Active Recombinant Human CD27, MIgG2a Fc-tagged

• Cat.No.: CD27-001H
• Product Overview: The extracellular domain of human CD27[TNFRSF7] (AAH12160.1)( Thr21- Ile192) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO celL

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required forgeneration and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role inregulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to theactivation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signalingprocess of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and isthought to play an important role in the apoptosis induced by this receptor.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit the proliferation of mouse T cells induced by CD27 Ligand and anti-CD3.
• Molecular Mass: 45 KDa (monomer)
• AA Sequence: Thr21- Ile192
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: CD27 CD27 molecule [ Homo sapiens ]
• Official Symbol: CD27
• Synonyms: CD27; CD27 molecule; TNFRSF7, tumor necrosis factor receptor superfamily, member 7; CD27 antigen; S152; Tp55; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7; T14; TNFRSF7; MGC20393
• Gene ID: 939
• mRNA Refseq: NM_001242
• Protein Refseq: NP_001233
• MIM: 186711
• UniProt ID: P26842
• Chromosome Location: 12p13
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; receptor activity; transmembrane signaling receptor activity