Active Recombinant Human ACE2 Protein, His\Avi-tagged

• Cat.No.: ACE2-208H
• Product Overview: Biotinylated Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Avi, 6His tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: Avi&His
• Protein Length: 18-740 a.a.
• Description: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
• Form: Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
• Bio-activity: Immobilized 2019-nCoV S Protein RBD-SD1-mFc at 2μg/ml (100μl/well) can bind Human ACE-2-Avi-His.The ED50 of Human ACE-2-Avi-His is 46.47 ng/ml.
• Molecular Mass: Predicted Molecular Weight: 86.2kDa
  Apparent Molecular Weight: 110-140kDa, reducing conditions.
• AA Sequence: Gln18-Ser740
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Purity: >95%
• Storage: Store at < -20 centigrade, stable for 6 months after receipt.
  Please minimize freeze-thaw cycles.
• Quality Statement: Purity: greater than 95% as determined by reducing SDS-PAGE.
• Shipping: The product is shipped on dry ice pack.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: ACE2 angiotensin converting enzyme 2 [ Homo sapiens (human) ]
• Official Symbol: ACE2
• Synonyms: Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE-2
• Gene ID: 59272
• mRNA Refseq: NM_021804.3
• Protein Refseq: NP_068576.1
• MIM: 300335
• UniProt ID: Q9BYF1