Recombinant Human NTRK1 Protein, His-tagged

Specification
Gene Information
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Description :	This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Source :	E. coli
Species :	Human
Tag :	His
Form :	Freeze-dried powder
Molecular Mass :	Predicted Molecular Mass: 15.8 kDa Accurate Molecular Mass: 16 kDa
Protein length :	Val278-Asn386
Endotoxin :	<1.0 EU per 1µg (determined by the LAL method).
Purity :	> 90%
Applications :	Positive Control; Immunogen; SDS-PAGE; WB.
Stability :	The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage :	Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer :	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution :	Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Name	NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens (human) ]
Official Symbol	NTRK1
Synonyms	NTRK1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; MTC; TRK; TRKA; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein; TRK1; Trk-A; p140-TrkA; DKFZp781I14186;
Gene ID	4914
mRNA Refseq	NM_001007792
Protein Refseq	NP_001007793
MIM	191315
UniProt ID	P04629