Recombinant Human NTRK1, GST-His

• Cat.No.: NTRK1-717H
• Product Overview: Recombinant Human NTRK1, C-terminal fragment, amino acids G443-G796, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9insect cells.MW = 69,726 Da.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 443-796 a.a.
• Description: TrkA is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor, or "NGF". As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival.
• Purification: One-step affinity purification using GSH-agarose.
• Product Identity: TRK-A was confirmed as TRK-A by by mass spectroscopy LC-ESIMS/MS (Protagen AG, Germany).
• Storage Buffer: 50 mM HEPES-NaOH, pH 7.5; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
• Concentration: 0.133 μg/μl (Bradford method using BSA [Sigma, cat# A-7638, Lot 79H7641] as standard protein).
• Specific Activity: 29 pmol/μg×min.
• Storage: -80°C. Avoid repeated freeze-thaw cycles!

Gene Information

• Gene Name: NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ]
• Synonyms: NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; p140-TrkA; DKFZp781I14186; Trk-A; Oncogene TRK; tyrosine kinase receptor A; high affinity nerve growth factor receptor; EC 2.7.10.1
• Gene ID: 4914
• mRNA Refseq: NM_001007792
• Protein Refseq: NP_001007793
• MIM: 191315
• UniProt ID: P04629
• Chromosome Location: 1q21-q22
• Pathway: Apoptosis; Endocytosis; MAPK signaling pathway; Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer; Signalling by NGF
• Function: ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity