
ACE2-2452H Recombinant Human ACE2 protein, His-tagged E.coli Human His 392-744 aa
ACE2-40H Recombinant Human ACE2 Protein, His-tagged E.coli Human His Gln18-Ser740
ACTN4-2451H Recombinant Human ACTN4 protein, His-tagged E.coli Human His 612-911 aa
ACE2-206R Active Recombinant Rhesus monkey ACE2 protein, His-tagged HEK293 Rhesus macaque His Met1-Val739
Ace2-639R Active Recombinant Rat Ace2, His-tagged Mammalian Cells Rat His 1-740 a.a.
ACE2-69M Active Recombinant Mouse ACE2, FLAG-tagged HEK293 Mouse Flag 1-740 a.a.
ACE2-018C Active Recombinant Cynomolgus monkey ACE2 protein, hFc-tagged Mammalian Cells Cynomolgus Fc 18-741aa
ACE2-019P Active Recombinant Paguma larvata ACE2 protein, hFc-tagged Mammalian Cells Paguma larvata Fc 18-740aa
ACE2-051H Active Recombinant Human ACE2 protein, His/Avi-tagged, Biotinylated CHO Human Avi&His Gln18 - Ser740
ACE2-052H Active Recombinant Human ACE2 protein, Fc/Avi-tagged, Biotinylated CHO Human Avi&Fc Gln18-Ser740
ACE2-1082H Recombinant Human ACE2 protein(Met1-Ser740), His-tagged, Biotinylated HEK293 Human His Met1-Ser740
ACE2-207R Active Recombinant Rhesus ACE2 protein, hFc-tagged HEK293 Rhesus macaque Fc Met1-Val739
ACE2-3407H Active Recombinant Human ACE2 protein(Met1-Ser740), His-Avi-tagged, Biotinylated Insect Cells Human Avi&His Met1-Ser740
ACE2-602D Active Recombinant Dog ACE2 Protein, Fc-tagged CHO Dog Fc 18-739
Ace2-603R Active Recombinant Rat ACE2 Protein, Fc-tagged CHO Rat Fc 18-740
ACE2-817HB Active Recombinant Human ACE2 protein, mFc-Avi-tagged Mammalian Cells Human Avi&mFc 18-740aa
ACE2-107C Recombinant Cynomolgus ACE2, Fc tagged Human Cells Cynomolgus Fc 1-739 a.a.
ACE2-108C Recombinant Cynomolgus ACE2 protein, His-tagged HEK293 Cynomolgus His Gln18-Thr741
ACE2-1691Z Recombinant Zebrafish ACE2 Mammalian Cells Zebrafish His
Ace2-1930M Recombinant Mouse Ace2 protein, His & T7-tagged E.coli Mouse His&T7 Ile93~Phe464
Ace2-1931R Recombinant Rat Ace2 protein, His & T7-tagged E.coli Rat His&T7 Leu392~Val739
ACE2-67H Active Recombinant Human ACE2, FLAG-tagged HEK293 Human Flag 1-740 a.a.
ACE2-735H Recombinant Human ACE2 Protein, His-tagged HEK293 Human His
ACE2-745H Recombinant Human ACE2, His-tagged Mammalian Cells Human His 1-740 a.a.
Ace2-761M Recombinant Mouse Ace2 protein, His-tagged HEK293 Mouse His Gln 18 - Thr 740
ACE2-1851RCL Recombinant Rat ACE2 cell lysate Human Cells Rat Non
ACE2-2085MCL Recombinant Mouse ACE2 cell lysate Human Cells Mouse Non
ACE2-3100HCL Recombinant Human ACE2 cell lysate Human Cells Human Non
ACE2-887CCL Recombinant Cynomolgus ACE2 cell lysate Human Cells Cynomolgus Non
ACE2-0048H Recombinant Human ACE2 Protein HEK293 Human
ACE2-0076H Recombinant Human ACE2 Protein (Gln18-Ser740), C-His-tagged Mammalian Cells Human His Gln18-Ser740
ACE2-0077H Recombinant Human ACE2 Protein (Leu391-Ser740), N-His-tagged E.coli Human His Leu391-Ser740
ACE2-0078H Recombinant Human ACE2 Protein (Leu392-Ser740), His-tagged E.coli Human His Leu392-Ser740
ACE2-007M Human ACE2-coupled magnetic beads SARS-CoV-2
ACE2-009H Active Recombinant Human ACE2 protein, Fc-tagged Human Cells Human Fc
ACE2-01H Recombinant Human ACE2 protein, His-Avi-tagged HEK293 Human Avi&His Gln18-Ser740
ACE2-026H Active Recombinant Human ACE2 Protein, hIgG/His-tagged HEK293 Human Fc&His
ACE2-02H Recombinant Human ACE2 Protein (ECD), Fc-tagged(C-ter) HEK293 Human Fc Gln18-Ser740
ACE2-031H Recombinant Human ACE2 Protein, Fc-tagged CHO Human Fc 18-615
ACE2-032D Recombinant Dog ACE2 Protein, Fc-tagged CHO Dog Fc 18-739
Ace2-033R Recombinant Rat ACE2 Protein, Fc-tagged CHO Rat Fc 18-740
ACE2-034H Recombinant Human ACE2 Protein, Fc-tagged CHO Human Fc 19-740
ACE2-03H Recombinant Human ACE2 Protein (ECD), His-tagged(N-ter) HEK293 Human His Gln18-Ser740
ACE2-0464H Recombinant Human ACE2 Protein (M1-S740), Tag Free Insect Cells Human Non M1-S740
ACE2-0465H Recombinant Human ACE2 protein(Met1-Ser740), His-tagged Insect Cells Human His Met1-Ser740
ACE2-04H Recombinant Human ACE2 Protein, Human IgG1 Fc-tagged(C-ter) CHO Human Fc
ACE2-089H Recombinant Human ACE2 Protein, DYKDDDDK-tagged Human Cells Human Flag
ACE2-090H Recombinant Human ACE2 Protein, Fc-tagged Human Cells Human Fc 18-615 a.a.
ACE2-091H Recombinant Human ACE2 Protein, Fc-tagged Human Cells Human Fc 18-708 a.a.
ACE2-092H Recombinant Human ACE2 protein, hFc-tagged HEK293 Human Fc Gln18-Ser740
Ace2-09R Active Recombinant Rat Ace2 Protein, His-tagged Insect Cells Rat His 18-740 a.a.
Ace2-105R Recombinant Rat Ace2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
Ace2-105R-B Recombinant Rat Ace2 Protein Pre-coupled Magnetic Beads HEK293 Rat
ACE2-1071HFL Recombinant Human ACE2 protein, His&Flag-tagged HEK293 Human Flag&His 1-805 aa
ACE2-109C Recombinant Cynomolgus ACE2 protein, His-Avi-tagged HEK293 Cynomolgus Avi&His Gln18-Val739
ACE2-109CB Recombinant Cynomolgus ACE2 protein, His-Avi-tagged, Biotinylated HEK293 Cynomolgus Avi&His Gln18-Val739
ACE2-10H Active Recombinant Human ACE2 Protein, FLAG-tagged, Biotinylated HEK293 Human Flag 18-740
ACE2-1368H Recombinant Human ACE2 protein(Met1-Ser740), hFc-tagged, Biotinylated HEK293 Human Fc Met1-Ser740
ACE2-13H Recombinant Human ACE2 Protein, His-tagged Nicotiana Benthamiana Human His 19-615
ACE2-2012M Active ACE2 protein-coupled magnetic Beads HEK293 Human Gln 18 - Ser 740
ACE2-208H Active Recombinant Human ACE2 Protein, His\Avi-tagged Human Cells Human Avi&His 18-740 a.a.
ACE2-2165H Active Recombinant Human ACE2 protein, His-tagged HEK293 Human His Met1-Ser740
ACE2-230H Recombinant Human ACE2 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Gln18-Ser740
ACE2-231H Recombinant Human ACE2 protein, hFc-Avi-tagged, Biotinylated HEK293 Human Avi&Fc Gln18-Ser740
ACE2-23H Recombinant Human ACE2 Protein (ECD, AA 20-707), C-Avi/His-Tagged, Biotinylated HEK293 Human Avi&His AA 20-707
ACE2-2413H Recombinant Human ACE2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ACE2-2413H-B Recombinant Human ACE2 Protein Pre-coupled Magnetic Beads HEK293 Human
ACE2-24H Recombinant Human ACE2 Protein (ECD, AA 20-707), C-Avi/His-Tagged, non-biotinylated HEK293 Human Avi&His AA 20-707
ACE2-25H Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free HEK293 Human Non AA 20-708
ACE2-264H Recombinant Human ACE2 Protein (Gln18-Ser740), C-Fc tagged, Animal-free, Carrier-free HEK293 Human Fc Gln18-Ser740
ACE2-26H Recombinant Human ACE2 Protein (ECD, processed, AA 20-708), Tag-free HEK293 Human Non AA 20-708
ACE2-2879M Active Recombinant Mink ACE2 protein, His-tagged HEK293 Mink His Gln 18-Thr 740
ACE2-2880H Active Recombinant Human ACE2 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Gln 18-Ser 611
ACE2-2881H Recombinant Human ACE2 protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His Gln18-Ser740
ACE2-2882P Active Recombinant Paguma larvata ACE2 protein, His-tagged HEK293 Paguma larvata His Gln 18-Thr 740
ACE2-301568H Recombinant Human ACE2 protein, GST-tagged E.coli Human GST Asp30-Phe356
ACE2-32H Recombinant Human ACE2 Protein, His-tagged E.coli Human His Leu392-Ser740
ACE2-33H Recombinant Human ACE2 Protein, His-tagged HEK293 Human His Gln18-Ser740
Ace2-34M Recombinant Mouse Ace2 Protein, His-tagged E.coli Mouse His Ile93-Phe464
ACE2-35M Recombinant Mouse ACE2 Protein, His-tagged Human Cells Mouse His 18-740 a.a.
Ace2-35R Recombinant Rat Ace2 Protein, His-tagged E.coli Rat His Leu392-Val739
ACE2-369H Recombinant Human ACE2 Protein (Gln18-Ser740), C-hFc-tagged HEK293 Human Fc Gln18-Ser740
ACE2-36H Recombinant Human ACE2 Protein, His-tagged HEK293 Human His Gln18-Ser740
ACE2-36R Recombinant Rhesus Macaque ACE2 Protein, His-tagged Human Cells Rhesus macaque His 18-739 a.a.
ACE2-370H Recombinant Human ACE2 Protein (Gln18-Ser740), C-mFc-tagged HEK293 Human mFc Gln18-Ser740
Ace2-37M Recombinant Mouse Ace2 Protein, His-tagged HEK293 Mouse His Gln18-Thr740
ACE2-37R Recombinant Rhesus Macaque ACE2 Protein, Fc-tagged Human Cells Rhesus macaque Fc 18-739 a.a.
ACE2-38H Recombinant Human ACE2 Protein, hFc-tagged HEK293 Human Fc 18-740 a.a.
Ace2-38R Recombinant Rat Ace2 Protein, His-tagged HEK293 Rat His Met1-Thr740
ACE2-39H Recombinant Human ACE2 Protein, His-tagged E.coli Human His Leu392-Ser740
ACE2-5058H Recombinant Human ACE2 Protein (Ser19-Asp615), C-His tagged Mammalian Cells Human His Ser19-Asp615
ACE2-5059H Recombinant Human ACE2 Protein (Ser19-Asp615), C-Fc tagged Mammalian Cells Human Fc Ser19-Asp615
ACE2-5060H Recombinant Human ACE2 Protein (Ser19-Ser740), C-His tagged Mammalian Cells Human His Ser19-Ser740
ACE2-5061H Recombinant Human ACE2 Protein (Ser19-Ser740) Mammalian Cells Human Non Ser19-Ser740
ACE2-5062H Recombinant Human ACE2 Protein (Ser19-Ser740), HRP Labeled Mammalian Cells Human Non Ser19-Ser740
ACE2-601H Active Recombinant Human ACE2 Protein, Fc-tagged CHO Human Fc 18-615
ACE2-604H Active Recombinant Human ACE2 Protein, Fc-tagged CHO Human Fc 18-615
Ace2-6325G Recombinant Golden hamster Ace2 protein, His&Strep II-tagged E.coli Golden hamster His&Strep II 20-604a.a.
ANG-013 Recombinant ACE2 Protein, His-tagged
ANG-014 Recombinant ACE2 Protein, hFc-tagged
HUM-290 Recombinant Human ACE2 Protein, Fc-tagged CHO
HUM-291 Recombinant Human ACE2 Protein, sFc-tagged HEK293
HUM-292 Recombinant Human ACE2 Protein, Fc-tagged CHO
Kit-2101 Angiotensin II Converting Enzyme Inhibitor Screening Kit Non
Kit-2210 Angiotensin II Converting Enzyme (ACE2) Activity Assay Kit (Fluorometric) Non

    Involved Pathway

    ACE2 involved in several pathways and played different roles in them. We selected most pathways ACE2 participated on our site, such as Renin-angiotensin system,Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein digestion and absorption COL7A1,COL18A1,CPA2,MEP1A,SLC7A8,ATP1A2,KCNE3,PRSS1,SLC15A1,CPA3
    Renin-angiotensin system AGTR1B,KLK1B26,CMA1,ANPEP,KLK1B1,MAS1,KLK1B24,ATP6AP2,CTSA,PRCP

    Protein Function

    ACE2 has several biochemical functions, for example, carboxypeptidase activity,endopeptidase activity,glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACE2 itself. We selected most functions ACE2 had, and list some proteins which have the same functions with ACE2. You can find most of the proteins on our site.

    Function Related Protein
    virus receptor activity SLC10A1,CLEC4G,SLC20A2,PVRL4,XPR1,SCARB1,TNFRSF4,HAVCR1,SIVA1,CD80
    glycoprotein binding SERPINA1,VLDLR,HFE2,LMAN2,FGFR1,PLAT,BBC3,LGALS1,RGMA,ITGA3
    zinc ion binding RNF214,CA6,TRIM35-29,UBOX5,PAPLN,MMP25,GTF2B,USP3,RNF146,ZKSCAN5
    endopeptidase activity ACE,MME,PSMA4,ADAM10,TMEM59,SENP3,KLK1B26,FURIN,PSMB7,P4HB
    protein binding MAL,RNF113A,CDKN2D,C3orf52,CAMKK1,ADRM1,UCHL1,SPOP,GPR85,PLK1S1
    carboxypeptidase activity CPD,CPA2,CPE,CPM,BLMH,CTSA,CNDP2,AGBL4,PGCP,CNDP1

    Interacting Protein

    ACE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACE2.

    CALM1

    Resources

    Research Area

    Renal Markers
    Metalloproteases and Regulators

    References

    • Sui, JH; Deming, M; et al. Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness. JOURNAL OF VIROLOGY 88:13769-13780(2014).
    • Prasad, T; Verma, A; et al. Expression and cellular localization of the Mas receptor in the adult and developing mouse retina. MOLECULAR VISION 20:1443-1455(2014).

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