Cd27

  • Official Full Name

    CD27 molecule

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

  • Synonyms

    CD27;CD27 molecule;T14;S152;Tp55;TNFRSF7;S152. LPFS2;CD27 antigen;CD27L receptor;T cell activation antigen S152;T-cell activation antigen CD27;tumor necrosis factor receptor superfamily, member 7

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mouse
  • Monkey
  • Cynomolgus/Rhesus macaque
  • Rat
  • Cynomolgus
  • Golden hamster
  • Mus musculus
  • HEK293
  • Human Cells
  • Insect Cells
  • CHO
  • Mammalian Cells
  • C-His
  • Wheat Germ
  • E.coli
  • Rabbit
  • In Vitro Cell Free System
  • Fc
  • Avi&Fc
  • Fc&His
  • His
  • mIgG2a
  • rFc
  • mFc
  • Non
  • Flag&His
  • Flag
  • DDK&Myc
  • Avi&Fc&His
  • GST&His
  • His&Strep II
Cat.# Product name Source (Host) Species Tag Protein Length Price
CD27-493R Recombinant Rhesus CD27 protein(Met1-Ile192), hFc-tagged HEK293 Rhesus macaque Fc Met1-Ile192
CD27-57H Active Recombinant Human CD27 Protein, Fc & Avi-tagged, Biotinylated HEK293 Human Avi&Fc Thr 21 - Ile 192
Cd27-840M Active Recombinant Mouse Cd27 Protein, His & Fc-tagged HEK293 Mouse Fc&His 1-182 a.a.
CD27-180HAF488 Active Recombinant Human CD27 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 396
CD27-180HAF555 Active Recombinant Human CD27 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 396
CD27-180HAF647 Active Recombinant Human CD27 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 396
CD27-180HF Active Recombinant Human CD27 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 396
CD27-493RAF488 Active Recombinant Monkey CD27 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Monkey Fc Met1-Ile192, 413
CD27-493RAF555 Active Recombinant Monkey CD27 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Monkey Fc Met1-Ile192, 413
CD27-493RAF647 Active Recombinant Monkey CD27 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Monkey Fc Met1-Ile192, 413
CD27-493RF Active Recombinant Monkey CD27 Protein, Fc-tagged, FITC conjugated HEK293 Monkey Fc Met1-Ile192, 413
Cd27-840MAF488 Active Recombinant Mouse Cd27 Protein, His/Fc-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Fc&His 410
Cd27-840MAF555 Active Recombinant Mouse Cd27 Protein, His/Fc-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Fc&His 410
Cd27-840MAF647 Active Recombinant Mouse Cd27 Protein, His/Fc-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Fc&His 410
Cd27-840MF Active Recombinant Mouse Cd27 Protein, His/Fc-tagged, FITC conjugated HEK293 Mouse Fc&His 410
CD27-180H Recombinant Human CD27 protein, hFc-tagged HEK293 Human Fc Met1-Ile192
Cd27-3273M Active Recombinant Mouse Cd27 protein(Met1-Arg182), His-tagged HEK293 Mouse His Met1-Arg182
CD27-638H Recombinant Human CD27, Fc-His tagged Human Cells Human Fc&His 1-192 a.a.
CD27-06H Active Recombinant Human CD27 Protein, hIgG/His-tagged HEK293 Human Fc&His 20-191aa
CD27-1079HA Active Recombinant Human CD27 protein, Fc-tagged, APC-labeled HEK293 Human Fc Thr 21 - Ile 192
CD27-1079HP Recombinant Human CD27 protein, Fc-tagged, R-PE-labeled HEK293 Human Fc
CD27-152H Recombinant Human CD27 Protein, His-tagged Human Cells Human His
Cd27-3273MAF488 Recombinant Mouse Cd27 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His 173
Cd27-3273MAF555 Recombinant Mouse Cd27 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His 173
Cd27-3273MAF647 Recombinant Mouse Cd27 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His 173
Cd27-3273MF Recombinant Mouse Cd27 Protein, His-tagged, FITC conjugated HEK293 Mouse His 173
CD27-335C Recombinant Cynomolgus/Rhesus macaque CD27 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Cynomolgus/Rhesus macaque mIgG2a 172
CD27-556HAF488 Recombinant Human CD27 Protein, His-tagged, Alexa Fluor 488 conjugated Insect Cells Human His 183
CD27-556HAF555 Recombinant Human CD27 Protein, His-tagged, Alexa Fluor 555 conjugated Insect Cells Human His 183
CD27-556HAF647 Recombinant Human CD27 Protein, His-tagged, Alexa Fluor 647 conjugated Insect Cells Human His 183
CD27-556HF Recombinant Human CD27 Protein, His-tagged, FITC conjugated Insect Cells Human His 183
CD27-638HAF488 Recombinant Human CD27 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc&His 420
CD27-638HAF555 Recombinant Human CD27 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc&His 420
CD27-638HAF647 Recombinant Human CD27 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc&His 420
CD27-638HF Recombinant Human CD27 Protein, Fc/His-tagged, FITC conjugated HEK293 Human Fc&His 420
CD27-946R Recombinant Rat CD27 Protein (Met1-Arg183), HlgG1 Fc-tagged HEK293 Rat Fc Met1-Arg183
CD27-947R Recombinant Rat CD27 Protein (Met1-Cys181), MlgG2a Fc-tagged HEK293 Rat mIgG2a Met1-Cys181
CD27-001H Active Recombinant Human CD27, MIgG2a Fc-tagged CHO Human Fc
CD27-003H Active Recombinant Human CD27, HIgG1 Fc-tagged CHO Human Fc 21-192 a.a.
CD27-141H Active Recombinant Human CD27, Fc-tagged CHO Human Fc 21-192 a.a.
CD27-564H Active Recombinant Human CD27, Fc-tagged, Biotinylated Human Cells Human Fc 20-191 a.a.
Cd27-643R Active Recombinant Rat Cd27, Fc Chimera Mammalian Cells Rat Fc
CD27-1345H Acitve Recombinant Human CD27 protein(Met1-Ile192), His-tagged Insect Cells Human His Met1-Ile192
CD27-1653C Recombinant Cynomolgus CD27 protein, His-tagged C-His Cynomolgus Thr21-Ile192
CD27-3228H Active Recombinant Human CD27 protein(Met1-Ile192), rFc-tagged HEK293 Human rFc Met1-Ile192
Cd27-5654M Recombinant Mouse Cd27 protein, mFc-tagged HEK293 Mouse mFc Pro24-Arg182
CD27-1592H Recombinant Human CD27 Molecule, Fc-His Mammalian Cells Human Fc&His 1-192 a.a.
CD27-1654R Recombinant Rhesus Monkey CD27 Protein HEK293 Rhesus macaque Non 21-188 a.a.
CD27-26925TH Recombinant Human CD27 Wheat Germ Human Non 260 amino acids
Cd27-3258M Recombinant Mouse CD27 Antigen, Fc Chimera Human Cells Mouse Fc 1-189 a.a.
CD27-556H Recombinant Human CD27, His tagged Insect Cells Human Fc 1-192 a.a.
CD27-56H Recombinant Human CD27 Molecule, Fc-Tagged Human Cells Human Fc
CD27-572H Recombinant Human CD27 protein, His-tagged E.coli Human His Ser19~Asp188
CD27-7139H Recombinant Human CD27 Molecule, His-tagged E.coli Human His 21-191aa
CD27-887H Recombinant Human CD27 Protein, DDK/His-tagged HEK293 Human Flag&His 20-191 a.a.
CD27-888H Recombinant Human CD27 Protein, Fc/His-tagged HEK293 Human Fc&His
CD27-001HCL Recombinant Human CD27 cell lysate Insect Cells Human Non
CD27-1156CCL Recombinant Cynomolgus CD27 cell lysate Human Cells Cynomolgus Non
CD27-1383HCL Recombinant Human CD27 cell lysate Human Cells Human Non
CD27-2415MCL Recombinant Mouse CD27 cell lysate Human Cells Mouse Non
CAB11495RH Rabbit Anti-Human CD27 Molecule Monoclonal Antibody, FITC-conjugated Rabbit Human Non
CAB11497RH Rabbit Anti-Human CD27 Molecule Monoclonal Antibody Rabbit Human Non
CD27-079HG Active GMP Recombinant Human CD27 protein, Fc-tagged HEK293 Human Fc DNA sequence encoding Human CD27(NCBI Reference Sequence: NP_001233.1) was expressed with Fc tag at the C-terminal.
CD27-0929H Recombinant Human CD27 Protein (Thr21-Ile192), N-His tagged E.coli Human His Thr21-Ile192
CD27-1079H Recombinant Human CD27 protein, hFc-tagged HEK293 Human Fc Thr21-Ile192
CD27-1418HFL Recombinant Full Length Human CD27 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
CD27-183H Recombinant Human CD27 Protein, C-His-tagged E.coli Human His
CD27-1875R Active Recombinant Rat CD27 protein, His-tagged HEK293 Rat His Thr 21- Arg 183
Cd27-2058M Recombinant Mouse Cd27 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
CD27-223H Recombinant Human CD27 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
CD27-223H-B Recombinant Human CD27 Protein Pre-coupled Magnetic Beads HEK293 Human
CD27-229H Recombinant Human CD27 molecule Protein, Tag Free HEK293 Human Non 20-191aa
Cd27-23R Recombinant Rat Cd27 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
Cd27-23R-B Recombinant Rat Cd27 Protein Pre-coupled Magnetic Beads HEK293 Rat
CD27-2953H Recombinant Human CD27 protein, His-tagged HEK293 Human His Thr21-Ile192
CD27-2954M Active Recombinant Mouse CD27 protein, mFc-tagged HEK293 Mouse mFc Thr 21-Arg 182
CD27-2955H Active Recombinant Human CD27 protein, mFc-tagged HEK293 Human mFc Thr 21-Ile 192
CD27-324H Active Recombinant Human CD27 protein, His-tagged, Biotinylated Insect Cells Human His Met1-Ile192
CD27-336H Recombinant Human CD27 protein, His-tagged HEK293 Human His 172
CD27-337H Recombinant Human CD27 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Human mIgG2a 172
CD27-357M Recombinant Mouse CD27 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse mIgG2a 162
Cd27-365M Recombinant Mouse Cd27 Protein, His&GST-tagged E.coli Mouse GST&His Pro24-Arg182
CD27-497H Recombinant Human CD27 Protein (Ala20-Arg191), C-hFc-tagged HEK293 Human Fc Ala20-Arg191
CD27-5329H Recombinant Human CD27 Protein (Met1-Ile192), C-His tagged Mammalian Cells Human His Met1-Ile192
CD27-5330H Recombinant Human CD27 Protein (Met1-Ile192), C-Fc tagged Mammalian Cells Human Fc Met1-Ile192
CD27-54HF Recombinant Full Length Human CD27 Protein In Vitro Cell Free System Human Full L. 260 amino acids
CD27-622H Recombinant Human CD27 Protein, Fc-tagged HEK293 Human Fc 260
CD27-6271H Recombinant Human CD27 protein, His-tagged HEK293 Human His Gln39-Pro193
CD27-6351H Recombinant Human CD27 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Cd27-643G Recombinant Golden hamster Cd27 protein, His&Strep II-tagged E.coli Golden hamster His&Strep II 21-187a.a.
RFL20496MF Recombinant Full Length Mouse Cd27 Antigen(Cd27) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (24-250)
RFL31933HF Recombinant Full Length Human Cd27 Antigen(Cd27) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (20-260)

    Involved Pathway

    Cd27 involved in several pathways and played different roles in them. We selected most pathways Cd27 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction LEPR,IFNG1-2,CCR8L,IL15,PRL,IL22RA2,IL23R,IL1B,INHBE,TNFRSF10C

    Protein Function

    Cd27 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process,protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd27 itself. We selected most functions Cd27 had, and list some proteins which have the same functions with Cd27. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process C1QL4L,SNCA,TFAP2B,BIRC7,RPS6KA3,BIRC5,ARRB1,PRDX5,IGF1RB,SERPINB9
    tumor necrosis factor-activated receptor activity TNFRSF8,TNFRSF9A,TNFRSF1B,TNFRSF25,HDR,RELT,TNFRSF11B,NGFRB,TNFRSF6B,TNFRSF14
    transmembrane signaling receptor activity KLRF1,IL27RA,NRXN2,Cd79a,KIR2DL4,BAI2,EBP,FZD7A,VIPR1B,KLRC2
    protein binding OTUB1,HLCS,DERL2,CASP8,KRT33B,CDKN2AIP,COA3,MTIF3,CYB5R2,TAF2

    Interacting Protein

    Cd27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd27 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd27.

    SIVA1;UHRF2;TRAF2

    Cd27 Related Signal Pathway

    Resources

    Gene Families

    Cytokines

    Research Area

    Cancer Drug Targets
    Natural Killer Cells (NK Cells) Markers
    Natural Killer (NK) Cell CD Antigen
    Co-stimulatory TNF Superfamily Molecules
    Cytotoxic T Cells (CTLs)
    gamma delta T Cells
    CD Antigen (Regulatory T Cells)
    TNF Receptor
    Co-stimulatory Molecules
    Myeloma Cancer Stem Cell Markers
    Immune Checkpoints

    References

    • Convers, KD; Kariuki, BM; et al. Decreased CD5(-)CD19(+)CD27(+)CD43(+)CD70(-) B-Cell Subpopulation in Children with Specific Antibody Deficiency. PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY 28:27-31(2015).
    • Becerra, E; Scully, MA; et al. Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 179:414-425(2015).

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