NTRK1

  • Official Full Name

    neurotrophic tyrosine kinase, receptor, type 1

  • Overview

    This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

  • Synonyms

    NTRK1;neurotrophic tyrosine kinase, receptor, type 1;MTC;TRK;TRK1;TRKA;Trk-A;p140-TrkA;high affinity nerve growth factor receptor;gp140trk;Oncogene TRK;tyrosine kinase receptor A;tropomyosin-related kinase A;TRK1-transforming tyrosine kinase protein

Recombinant Proteins

  • Rat
  • Human
  • Canine
  • Dog
  • Mouse
  • Rabbit
  • Chicken
  • Zebrafish
  • HEK293
  • E.coli
  • Mammalian cells
  • Human Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Insect Cell
  • HEK293T
  • E.coli expression system
  • His
  • His&Fc
  • Fc
  • C-His&hFc
  • His&Flag
  • Non
  • GST
  • Flag
  • Myc&DDK
  • His&Fc&Avi
  • mFc
Cat.# Product name Source (Host) Species Tag Protein Length Price
NTRK1-03R Active Recombinant Rat NTRK1 protein, His-tagged HEK293 Rat His 35-418aa
NTRK1-156H Recombinant Human NTRK1, His tagged HEK293 Human His Met 1-Pro 382
NTRK1-295C Active Recombinant Canine NTRK1, His tagged HEK293 Canine His Pro285-Lys410
NTRK1-973H Active Recombinant Human NTRK1, His tagged E.coli Human His Pro 285-Glu 413
NTRK1-977H Active Recombinant Human NTRK1 protein, His-tagged HEK293 Human His Pro194-Glu413
NTRK1-155HAF488 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human His&Fc 598
NTRK1-155HAF555 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human His&Fc 598
NTRK1-155HAF647 Recombinant Human NTRK1 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human His&Fc 598
NTRK1-155HF Recombinant Human NTRK1 Protein, Fc/His-tagged, FITC conjugated HEK293 Human His&Fc 598
NTRK1-156HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 361
NTRK1-156HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 361
NTRK1-156HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 361
NTRK1-156HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 Human His 361
NTRK1-295CAF488 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Dog His 146
NTRK1-295CAF555 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Dog His 146
NTRK1-295CAF647 Recombinant Canine NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Dog His 146
NTRK1-295CF Recombinant Canine NTRK1 Protein, His-tagged, FITC conjugated HEK293 Dog His 146
NTRK1-296CAF488 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Dog Fc 386
NTRK1-296CAF555 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Dog Fc 386
NTRK1-296CAF647 Recombinant Canine NTRK1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Dog Fc 386
NTRK1-296CF Recombinant Canine NTRK1 Protein, Fc-tagged, FITC conjugated HEK293 Dog Fc 386
NTRK1-3080H Recombinant Human NTRK1 protein, His-tagged E.coli Human His 80-277 aa
NTRK1-415MAF488 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His 398
NTRK1-415MAF555 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His 398
NTRK1-415MAF647 Recombinant Mouse Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His 398
NTRK1-415MF Recombinant Mouse Ntrk1 Protein, His-tagged, FITC conjugated HEK293 Mouse His 398
Ntrk1-44RAF488 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Rat Fc 627
Ntrk1-44RAF555 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Rat Fc 627
Ntrk1-44RAF647 Recombinant Rat Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Rat Fc 627
Ntrk1-44RF Recombinant Rat Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Rat Fc 627
Ntrk1-45RAF488 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Rat His 397
Ntrk1-45RAF555 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Rat His 397
Ntrk1-45RAF647 Recombinant Rat Ntrk1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Rat His 397
Ntrk1-45RF Recombinant Rat Ntrk1 Protein, His-tagged, FITC conjugated HEK293 Rat His 397
NTRK1-476MAF488 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Fc 628
NTRK1-476MAF555 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Fc 628
NTRK1-476MAF647 Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Fc 628
NTRK1-476MF Recombinant Mouse Ntrk1 Protein, Fc-tagged, FITC conjugated HEK293 Mouse Fc 628
NTRK1-509RAF488 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Rabbit His Ala33-Glu414， 393
NTRK1-509RAF555 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Rabbit His Ala33-Glu414， 393
NTRK1-509RAF647 Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Rabbit His Ala33-Glu414， 393
NTRK1-509RF Recombinant Rabbit NTRK1 Protein, His-tagged, FITC conjugated HEK293 Rabbit His Ala33-Glu414， 393
NTRK1-973HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated E.coli Human His 136
NTRK1-973HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated E.coli Human His 136
NTRK1-973HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated E.coli Human His 136
NTRK1-973HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated E.coli Human His 136
NTRK1-977HAF488 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 239
NTRK1-977HAF555 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 239
NTRK1-977HAF647 Recombinant Human NTRK1 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 239
NTRK1-977HF Recombinant Human NTRK1 Protein, His-tagged, FITC conjugated HEK293 Human His 239
NTRK1-166H Active Recombinant Human NTRK1, Fc Chimera Mammalian cells Human Fc
NTRK1-1322C Acitve Recombinant Canine NTRK1 protein(Pro285-Lys410), hFc-tagged HEK293 Canine Fc Pro285-Lys410
NTRK1-1352R Acitve Recombinant Rat NTRK1 protein(Met1-Pro418), hFc-tagged HEK293 Rat Fc Met1-Pro418
NTRK1-108H Recombinant Human NTRK1, Fc Chimera HEK293 Human Fc
NTRK1-155H Active Recombinant Human NTRK1 protein(Met1-Pro382), His&hFc-tagged HEK293 Human C-His&hFc Met1-Pro382
NTRK1-296C Recombinant Canine NTRK1, Fc tagged Human Cell Canine His&Fc 285-410 a.a.
NTRK1-296H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 Human His&Flag Ala33-Gly417
NTRK1-297H Recombinant Human NTRK1 Protein, DDK/His-tagged HEK293 Human His&Flag Ala33-Gly423
NTRK1-31618TH Recombinant Human NTRK1 Human Non 440-end a.a.
NTRK1-31619TH Recombinant Human NTRK1, Fc-tagged Human Fc 33-405 a.a.
NTRK1-4102R Recombinant Rat NTRK1 Protein Mammalian Cell Rat His
NTRK1-415M Active Recombinant Mouse NTRK1 protein(Met1-Gly420), His-tagged HEK293 Mouse His Met1-Gly420
NTRK1-448H Recombinant Human NTRK1, GST-tagged, Active Sf9 Insect Cell Human GST 440-end a.a.
Ntrk1-44R Recombinant Rat Ntrk1, Fc tagged Human Cell Rat His 1-418 a.a.
Ntrk1-45R Active Recombinant Rat Ntrk1 protein(Met1-Pro418), His-tagged HEK293 Rat His Met1-Pro418
NTRK1-476M Recombinant Mouse Ntrk1, Fc tagged Human Cell Mouse His 1-420 a.a.
NTRK1-495H Recombinant Human NTRK1, Fc-tagged Mammalian cells Human Fc 33-407 a.a.
Ntrk1-589R Recombinant Rat TrkA, FC Chimera Mammalian cells Rat Fc
NTRK1-6930C Recombinant Chicken NTRK1 Mammalian Cell Chicken His
NTRK1-717H Recombinant Human NTRK1, GST-His Sf9 Insect Cell Human GST 443-796 a.a.
NTRK1-8470Z Recombinant Zebrafish NTRK1 Mammalian Cell Zebrafish His
NTRK1-86H Recombinant Human NTRK1 protein, Flag-tagged, Biotinylated Insect Cell Human Flag 436-790 a.a.
NTRK1-1068RCL Recombinant Rat NTRK1 cell lysate Human Cell Rat Non
NTRK1-1086MCL Recombinant Mouse NTRK1 cell lysate Human Cell Mouse Non
NTRK1-2147HCL Recombinant Human NTRK1 cell lysate Human Cell Human Non
NTRK1-963CCL Recombinant Canine NTRK1 cell lysate Human Cell Canine Non
NTRK1-01H Active Recombinant Human NTRK1 Protein (34-407), Animal free HEK293 Human 34-407
NTRK1-1225H Recombinant Human NTRK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
NTRK1-130H Recombinant Human NTRK1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
NTRK1-130H-B Recombinant Human NTRK1 Protein Pre-coupled Magnetic Beads HEK293 Human
NTRK1-1505HFL Recombinant Full Length Human NTRK1 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
NTRK1-163N Active Recombinant Human NTRK1 Protein HEK293 Human
Ntrk1-16R Recombinant Rat Ntrk1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
Ntrk1-16R-B Recombinant Rat Ntrk1 Protein Pre-coupled Magnetic Beads HEK293 Rat
NTRK1-1971M Active Recombinant Mouse NTRK1 protein, hFc-tagged HEK293 Mouse Fc Met1-Gly420
NTRK1-2030H Recombinant Human NTRK1 Protein, Fc/His-tagged HEK293 Human His&Fc Ala33-Glu407
NTRK1-2514H Recombinant Human NTRK1 Protein, His-tagged E.coli Human His Val278-Asn386
NTRK1-260H Recombinant Active Human NTRK1 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Human His&Fc Ala33-Glu407
Ntrk1-4522M Recombinant Mouse Ntrk1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
NTRK1-496H Recombinant Human NTRK1 protein, mFc-tagged HEK293 Human mFc Gly 192 - Val 402
NTRK1-497H Recombinant Human NTRK1 protein, mFc-tagged HEK293 Human mFc Ala 33 - Gly 417
NTRK1-509R Active Recombinant Rabbit NTRK1 protein, His-tagged HEK293 Rabbit His 33-414 a.a.
RFL27953HF Recombinant Full Length Human High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (33-796)
RFL29589RF Recombinant Full Length Rat High Affinity Nerve Growth Factor Receptor(Ntrk1) Protein, His-Tagged E.coli expression system Rat His Full L. Full Length of Mature Protein (33-799)

    Involved Pathway

    NTRK1 involved in several pathways and played different roles in them. We selected most pathways NTRK1 participated on our site, such as MAPK signaling pathway,Endocytosis,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis TNF,PLEC,TRADD,CAPN2,DYNLL2,CAPN2L,AKT3A,IRF4A,Fasl,BIDA
    Central carbon metabolism in cancer PDHA1,HK1,KIT,PDK1,SLC2A2,GLS2,GLS,RET,PIK3CG,PFKM
    Endocytosis TGFBR1B,PDCD6IP,LDLRAP1B,ASAP2A,ACAP2,PIP5K1BB,ERBB4A,WWP1,VPS25,RAB22A
    Transcriptional misregulation in cancer SFPI1,TMPRSS2,CD86,SSX2,BMP2K,FUS,FLI1,MLL1,TSPAN7,RUNX2
    Pathways in cancer FGF3,BIRC2,CKS2,STK36,GNA11,BID,CASP9,MTOR,BCL2L1,WNT2B
    Thyroid cancer NCOA4,PPARG,CCND1,RET,TCF7,TPR,MAP2K1,RXRB,TCF7L2,NRAS
    Neurotrophin signaling pathway IRS1,FOXO3,SH2B2,CALM3,PIK3CB,PRDM4,MAPK1,MAGED1,YWHAE,PDPK1
    MAPK signaling pathway PRKACAB,MEF2CA,FLNC,ATF4,FGF9,FGF1,NRAS,GADD45BA,Fgf15,FGF11
    Inflammatory mediator regulation of TRP channels ASIC5,KLK1B4,PLCB4,PPP1CC,PRKACB,PLCG2,PRKACA,TRPA1,PIK3CG,MAP2K3

    Protein Function

    NTRK1 has several biochemical functions, for example, ATP binding,ephrin receptor binding,kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK1 itself. We selected most functions NTRK1 had, and list some proteins which have the same functions with NTRK1. You can find most of the proteins on our site.

    Function Related Protein
    transmembrane receptor protein tyrosine kinase activity KIT,FLT4,EPHB3A,INSRR,EPHB2B,RET,ERBB3B,ROR1,CADM2B,NPTNB
    ATP binding PTK6,PEBP1,ABCG5,ERCC6,PET112L,Adcy4,CCT8L2,CMPK,MADD,MYHZ1.2
    protein binding TMCO6,CD8B,SMARCB1,IQSEC3,ARHGAP5,CTBP1,MAP3K5,SCG2,PAAF1,CADPS
    neurotrophin p75 receptor binding NTF3,ZFP110,NRADD
    protein homodimerization activity NAGA,CHMP4C,IKZF2,GTF2A2,PPP2R4,HAND1,LRP4,VAPB,DAPK3,LRP6
    nerve growth factor binding FURIN,NGFRB,NGFR,PCSK6,SORT1
    nerve growth factor receptor activity SORT1
    kinase binding RB1,CAB39,PPP2R5A,LDHB,CDC6,SLC2A1,PRKCD,STRADA,PER1,MOB4
    ephrin receptor binding GRB2,Anks1,EFNB1,SHC1,CHN1,PIK3CG,SRC,NTRK3,EFNB2,PTPN1

    Interacting Protein

    NTRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK1.

    NGF;NGF;Pirb;PLCG1;PIK3R1;SHC1;SORT1;PTPRC;PTPN1

    Resources

    References

    • Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
    • Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).

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