Recombinant Human NTRK1, Fc-tagged
Cat.No. : | NTRK1-495H |
Product Overview : | Recombinant Human NTRK1 encoding the signal peptide from human CD33 joined with the extracellular domain of human Trk A (Ala 33 - Glu 407) was fused to the Fc region of human IgG1 via a polypeptide linker and expressed inNSO cells. |
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Species : | Human |
Source : | Mammalian Cells |
Tag : | Fc |
Protein Length : | 33-407 a.a. |
Description : | This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. |
Molecular Weight : | The predicted molecular weight of Recombinant Human is Mr 67.4 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 115-125 kDa. |
State Of Matter : | Lyophilized. |
Formulation : | This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Biological Activity : | The biological activity of Human TrkA was determined by its ability to inhibit NGF-induced proliferation of TF1 cells. The ED50 for this effect is typically 0.8 - 4 μg/mL in the presence of 10 ng/mL of rhNGF. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name | NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ] |
Synonyms | NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; p140-TrkA; DKFZp781I14186; Oncogene TRK; tyrosine kinase receptor A; high affinity nerve growth factor receptor; EC 2.7.10.1; OTTHUMP00000038736; Trk-A; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein |
Gene ID | 4914 |
mRNA Refseq | NM_001007792 |
Protein Refseq | NP_001007793 |
MIM | 191315 |
UniProt ID | P04629 |
Chromosome Location | 1q21-q22 |
Pathway | Apoptosis; Endocytosis; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer; Signalling by NGF |
Function | ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity |
◆ Recombinant Proteins | ||
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NTRK1-497H | Recombinant Human NTRK1 protein, mFc-tagged | +Inquiry |
NTRK1-509RAF488 | Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated | +Inquiry |
NTRK1-476MAF647 | Recombinant Mouse Ntrk1 Protein, Fc-tagged, Alexa Fluor 647 conjugated | +Inquiry |
NTRK1-1225H | Recombinant Human NTRK1 Protein, Myc/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Cell & Tissue Lysates | ||
NTRK1-1086MCL | Recombinant Mouse NTRK1 cell lysate | +Inquiry |
NTRK1-963CCL | Recombinant Canine NTRK1 cell lysate | +Inquiry |
NTRK1-2147HCL | Recombinant Human NTRK1 cell lysate | +Inquiry |
NTRK1-1068RCL | Recombinant Rat NTRK1 cell lysate | +Inquiry |
Not For Human Consumption!
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