Recombinant Human ACE2 Protein, hFc-tagged

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 18-740 a.a.
• Description: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensin I and II as a carboxypeptidase and converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor do not inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
• Form: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
• Molecular Mass: Predicted Molecular Weight: 109kDa
  Apparent Molecular Weight: 116kDa, reducing conditions.
• AA Sequence: 18-740 aa
• Endotoxin: Less than 0.1 EU/ug.
• Purity: >95%
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
  Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
• Reconstitution: It is not recommended to reconstitute to a concentration less than 100μg/ml.
  Dissolve the lyophilized protein in distilled water.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles
• Quality Statement: Purity: >95% as determined by reducing SDS-PAGE.
• Shipping: Ambient

Gene Information

• Gene Name: ACE2 angiotensin converting enzyme 2 [ Homo sapiens (human) ]
• Official Symbol: ACE2
• Synonyms: Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE-2
• Gene ID: 59272
• mRNA Refseq: NM_021804.3
• Protein Refseq: NP_068576.1
• MIM: 300335
• UniProt ID: Q9BYF1