Active Recombinant Human IL11 Protein

• Cat.No.: IL11-061H
• Product Overview: The mature recombinant human IL-11 protein consists of 179 amino acids (19-178) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 19-178 a.a.
• Description: The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Bio-activity: Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. The ED50 for this effect is 0.02-0.12 ng/mL.
• Molecular Mass: 19.3 kDa
• Product-Related Proteins: 19-178
• Endotoxin: < 1.0 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: IL11 interleukin 11 [ Homo sapiens (human) ]
• Official Symbol: IL11
• Synonyms: IL11; interleukin 11; AGIF; IL-11; interleukin-11; adipogenesis inhibitory factor; oprelvekin
• Gene ID: 3589
• mRNA Refseq: NM_000641
• Protein Refseq: NP_000632
• MIM: 147681
• UniProt ID: P20809