Recombinant Human NTRK1 Protein, DDK/His-tagged

• Cat.No.: NTRK1-296H
• Product Overview: Recombinant Human NTRK1(Ala33-Gly417), transcript variant 1, fused with DDK/His tag at C-terminal was expressed in HEK293.

Specification

• Description: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
• Source: HEK293
• Species: Human
• Tag: His&Flag
• Form: 1 x PBS, pH7.4, 10% glycerol
• Molecular Mass: 45 kDa
• Protein length: Ala33-Gly417
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ]
• Official Symbol: NTRK1
• Synonyms: NTRK1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; MTC; TRK; TRKA; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein; TRK1; Trk-A; p140-TrkA; DKFZp781I14186
• Gene ID: 4914
• mRNA Refseq: NM_001012331
• Protein Refseq: NP_001012331
• MIM: 191315
• UniProt ID: P04629