MSLN

  • Official Full Name

    mesothelin

  • Overview

    Membrane-anchored forms of mesothelin may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation. Mesothelin interacts with MUC16. The protein is expressed in lung and at low levels in the heart, placenta, kidney, and mesothelial cells. Mestothelin is highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). Both MPF and the cleaved form of mesothelin are N-glycosylated. It is proteolytically cleaved by a furin-like convertase to generate megakaryocyte- potentiating factor (MPF), and the cleaved form of mesothelin.

  • Synonyms

    MPF;SMRP;CAK1 antigen;megakaryocyte potentiating factor;pre-pro-megakaryocyte-potentiating factor;soluble MPF mesothelin related protein

Recombinant Proteins

  • Human
  • Mouse
  • Cynomolgus
  • Rat
  • Human cells
  • Human Cell
  • HEK293
  • E.coli
  • Mammalian cells
  • CHO
  • CHO cells
  • NS0
  • Mammalian Cell
  • HEK293F
  • HEK293T
  • Yeast
  • Wheat Germ
  • In Vitro Cell Free System
  • Fc
  • His
  • Non
  • GST
  • His&Avi
  • C-hFc-Avi
  • Fc&Avi
  • Myc&DDK
  • His&GST
  • His&Fc&Avi
  • His&Myc
  • His&mFc
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
MSLN-10625H Active Recombinant Human MSLN Protein, Fc-tagged Human cells Human Fc 296-592 a.a.
MSLN-642H Active Recombinant Human MSLN, His-tagged, Biotinylated Human Cell Human His 296-592 a.a.
MSLN-001H Active Recombinant Human MSLN Protein, His-tagged HEK293 Human His 296-592 a.a.
MSLN-10625HAF488 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 296-592 a.a.
MSLN-10625HAF555 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 296-592;534-o a.a.
MSLN-10625HAF647 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 296-592 a.a.
MSLN-10625HF Active Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 534-o a.a.
MSLN-316H Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), Fc-tagged, FITC-Labeled HEK293 Human Fc Glu 296 - Gly 580
MSLN-528HAF488 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc Glu296-Ser592
MSLN-528HAF555 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc Glu296-Ser592
MSLN-528HAF647 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc Glu296-Ser592
MSLN-528HF Active Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Human Fc Glu296-Ser592
MSLN-8392H Active Recombinant Human MSLN Protein Human cells Human Non 296-592 a.a.
MSLN-01H Recombinant Human Mesothelin HEK293 Human Non 1-398 a.a.
MSLN-1062H Recombinant Human MSLN, GST-tagged E.coli Human GST 273-621aa
Msln-34M Recombinant Mouse Msln protein, His-tagged E.coli Mouse His Pro345~Asn548
MSLN-10625HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Human Fc
MSLN-185HAF488 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 545
MSLN-185HAF555 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 545
MSLN-185HAF647 Active Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 545
MSLN-185HF Active Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 545
MSLN-25C Recombinant Cynomolgus MSLN Protein, Fc tagged Human cells Cynomolgus Fc
MSLN-26C Recombinant Cynomolgus MSLN Protein, C-His tagged Human cells Cynomolgus His
MSLN-303H Recombinant Human MSLN protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi Glu296-Gly580
MSLN-304H Recombinant Human MSLN protein, hFc-Avi-tagged, Biotinylated HEK293 Human C-hFc-Avi Glu296-Gly580
MSLN-318H Recombinant Human MSLN Protein (Glu 296 - Gly 580), His-tagged, PE-Labeled HEK293 Human His Glu 296 - Gly 580
MSLN-340HAF488 Recombinant Human MSLN Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc Glu296-Gly580
MSLN-340HAF555 Recombinant Human MSLN Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc Glu296-Gly580
MSLN-340HAF647 Recombinant Human MSLN Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc Glu296-Gly580
MSLN-340HF Recombinant Human MSLN Protein, hFc-tagged, FITC conjugated HEK293 Human Fc Glu296-Gly580
MSLN-7350HAF488 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 491
MSLN-7350HAF555 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 491
MSLN-7350HAF647 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 491
MSLN-7350HF Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 491
MSLN-8558HAF488 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 545
MSLN-8558HAF555 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 545
MSLN-8558HAF647 Recombinant Human MSLN Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 545
MSLN-8558HF Recombinant Human MSLN Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 545
MSLN-301H Active Recombinant Human MSLN, His-tagged Mammalian cells Human His 296-580 a.a.
Msln-32M Active Recombinant Mouse Msln protein, His-tagged CHO Mouse His Asp298-Ser600
Msln-33M Active Recombinant Mouse Msln protein, His-tagged HEK293 Mouse His Asp298-Gly582
MSLN-528H Active Recombinant Human MSLN Protein, Fc-tagged HEK293 Human Fc Glu296 - Ser592
MSLN-0382H Active Recombinant Human MSLN protein, His-Avi-tagged, Biotinylated HEK293 Human His&Avi 296-600 a.a.
MSLN-0383R Active Recombinant Rat MSLN protein, His-tagged HEK293 Rat His 298-600 a.a.
MSLN-0384M Active Recombinant Mouse MSLN protein, His-Avi-tagged, Biotinylated HEK293 Mouse His&Avi 298-600 a.a.
MSLN-0385C Recombinant Cynomolgus MSLN protein, His-tagged HEK293 Cynomolgus His Asp296-Gly580
MSLN-051H Active Recombinant Human MSLN protein, Fc/Avi-tagged, Biotinylated CHO cells Human Fc&Avi Glu296-Gly580
MSLN-15H Active Recombinant Human MSLN Protein, His-tagged, Alexa Fluor® 488 conjugated NS0 Human His 296-580 a.a.
MSLN-16H Active Recombinant Human MSLN Protein, His-tagged, Alexa Fluor® 647 conjugated NS0 Human His 296-580 a.a.
MSLN-2421M Recombinant Mouse MSLN protein, His-tagged HEK293 Mouse His Asp298-Ser600
MSLN-315H Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), His-tagged, FITC-Labeled HEK293 Human His Glu 296 - Gly 580
MSLN-5732C Recombinant Cynomolgus MSLN protein, His-tagged, Biotinylated(Primary Amine Labeling) HEK293 Cynomolgus His Asp296-Gly580
Msln-6743M Recombinant Mouse Msln protein, His-tagged, Biotinylated(Primary Amine Labeling) HEK293 Mouse His Asp298-Ser600
MSLN-7655C Recombinant Cynomolgus MSLN protein, hFc-tagged HEK293 Cynomolgus Fc Asp296-Gly580
MSLN-976HG Active GMP Recombinant Human MSLN protein HEK293 Human DNA sequence encoding Human MSLN(GenBank: AAH09272.1) was expressed with His tag at the C-terminal.
MSLN-10141M Recombinant Mouse MSLN Protein Mammalian Cell Mouse His
MSLN-10623H Recombinant Human MSLN protein, His-tagged, Biotin Labeled. HEK293 Human His Glu 296 - Gly 580
MSLN-185H Active Recombinant Human MSLN Protein, Fc-tagged HEK293 Human Fc
MSLN-2967H Recombinant Human MSLN, Fc Tagged, Biotinylated Human Cell Human Fc Glu296-Gly580
MSLN-302H Active Recombinant Human MSLN protein, His-tagged HEK293 Human His 296-580 a.a.
MSLN-340H Recombinant Human MSLN protein, Fc-tagged HEK293 Human Fc Glu296-Gly580
Msln-35M Recombinant Mouse Msln Protein, Fc-tagged HEK293 Mouse Fc Glu296 - Ser592
MSLN-3790R Recombinant Rat MSLN Protein Mammalian Cell Rat His
MSLN-491H Recombinant Human MSLN protein(Glu296-Gly580) HEK293 Human Non 296-580 a.a.
MSLN-7350H Recombinant Human MSLN, Fc tagged Human Cell Human Fc 1-286 a.a.
MSLN-7818H Recombinant Human MSLN protein, His-Avi-tagged HEK293 Human His&Avi Glu296-Gly580
MSLN-8558H Recombinant Human MSLN protein, hFc-tagged HEK293 Human Fc Glu296-Gly580
MSLN-8559H Recombinant Human MSLN protein, His-tagged HEK293 Human His Leu37-Arg286
MSLN-1316HCL Recombinant Human MSLN cell lysate Human Cell Human Non
MSLN-1343HCL Recombinant Human MSLN cell lysate Human Cell Human Non 296-580 a.a.
MSLN-006C Recombinant Cynomolgus MSLN Protein, Asp296-Gly580, C-His tagged, Biotinylated HEK293 Cynomolgus His Asp296-Gly580
MSLN-022H Recombinant Human mesothelin Protein, Tag Free HEK293 Human Non 550-598aa
MSLN-0379H Active Recombinant Human MSLN protein, His-tagged, Alexa Fluor 488-Labeled HEK293 Human His 296-580 a.a.
MSLN-0380H Active Recombinant Human MSLN protein, His-tagged, Alexa Fluor 647-Labeled HEK293 Human His 296-580 a.a.
MSLN-0381H Recombinant Human MSLN protein, His-tagged, Alexa Fluor 555-Labeled HEK293 Human His 296-580 a.a.
MSLN-0386M Active Recombinant Mouse MSLN protein, His-tagged HEK293 Mouse His 298-600 a.a.
MSLN-0387H Active Recombinant Human MSLN protein, Fc-tagged, FITC-Labeled HEK293 Human Fc 296-580 a.a.
MSLN-0388H Active Recombinant Human MSLN protein, Fc-tagged, FITC-Labeled HEK293 Human Fc 296-580 a.a.
MSLN-0389H Active Recombinant Human MSLN protein, Fc-tagged, Biotinylated HEK293 Human Fc 296-580 a.a.
MSLN-0390H Active Recombinant Human MSLN protein, His-tagged, Biotinylated HEK293 Human His 296-580 a.a.
MSLN-072H Recombinant Human MSLN Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
MSLN-09H Recombinant Human MSLN Protein, C-6His-Avi tagged, Biotinylated Human Cell Human His&Avi Glu296-Ser598
MSLN-10625HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Human Fc
MSLN-1139H Recombinant Human MSLN Protein, His-tagged HEK293F Human His Glu296-Ser606
MSLN-1339H Recombinant Human MSLN protein(Met1-Arg286), hFc-tagged HEK293 Human Fc Met1-Arg286
MSLN-151H Recombinant Human MSLN Protein, His-tagged Human cells Human His
MSLN-1538H Recombinant Human MSLN protein, His & GST-tagged E.coli Human His&GST Glu400~Leu615
Msln-1539M Recombinant Mouse Msln protein, His & GST-tagged E.coli Mouse His&GST Pro345~Asn548
MSLN-181H Recombinant Human MSLN Protein, His\Avi-tagged Human Cell Human His&Avi 296-598 a.a.
MSLN-185HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Human Fc
MSLN-185HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Human Fc
MSLN-2092H Recombinant Human MSLN Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
MSLN-2457H Recombinant Human MSLN Protein, His-tagged E.coli Human His Glu296-Ser606
MSLN-266H Recombinant Human MSLN protein, His-tagged, Biotinylated HEK293 Human His Met1-Arg286
Msln-267M Recombinant Mouse Msln Protein, Asp298-Ser600, C-His tagged, Biotinylated HEK293 Mouse His Asp298-Ser600
MSLN-317H Active Recombinant Human MSLN Protein (Glu 296 - Gly 580), His-tagged, GFP Fusion HEK293 Human His Glu 296 - Gly 580
MSLN-31H Recombinant Human MSLN Protein, His-tagged HEK293 Human His Glu296-Ser598
MSLN-3297H Recombinant Human MSLN protein(Glu296-Gly580), His-tagged HEK293 Human His Glu296-Gly580
MSLN-32H Recombinant Human MSLN Protein, Fc-tagged HEK293 Human Fc Glu296-Ser598
MSLN-340HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Human Fc
MSLN-340HB Recombinant Human MSLN Protein, hFc-tagged, Biotinylated HEK293 Human Fc Glu296-Gly580
MSLN-340HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Human Fc
MSLN-3449R Recombinant Rat MSLN Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
MSLN-3449R-B Recombinant Rat MSLN Protein Pre-coupled Magnetic Beads HEK293 Rat
MSLN-3527H Recombinant Human MSLN Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
MSLN-3527H-B Recombinant Human MSLN Protein Pre-coupled Magnetic Beads HEK293 Human
MSLN-380H Recombinant Human MSLN Protein, Fc-tagged, Biotinylated HEK293 Human Fc 630
MSLN-381H Recombinant Human MSLN Protein, His-tagged, Biotinylated HEK293 Human His 630
MSLN-382H Recombinant Human MSLN Protein, His-tagged HEK293 Human His 630
MSLN-383H Recombinant Human MSLN Protein, Fc-tagged HEK293 Human Fc 630
MSLN-384H Recombinant Human MSLN Protein, His-tagged HEK293 Human His 630
MSLN-3874H Recombinant Human MSLN Protein (Glu296-Gly580), C-His tagged Mammalian cells Human His Glu296-Gly580
MSLN-3875H Recombinant Human MSLN Protein (Glu296-Ser598), C-Fc tagged Mammalian cells Human Fc Glu296-Ser598
MSLN-3876H Recombinant Human MSLN Protein (Glu296-Ser598), C-His tagged Mammalian cells Human His Glu296-Ser598
MSLN-3877H Recombinant Human MSLN Protein (Leu37-Arg286), C-Fc tagged Mammalian cells Human Fc Leu37-Arg286
MSLN-3878H Recombinant Human MSLN Protein (Leu37-Arg286), C-His tagged Mammalian cells Human His Leu37-Arg286
MSLN-3880H Recombinant Human MSLN Protein (Glu296-Ser598), N-His tagged E.coli Human His Glu296-Ser598
MSLN-3881H Recombinant Human MSLN Protein (Glu310-Gly588), C-His tagged Mammalian cells Human His Glu310-Gly588
Msln-4191M Active Recombinant Mouse Msln Protein, His-tagged HEK293 Mouse His Asp298-Gly582
Msln-4192M Recombinant Mouse Msln Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
MSLN-4680H Active Recombinant Human MSLN Protein, His-tagged, APC-Labeled HEK293 Human His Glu 296 - Gly 580
MSLN-4681H Active Recombinant Human MSLN Protein, His-tagged, Site-specific APC-Labeled HEK293 Human His Glu 296 - Gly 580
MSLN-4682H Active Recombinant Human MSLN Protein, His-tagged, Site-specific PE-Labeled HEK293 Human His Glu 296 - Gly 580
MSLN-4684H Active Recombinant Human MSLN Protein, His-tagged, PE-Labeled HEK293 Human His Glu 296 - Gly 580
MSLN-5043H Recombinant Human MSLN protein, His-Myc-tagged HEK293 Human His&Myc 296-580aa
MSLN-528HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Human Fc
MSLN-528HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Human Fc
Msln-5473M Recombinant Mouse Msln protein, His-tagged Yeast Mouse His 298-600aa
MSLN-5659H Recombinant Human MSLN Protein, GST-tagged Wheat Germ Human GST
MSLN-5745M Recombinant Mouse MSLN Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
MSLN-5745M-B Recombinant Mouse MSLN Protein Pre-coupled Magnetic Beads HEK293 Mouse
MSLN-6461HF Recombinant Full Length Human MSLN Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 621 amino acids
MSLN-651H Recombinant Human MSLN Protein (Glu296-Gly580), C-mFc and 6×His-tagged HEK293 Human His&mFc Glu296-Gly580
MSLN-669M Recombinant Mouse MSLN Protein (298-600 aa), His-SUMO-tagged E.coli Mouse His&SUMO 298-600 aa
MSLN-7350HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Human Fc
MSLN-7350HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Human Fc
MSLN-75H Recombinant Human MSLN Protein, hFc-tagged HEK293 Human Fc
MSLN-7689M Active MSLN protein-coupled magnetic Beads HEK293 Human Glu 296 - Gly 580 (R309P)
MSLN-76H Recombinant Human MSLN Protein, His-tagged HEK293 Human His
MSLN-8558HA Recombinant Human MSLN protein, Fc-tagged, APC labeled HEK293 Human Fc
MSLN-8558HP Recombinant Human MSLN protein, Fc-tagged, R-PE labeled HEK293 Human Fc

    Involved Pathway

    MSLN involved in several pathways and played different roles in them. We selected most pathways MSLN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MSLN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    MSLN has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSLN itself. We selected most functions MSLN had, and list some proteins which have the same functions with MSLN. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PPP1R9A,C4orf33,HCST,CDKN2B,NDUFS7,MPPE1,ITGAM,EAF2,RECQL,TBC1D5

    Interacting Protein

    MSLN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSLN here. Most of them are supplied by our site. Hope this information will be useful for your research of MSLN.

    RSG1

    Resources

    Research Area

    CAR-T Cell Therapy Targets
    Tumor Antigens

    References

    • Samineni, D; Li, C; et al. PHARMACOKINETICS (PK) OF ANTI-MSLN ANTIBODY DRUG CONJUGATE (ADC) IN PATIENTS WITH UNRESECTABLE PANCREATIC OR PLATINUM-RESISTANT OVARIAN CANCER IN A PHASE I STUDY.. CLINICAL PHARMACOLOGY & THERAPEUTICS 97:S46-S46(2015).
    • Scales, SJ; Gupta, N; et al. An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models. MOLECULAR CANCER THERAPEUTICS 13:2630-2640(2014).

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