Recombinant Rat TrkA, FC Chimera

• Cat.No.: Ntrk1-589R
• Product Overview: Recombinant Rat TrkA was expressed inNSOCells.The recombinant mature human Trk A/Fc is a disulfide-linked homodimeric protein, Based on N-terminal.

Specification

• Species: Rat
• Source: Mammalian Cells
• Tag: Fc
• Description: A DNA sequence encoding the signal peptide from human CD33 joined with the extracellular domain of human TrkA was fused to the Fc region of human IgG1 via a polypeptide linker.
• Purity: > 95%, as determined by SDS-PAGE and visualized by silver stain.
• Endotoxin: < 1.0 EU per 1 μg of the enzyme as determined by the LAL method. Measured by its ability to inhibit NGF-induced proliferation of TF1 cells. The ED50 for this effect is typically 0.8-4 μg/mL in the presence of 10 ng/mL of rhNGF. The cell number is assessed in a fluorometric assay using a redox sensitive dye,
• Format: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.
• Storage: Lyophilized samples are stable for up to six months at -20℃to -70℃. Upon reconstitution, this cytokine, in the presence of a carrier protein, can be stored under sterile conditions at 2 -8℃ for one month or at -20℃ to -70℃in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 [ Rattus norvegicus ]
• Synonyms: Ntrk;neurotrophic tyrosine kinase, receptor, type 1;Trk; Ntrk1;trk;trk-A;p140-TrkA;trkA proto-oncogene receptor;slow nerve growth factor receptor;high affinity nerve growth factor receptor
• Gene ID: 59109
• mRNA Refseq: NM_021589
• Protein Refseq: NP_067600
• UniProt ID: P35739.1
• Chromosome Location: 2q34
• Pathway: Endocytosis;MAPK signaling pathway;Neurotrophin signaling pathway; Pathways in cancer; Thyroid cancer
• Function: protein binding