Recombinant Human BCL2, GST-tagged

• Cat.No.: BCL2-6976H
• Product Overview: Recombinant full-length human BCL2 was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Description: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
• Source: E.coli
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~51kDa
• Applications: Western Blot
• Stability: 1 yr at -70°C from date of shipment.
• Storage: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 ug/ul

Gene Information

• Gene Name: BCL2 B-cell CLL/lymphoma 2 [ Homo sapiens (human) ]
• Official Symbol: BCL2
• Synonyms: Bcl-2; OTTHUMP00000163680; BCL2; B-cell CLL/lymphoma 2; B-cell lymphoma protein 2; apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50
• Gene ID: 596
• mRNA Refseq: NM_000633
• Protein Refseq: NP_000624
• MIM: 151430
• UniProt ID: P10415
• Chromosome Location: 18q21.3
• Pathway: ATF-2 transcription factor network; Activation of BH3-only proteins; Adrenergic signaling in cardiomyocytes
• Function: BH3 domain binding; channel inhibitor activity; identical protein binding