BCL2
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Official Full Name
B-Cell CLL/Lymphoma 2 -
Overview
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. -
Synonyms
BCL2;B-cell CLL/lymphoma 2;Bcl-2;apoptosis regulator Bcl-2;PPP1R50
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Dog
- Cricetulus griseus
- Mus musculus
- Bovine
- E.coli
- Wheat Germ
- Mammalian Cells
- E.Coli/Yeast
- Human (minus BH1 domain)
- Human (minus BH3 domain)
- Human (minus NWGR domain)
- In Vitro Cell Free System
- HEK293
- GST
- His
- His&T7
- DDK&Myc
- Non
- His&SUMO
- Avi&Fc&His
- Flag
Involved Pathway
BCL2 involved in several pathways and played different roles in them. We selected most pathways BCL2 participated on our site, such as NF-kappa B signaling pathway,HIF- signaling pathway,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cholinergic synapse | GNG8,PIK3CA,GNG12,GNAI1,CAMK2B,CAMK2G,GNG7,CHRM3,PIK3CG,CAMK4 |
| Hepatitis B | FOS,MAP2K2,Fasl,FADD,Ifna11,NFATC4,BIRC5,TRP53,IFNA1,NFKB1 |
| Tuberculosis | IFNA12,MRC2,IFNA5,ATP6V0B,IL10RA,TLR1,IL6,HLA-DOA,CD209C,ITGAM |
| Epstein-Barr virus infection | POLR2F,POLR2I,NFKBIA,HSPA6,HLA-DQA1,POLR3GL,RBPJ,HLA-DPA1,RELB,HSPA2 |
| Sphingolipid signaling pathway | S1PR5,MAPK13,PRKCA,GNAI2,PIK3R5,PPP2CB,MAPK10,PIK3R1,MAP2K1,BDKRB2 |
| Focal adhesion | PPP1CAB,COL5A2A,RAC3B,PXN,COL2A1B,THBS4A,ITGA9,PIK3CD,VTNB,FLNB |
| Small cell lung cancer | RELA,IKBKB,NOS2,BIRC2,MAX,APAF1,NFKBIA,ITGA3,BIRC3,TRAF4 |
| Jak-STAT signaling pathway | NT5C3,EPO,AKT1,IL20,IL20RB,IL15,IL-15RA,PIK3R2,PIK3CA,LEPB |
| Pathways in cancer | GNG3,EGLN1,MAPK10,NFKB1,PLCG1,Shh,IGF1R,GNB2,GNG8,BRAF |
Protein Function
BCL2 has several biochemical functions, for example, BH3 domain binding,channel activity,channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2 itself. We selected most functions BCL2 had, and list some proteins which have the same functions with BCL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | RARA,MYOG,EXT1,JAM2A,HIST1H2BP,SMAD4,TOP2B,TAF9B,NFYBB,TGFB1 |
| channel activity | PANX1A,BAXA,BAXB,STEAP1,TRPA1,PANX2,P2RX6,BAX,APNL,GJA8 |
| BH3 domain binding | BCL2L1,BAX,MCL1 |
| protein binding | FZR1,SURF1,ATP1B1,RHOB,PXN,FAM134C,RNPS1,MSX2,RPS6KB1,ANXA10 |
| protein homodimerization activity | KCNE2,CHUK,GSTM2,VPS4B,BCL2L1,TYR,PDGFRA,PGCP,ABCB10,IKZF4 |
| protein phosphatase 2A binding | TRP53,TP53,SMG7,RPS6KB1,PPP2R2A,SPHK1,GRIN3A,ENSA,SMG5,PPME1 |
| identical protein binding | RUNX1T1,CBS,RELA,PRPS2,CBX3,VPS41,EWSR1,GCC2,VCP,CEP72 |
| protease binding | COMP,SELL,MBL1,CD70,CHL1,DPP4,LRP1,F3,TRIP4,TIMP2 |
| transcription factor binding | CTBP1,NFATC2,GTF2F1,FIGLA,TFDP1A,FOXO4,PPP1R13BB,ID1,MYBBP1A,TBX5 |
Interacting Protein
BCL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2.
BECN1;BAX
BCL2 Related Signal Pathway
Resources
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References
- Marguet, F; Bergogne, L; et al. Fetal presentation of congenital fibrosarcoma of the meninges: case report and literature review. CLINICAL NEUROPATHOLOGY 34:70-75(2015).
- Abdel-Latif, M; Sakran, T; et al. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. INTERNATIONAL IMMUNOPHARMACOLOGY 24:173-181(2015).
Reviews
We got good loading on our sensor with the protein. Do you have more of this protein in stock and would it be possible for us to get another quote for this protein?
