Recombinant Human ACE2, His-tagged

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 1-740 a.a.
• Description: ACE-2 cleaves angiotensins I and II as a carboxypeptidase and plays an important role in regulating cardiovascular and renal functions. Native ACE-2 is an integral membrane zinc metalloprotease whose activity is inhibited by EDTA.
• Purity: ≥90% by SDS-PAGE.
• Form: Liquid. Please refer to vial label for lot-specific concentration.
• Endotoxins: ≤1.0 EU/µg ACE-2.
• Specific Activity: ≥0.8 unit/µg protein.
• Unit Definition: One unit is defined as the amount of enzyme that will cleave 1 nmol MCA-YVADAPK(DNP)-OH per min at 25℃, pH 7.5.
• Toxicity: Standard Handling (MSDS available upon request).
• Storage: ≤ -70℃. Avoid freeze/thaw. Following initial thaw, aliquot and freeze (-70℃).

Gene Information

• Gene Name: ACE2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 [ Homo sapiens ]
• Synonyms: ACE2; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; ACEH; DKFZp434A014; angiotensin I converting enzyme; ACE-related carboxypeptidase2; angiotensin converting enzyme-like protein; EC 3.4.15.1; EC 3.4.17.-; Angiotensin-converting enzyme 2; ACEH
• Gene ID: 59272
• mRNA Refseq: NM_021804
• Protein Refseq: NP_068576
• MIM: 300335
• UniProt ID: Q9BYF1
• Chromosome Location: Xp22
• Pathway: Renin-angiotensin system
• Function: carboxypeptidase activity; chloride ion binding; glycoprotein binding; metal ion binding; metallopeptidase activity; peptidase activity; peptidyl-dipeptidase activity; viral receptor activity; zinc ion binding