Recombinant Human UNG Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: UNG-2871H
• Product Overview: UNG MS Standard C13 and N15-labeled recombinant protein (NP_550433) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 34.5 kDa
• AA Sequence: MIGQKTLYSFFSPSPARKRHAPSPE PAVQGTGVAGVPEESGDAAAIPAKK APAGQEEPGTPPSSPLSAEQLDRIQ RNKAAALLRLAARNVPVGFGESWKK HLSGEFGKPYFIKLMGFVAEERKHY TVYPPPHQVFTWTQMCDIKDVKVVI LGQDPYHGPNQAHGLCFSVQRPVPP PPSLENIYKELSTDIEDFVHPGHGD LSGWAKQGVLLLNAVLTVRAHQANS HKERGWEQFTDAVVSWLNQNSNGLV FLLWGSYAQKKGSAIDRKRHHVLQT AHPSPLSVYRGFFGCRHFSKTNELL QKSGKKPIDWKELTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: UNG uracil-DNA glycosylase [ Homo sapiens (human) ]
• Official Symbol: UNG
• Synonyms: UNG; uracil-DNA glycosylase; DGU; HIGM4; UDG; UNG1; UNG2; uracil DNA glycosylase 1; uracil DNA glycosylase 2; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; UNG15; DKFZp781L1143
• Gene ID: 7374
• mRNA Refseq: NM_080911
• Protein Refseq: NP_550433
• MIM: 191525
• UniProt ID: P13051

Reviews

09/22/2022

The technician guided me through the process, which led to satisfactory results.

07/14/2022

The UNG protein product received was as advertised, top quality and good value for money.

05/04/2022

Prompt delivery helped me get satisfactory experimental results in a short period of time.

Q&As

What biological processes are UNG involved in?

UNG is involved in DNA repair, base excision repair and apoptosis.

Where is UNG located?

UNG is localized in the nucleus, nucleoplasm, and mitochondria.

What protein does UNG shear to produce?

UNG can be sheared to produce UNG1 and UNG2.

Where is UNG primarily expressed?

UNG is mainly expressed in testis, thymus and skeletal muscle.