Active Recombinant Human CD27, HIgG1 Fc-tagged
| Cat.No. : | CD27-003H |
| Product Overview : | The extracellular domain of human CD27[TNFRSF7] (AAH12160.1)( Thr21- Ile192) is fused to the N-terminus of the Fc region of human IgG1. |
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| Description : | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor |
| Source : | CHO cells |
| Species : | Human |
| Tag : | HIgG1 Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Measured by its ability to inhibit the proliferation of mouse T cells induced by CD27 Ligand and anti-CD3. |
| Molecular Mass : | 45 KDa (monomer) |
| AA Sequence : | Thr21- Ile192 |
| Endotoxin : | <0.06 eu/μg="" as="" determined="" by="" lal="" test.=""> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Protein length : | 21-192 a.a. |
| Gene Name | CD27 CD27 molecule [ Homo sapiens ] |
| Official Symbol | CD27 |
| Synonyms | CD27; CD27 molecule; TNFRSF7, tumor necrosis factor receptor superfamily, member 7; CD27 antigen; S152; Tp55; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7; T14; TNFRSF7; MGC20393; |
| Gene ID | 939 |
| mRNA Refseq | NM_001242 |
| Protein Refseq | NP_001233 |
| MIM | 186711 |
| UniProt ID | P26842 |
| Chromosome Location | 12p13 |
| Pathway | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
| Function | cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; receptor activity; transmembrane signaling receptor activity; |
Not For Human Consumption!
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