Recombinant Mouse CD27 Antigen, Fc Chimera

• Cat.No.: Cd27-3258M
• Product Overview: Recombinant mouse Cd27 protein (Met 1-Ile 189), fused with the Fc region of human IgG1 at the C-terminus, was expressed inHuman Cells.

Specification

• Species: Mouse
• Source: Human Cells
• Tag: Fc
• Protein Length: 1-189 a.a.
• Description: Mouse CD27, also known as TNFRSF7, is a member of the tumor necrosis factor receptor (TNFR) superfamily characterized by the presence of a Cys-knot motif in the extracellular region, which occurs three times in CD27. CD27 is a type I transmembrane glycoprotein existing as disulfide-linked homodimer, and has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis. CD27 has been defined as a T and B cell co-stimulatory molecule, and its activity is governed by the transient availability of its TNF-like ligand CD70 on lymphocytes and dendritic cells. In man and mouse, CD27 is restricted to lymphoid cells and present on the great majority of naive CD4+ and CD8+ T cells.
• Molecular Mass: The recombinant mouse CD27/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 410 amino acids and has a predicted molecular mass of 46.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CD27/Fc monomer is approximately 60-65 kDa due to glycosylation.
• Predicted N Terminal: Thr 21.
• Purity: > 94 % as determined by SDS-PAGE.
• Formulation: Lyophilized from sterile PBS , pH 7.4.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Storage And Stability: Samples are stable for up to twelve months from date of receipt at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Cd27 CD27 antigen [ Mus musculus ]
• Synonyms: Cd27; CD27 antigen; S152; Tp55; Tnfrsf7; CD27 antigen; CD antigen 27; CD27L receptor; OTTMUSP00000029268; OTTMUSP00000029269; OTTMUSP00000029270; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
• Gene ID: 21940
• mRNA Refseq: NM_001033126
• Protein Refseq: NP_001028298
• UniProt ID: P41272
• Chromosome Location: 6 F3; 6 60.35 cM
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity