Active Recombinant Human NTRK1 Protein (34-407), Animal free

• Cat.No.: NTRK1-01H
• Product Overview: Active Recombinant Human NTRK1 Protein (34-407) without tag was expressed in HEK293. Animal free

Specification

• Species: Human
• Source: HEK293
• Protein Length: 34-407
• Description: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
• Form: Lyophilized
• Bio-activity: Fully biologically active determined by its ability to inhibit NGF-beta dependent proliferation of TF-1 cells. ED50 is ≤ 242.2 ng/mL, corresponding to a specific activity of 4.13 × 10^3 units/mg.
• Molecular Mass: 41 kDa
• AA Sequence: APCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDP
• Endotoxin: <= 0.005 Eu/μg
• Purity: >= 95% HPLC
• Applications: MS, HPLC, SDS-PAGE, Functional Studies
• Notes: This product is an active protein and may elicit a biological response in vivo, handle with caution.
• Storage: Store at Room Temperature.
• Storage Buffer: 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Monobasic dihydrogen potassium phosphate, 10.26% Trehalose, pH: 7.40
• Reconstitution: Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80 centigrade for 12 months or 4 centigrade for 1 week. Avoid repeated freeze-thaw.
• Shipping: Shipped at Room Temperature.

Gene Information

• Gene Name: NTRK1 neurotrophic receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: NTRK1
• Synonyms: NTRK1; neurotrophic receptor tyrosine kinase 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; Oncogene TRK; TRK1-transforming tyrosine kinase protein; gp140trk; neurotrophic tyrosine kinase, receptor, type 1; tropomyosin receptor kinase A; tropomyosin-related kinase A; tyrosine kinase receptor A; EC 2.7.10.1
• Gene ID: 4914
• mRNA Refseq: NM_002529
• Protein Refseq: NP_002520
• MIM: 191315
• UniProt ID: P04629