HGF

  • Official Full Name

    hepatocyte growth factor (hepapoietin A; scatter factor)

  • Overview

    Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing.

  • Synonyms

    SF;HGFB;HPTA;F-TCF;DFNB39;Fibroblast derived tumor cytotoxic factor;Hepatocyte growth factor;Hepatocyte growth factor beta chain;Hepatocyte growth factor precursor;Hepatopoeitin-A;Hepatopoietin A;Hgf;Lung fibroblast derived mitogen;OTTHUMP00000161349;OTTHUMP00000206710;OTTHUMP00000206711;OTTHUMP00000206712;OTTHUMP00000206713;OTTHUMP00000206730;Scatter factor;Rilotumumab;872514-65-3;Flanvotumab;1188277-05-5

Recombinant Proteins

  • Mouse
  • Dog
  • Human
  • Monkey
  • Rat
  • Cynomolgus
  • Canine
  • Chicken
  • Rabbit
  • Bovine
  • Pig
  • HEK293
  • Mammalian cells
  • CHO
  • Sf9 Insect Cell
  • Hi-5 Inscet Cell
  • CHO-K1
  • E.coli
  • Human Cell
  • Mammalian Cell
  • Insect Cell
  • Wheat Germ
  • Human
  • E. coli
  • NS0
  • HEK293T
  • Insects cell
  • Sf21 Insect Cell
  • Human cells
  • Pig Liver
  • Non
  • His
  • GST
  • His&Fc
  • Myc&DDK
  • Fc
  • His&T7
  • His&GST
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
Hgf-8665M Recombinant Mouse Hgf protein(Met1-Leu728) HEK293 Mouse Non 1-728 a.a.
HGF-1045CAF488 Recombinant Canine HGF Protein, Alexa Fluor 488 conjugated HEK293 Dog 699
HGF-1045CAF555 Recombinant Canine HGF Protein, Alexa Fluor 555 conjugated HEK293 Dog 699
HGF-1045CAF647 Recombinant Canine HGF Protein, Alexa Fluor 647 conjugated HEK293 Dog 699
HGF-1045CF Recombinant Canine HGF Protein, FITC conjugated HEK293 Dog 699
HGF-143HG Active GMP Recombinant Human HGF Protein Mammalian cells Human Non 32-728 a.a.
HGF-152CAF488 Recombinant Cynomolgus HGF Protein, None-tagged, Alexa Fluor 488 conjugated HEK293 Monkey Non 697
HGF-152CAF555 Recombinant Cynomolgus HGF Protein, None-tagged, Alexa Fluor 555 conjugated HEK293 Monkey Non 697
HGF-152CAF647 Recombinant Cynomolgus HGF Protein, None-tagged, Alexa Fluor 647 conjugated HEK293 Monkey Non 697
HGF-152CF Recombinant Cynomolgus HGF Protein, None-tagged, FITC conjugated HEK293 Monkey Non 697
Hgf-8664MAF488 Recombinant Mouse Hgf Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His 707
Hgf-8664MAF555 Recombinant Mouse Hgf Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His 707
Hgf-8664MAF647 Recombinant Mouse Hgf Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His 707
Hgf-8664MF Recombinant Mouse Hgf Protein, His-tagged, FITC conjugated HEK293 Mouse His 707
Hgf-8665MAF488 Recombinant Mouse Hgf Protein, None-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Non 696
Hgf-8665MAF555 Recombinant Mouse Hgf Protein, None-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Non 696
Hgf-8665MAF647 Recombinant Mouse Hgf Protein, None-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Non 696
Hgf-8665MF Recombinant Mouse Hgf Protein, None-tagged, FITC conjugated HEK293 Mouse Non 696
HGF-872HAF488 Recombinant Human HGF Protein, None-tagged, Alexa Fluor 488 conjugated CHO Human Non 697
HGF-872HAF555 Recombinant Human HGF Protein, None-tagged, Alexa Fluor 555 conjugated CHO Human Non 697
HGF-872HAF647 Recombinant Human HGF Protein, None-tagged, Alexa Fluor 647 conjugated CHO Human Non 697
HGF-872HF Recombinant Human HGF Protein, None-tagged, FITC conjugated CHO Human Non 697
Hgf-8806RAF488 Recombinant Rat Hgf Protein, None-tagged, Alexa Fluor 488 conjugated HEK293 Rat Non 698
Hgf-8806RAF555 Recombinant Rat Hgf Protein, None-tagged, Alexa Fluor 555 conjugated HEK293 Rat Non 698
Hgf-8806RAF647 Recombinant Rat Hgf Protein, None-tagged, Alexa Fluor 647 conjugated HEK293 Rat Non 698
Hgf-8806RF Recombinant Rat Hgf Protein, None-tagged, FITC conjugated HEK293 Rat Non 698
HGF-195H Active Recombinant Human HGF protein HEK293 Human Non
HGF-290H Active Recombinant Human HGF Sf9 Insect Cell Human Non
HGF-501H Active Recombinant Human HGF Hi-5 Inscet Cell Human Non
HGF-6H Active Recombinant Human HGF Hi-5 Inscet Cell Human Non
Hgf-728M Active Recombinant Mouse Hepatocyte Growth Factor, His-tagged Mammalian cells Mouse His 1-653 a.a.
Hgf-734M Active Recombinant Mouse Hepatocyte Growth Factor Mammalian cells Mouse Non 33-495;496-728 a.a.
HGF-8535H Active Recombinant Human HGF CHO Human Non 1-728 a.a.
HGF-01HG Active GMP Recombinant Human HGF Protein CHO-K1 Human
HGF-146C Active Recombinant Cynomolgus HGF protein HEK293 Cynomolgus Non Met1-Ser728
HGF-2847H Recombinant Human HGF protein, For Organoid Culture HEK293 Human Non Gln28-Cys232
HGF-3402M Active Recombinant Mouse HGF protein(Met1-Leu728) HEK293 Mouse Non Met1-Leu728
HGF-1045C Recombinant Canine HGF protein(Met1-Ser730) HEK293 Canine Non 1-730 a.a.
Hgf-1237R Recombinant Rat Hgf Protein, GST-tagged E.coli Rat GST 477-728 a.a.
HGF-123H Recombinant Human Hepatocyte Growth Factor (Hepapoietin A; Scatter factor) CHO Human Non
HGF-152C Recombinant Cynomolgus HGF, None tagged Human Cell Cynomolgus His&Fc 1-728 a.a.
HGF-2239C Recombinant Chicken HGF Mammalian Cell Chicken His
HGF-225H Recombinant Human HGF E.coli Human Non 32-285aa
HGF-226H Recombinant Human HGF, 495-728aa, His-tagged E.coli Human His 495-728 a.a.
HGF-254H Recombinant Human HGF Protein, MYC/DDK-tagged HEK293 Human Myc&DDK This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.
Hgf-257M Recombinant Mouse Hgf Protein Insect Cell Mouse Non
HGF-27731TH Recombinant Human HGF, His-tagged E.coli Human His Full L. 32-494 a.a.
HGF-2836R Recombinant Rat HGF Protein Mammalian Cell Rat His
HGF-341H Recombinant Human HGF Mammalian cells Human Non
HGF-364H Recombinant Human HGF, His tagged Human Cell Human His 1-728 a.a.
HGF-4726H Recombinant Human HGF Protein E.coli Human Non 32-494 a.a.
HGF-4728H Active Recombinant Human HGF Protein Insect Cell Human Non
HGF-4729H Recombinant Human HGF Protein, GST-tagged Wheat Germ Human GST
Hgf-4731M Active Recombinant Mouse Hgf Protein Insect Cell Mouse Non Full L.
HGF-543H Recombinant Human Hepatocyte Growth Factor Insect Cell Human Fc
HGF-592H Recombinant Human Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor) HEK293 Human Non
HGF-593H Recombinant Human HGF, His-tagged HEK293 Human His 1-728 a.a.
Hgf-599M Recombinant Mouse Hgf Insect Cell Mouse Non 1-728 a.a.
HGF-627H Recombinant Human Hepatocyte Growth Factor Human Human Non
HGF-791D Recombinant Dog HGF protein, His & T7-tagged E.coli Dog His&T7 Val495~Ser730
HGF-792H Recombinant Human HGF protein, His-tagged E. coli Human His Val495~Ser728
HGF-793H Recombinant Human HGF protein, His & GST-tagged E.coli Human His&GST Gln32~Asn291
Hgf-794M Recombinant Mouse Hgf protein, His-tagged E.coli Mouse His Asp482~Val710
Hgf-795R Recombinant Rat Hgf protein, His-tagged E.coli Rat His Cys306~Glu471
HGF-796R Recombinant Rabbit HGF protein, His & T7-tagged E.coli Rabbit His&T7 Gln32~Arg494
Hgf-8664M Active Recombinant Mouse Hgf protein(Met1-Leu728), His-tagged HEK293 Mouse His Met1-Leu728
HGF-872H Recombinant Human HGF, None tagged CHO Human Non 1-728 a.a.
Hgf-8806R Recombinant Rat Hgf protein(Met1-Leu728) HEK293 Rat Non 1-728 a.a.
HGF-001HCL Recombinant Human HGF cell lysate CHO Human Non
HGF-1077CCL Recombinant Cynomolgus HGF cell lysate Human Cell Cynomolgus Non
HGF-1210MCL Recombinant Mouse HGF cell lysate Human Cell Mouse Non
HGF-1233RCL Recombinant Rat HGF cell lysate Human Cell Rat Non
HGF-01H Active Recombinant Human HGF Protein HEK293 Human
HGF-03B Active Recombinant Bovine HGF Protein, NK1 isoform, Animal-Free E. coli Bovine
HGF-05HG Active Recombinant Human HGF Protein (Gln32-Ser728, Asp384Asn, Asp416Asn, Leu622Ser, His645Arg, Val678Ile), GMP Grade NS0 Human Gln32-Ser728, Asp384Asn, Asp416Asn, Leu622Ser, His645Arg, Val678Ile
Hgf-072M Active Recombinant Mouse Hgf Protein Insect Cell Mouse
Hgf-073M Recombinant Mouse Hgf Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
HGF-1067H Recombinant Human HGF Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
HGF-1067H-B Recombinant Human HGF Protein Pre-coupled Magnetic Beads HEK293 Human
HGF-114H Recombinant Active Human HGF Protein, Tag Free HEK293 Human Non
HGF-115H Recombinant Active Human HGF Protein, Tag Free Insects cell Human Non
HGF-13H Active Recombinant Human HGF Propeptide Protein Insect Cell Human Non 32-728 a.a.
HGF-142H Recombinant Human hepatocyte growth factor Protein, Flag tagged HEK293 Human Flag 32-728aa
HGF-144HG GMP Recombinant Human HGF Protein, His-tagged HEK293 Human His DNA sequence encoding Human HGF(P14210) was expressed with His tag at the C-terminal.
HGF-157H Human Hepatocyte Growth Factor(precursor, rDNA derived) Reference standard Sf21 Insect Cell Human Non
HGF-158H Human Hepatocyte Growth Factor(rDNA derived) Reference standard CHO Human Non
HGF-18H Active Recombinant Human HGF Protein, Animal Free Human cells Human
HGF-20H Recombinant Human HGF Protein E.coli Human
HGF-210H Recombinant Human HGF protein, Fc-tagged HEK293 Human Fc Gln32-Ser728
HGF-232P Native Porcine HGF Pig Liver Pig Non
HGF-2491R Recombinant Rat HGF Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
HGF-2491R-B Recombinant Rat HGF Protein Pre-coupled Magnetic Beads HEK293 Rat
HGF-2495H Recombinant Human HGF protein, His-tagged HEK293 Human His Gln32-Ser728
HGF-2496H Recombinant Human HGF Protein (Tyr28-Val209), N-His tagged E.coli Human His Tyr28-Val209
HGF-251H Recombinant Human hepatocyte growth factor Protein, Tag Free HEK293 Human Non 32-728aa
HGF-267H Active Recombinant Human HGF Protein CHO Human α-chain: 463 amino acid<br />β-chain: 234 amino acid
HGF-29231TH Native Human HGF Human Non
HGF-322B Recombinant Bovine HGF protein(32-494aa), His-tagged E.coli Bovine His 32-494aa
HGF-38P Native Porcine HGF Pig Liver Pig Non
Hgf-4147M Recombinant Mouse Hgf Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Hgf-4147M-B Recombinant Mouse Hgf Protein Pre-coupled Magnetic Beads HEK293 Mouse
HGF-4235H Recombinant Human HGF Protein (Gln31-Ser723), C-His tagged Mammalian cells Human His Gln31-Ser723
HGF-5037H Recombinant Human HGF Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
HGF-607HFL Active Recombinant Full Length Human HGF Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
HGF-790H Recombinant Human HGF protein, His-tagged E. coli Human His Gly221-Leu440
HGF-963H Recombinant Human HGF Protein, GST-tagged E.coli Human GST Gln32-Asn291
HGF-9876B Recombinant Bovine HGF protein, His-tagged E.coli Bovine His 32-494a.a.

    Involved Pathway

    HGF involved in several pathways and played different roles in them. We selected most pathways HGF participated on our site, such as Ras signaling pathway,Rap signaling pathway,Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Malaria VCAM1,GYPC,CCL2,Ccl12,CD40,KLRK1,IL1B,HBA-A2,TGFB3,ITGAL
    Cytokine-cytokine receptor interaction IL15,INHBB,GM13306,IFNB1,IL28RA,KIT,CXCL11,VEGFAA,CCL28,CXCR3.2
    Melanoma BAD,PTEN,RB1,FGFR1,TRP53,IGF1R,FGF18,PIK3CG,PIK3R2,RAF1
    Pathways in cancer GNG8,WNT7A,LAMA2,FOXO1,HDAC2,LPAR5,ETS1,PML,IKBKB,VHL
    PIK-Akt signaling pathway OSMR,PKN3,HSP90B1,INS,GNG8,LAMA3,VEGFA,GNG12,MDM2,GNGT1
    Ras signaling pathway CSF1,RASGRF2,FGF18,FGF3,GNG13,FGF7,VEGFC,BRAP,FGF2,VEGFB
    Proteoglycans in cancer RPS6KB1,ANK1,ACTG1,HOXD10,CAMK2A,PRKACG,WNT9A,MAPK11,MDM2,RPS6
    Renal cell carcinoma CDC42,PIK3CB,FH1,TGFB2,VEGFA,TCEB2,PIK3CG,PIK3CD,RAF1,EPAS1
    Rap signaling pathway MRAS,Itgam&Itgb2,RALGDS,RAPGEF6,PLCE1,FPR1,KIT,FGF14,DOCK4,PLCB2

    Protein Function

    HGF has several biochemical functions, for example, chemoattractant activity,growth factor activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGF itself. We selected most functions HGF had, and list some proteins which have the same functions with HGF. You can find most of the proteins on our site.

    Function Related Protein
    chemoattractant activity FGF8,CCL16,FIGF,SAA2,VEGFB,CCL5,VEGFC,CXCL12A,FGF10,MIF
    growth factor activity Pdgfa&Pdgfb,CXCL1,LEFTY2,OSM,FGF8,GSDF,CLCF1,GDF5,NDR2,PDGFB
    serine-type endopeptidase activity PRSS22,Gzmg,F2,LOC780933,HABP2,MASP1,KLK1B8,MBTPS1,PIK3IP1,PRSS44
    protein binding CASC3,PSMD11,EXOSC1,LPL,ZNF624,GPC3,KRTAP10-4,SYVN1,CTCFL,KANK2
    identical protein binding STK4,CEP72,ENTPD2,PLN,PRKAB2,TRIM23,GCC2,TPRGL,CHAF1A,FAS
    NOT serine-type endopeptidase activity RHBDF1,RHBDF2
    protein heterodimerization activity XBP1,TGFB2,PVALB,TYRO3,INHBA,PRPH,CLNS1A,IKBKG,CLCN3,HIST1H3A

    Interacting Protein

    HGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HGF.

    MET;MEOX2;Met;ADAMTSL4;SRPX2;Hgf;FN1;CD44

    Resources

    Gene Families

    Growth Factors

    Research Area

    Cancer Drug Targets
    Other Cytokines & Receptors
    Angiogenic Activator
    EMT Induction
    Semaphorins, Plexin Receptors, and Related Molecules
    Angiogenic Activator in Cancer

    References

    • Pena-Silva, RA; Chalouhi, N; et al. Novel Role for Endogenous Hepatocyte Growth Factor in the Pathogenesis of Intracranial Aneurysms. HYPERTENSION 65:587-593(2015).
    • Wang, YQ; Fukuda, T; et al. Loss of alpha 1,6-fucosyltransferase suppressed liver regeneration: implication of core fucose in the regulation of growth factor receptor-mediated cellular signaling. SCIENTIFIC REPORTS 5:-(2015).

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