Active Recombinant Human ACE2 protein, Fc-tagged

• Cat.No.: ACE2-009H
• Product Overview: Recombinant Human ACE2 protein with a Fc tag was expressed in human cells.

Specification

• Species: Human
• Source: Human Cells
• Tag: Fc
• Description: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the causative agent of coronavirus disease-2019 (COVID-19).
• Form: Liquid
• Bio-activity: ACE-2, Human can bind with S-RBD in functional ELISA assay.
• Molecular Mass: 110.5KD
• Purity: > 95% as analyzed by SDS-PAGE
• Storage: The product can be stored at -20 centigrade or below. Avoid repeated freezing and thawing cycles. The shelf life of the product is unspecified.
• Storage Buffer: 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4

Gene Information

• Gene Name: ACE2 angiotensin I converting enzyme 2 [ Homo sapiens (human) ]
• Official Symbol: ACE2
• Synonyms: ACE2; angiotensin I converting enzyme 2; ACEH; angiotensin-converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; truncated angiotensin converting enzyme 2; EC 3.4.17.23
• Gene ID: 59272
• mRNA Refseq: NM_021804
• Protein Refseq: NP_068576
• MIM: 300335
• UniProt ID: Q9BYF1