UNG

  • Product List
  • Overview
  • Review / Q&A
  • Official Full Name

    uracil-DNA glycosylase
  • Overview

    This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
  • Synonyms

    UNG;uracil-DNA glycosylase;DGU;UDG;UNG1;UNG2;HIGM4;HIGM5;UNG15;uracil-DNA glycosylase 1, uracil-DNA glycosylase 2

Recombinant Proteins

  • Human
  • E.coli
  • Bacillus subtilis
  • Mouse
  • Chicken
  • Rat
  • E.coli
  • E.Coli/Yeast
  • Mammalian Cells
  • HEK293
  • Non
  • GST
  • His
  • DDK
  • Myc
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UNG-1547H Recombinant Human UNG protein E.coli Human Non Full L.
UNG-3600H Recombinant Human UNG, GST-tagged E.coli Human GST 1-304aa
ung-61E Active Recombinant E. coli Uracil DNA Glycosylase E.coli E.coli Non
UNG-0803B Recombinant Bacillus subtilis UNG protein, His-tagged E.Coli/Yeast Bacillus subtilis His
ung-1546E Recombinant E.coli ung protein E.coli E.coli Non
UNG-17856M Recombinant Mouse UNG Protein Mammalian Cells Mouse His
UNG-2559H Recombinant Human UNG protein, GST-tagged E.coli Human GST Phe85-Leu304
ung-282E Recombinant E.coli uracil-DNA-glycosylase, His-tagged E.coli E.coli His 1-229 a.a.
UNG-3601H Recombinant Human UNG protein, His-tagged E.coli Human His Met1~Leu313
UNG-5763C Recombinant Chicken UNG Mammalian Cells Chicken His
UNG-497HCL Recombinant Human UNG 293 Cell Lysate HEK293 Human Non
UNG-498HCL Recombinant Human UNG 293 Cell Lysate HEK293 Human Non
UNG-02H Recombinant Human UNG Protein, C-Myc/DDK-Tagged HEK293 Human DDK&Myc
UNG-1019HFL Recombinant Full Length Human UNG Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
UNG-2317H Recombinant Human UNG Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
UNG-2317H-B Recombinant Human UNG Protein Pre-coupled Magnetic Beads HEK293 Human
UNG-2871H Recombinant Human UNG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
UNG-6544H Recombinant Human UNG Protein (Ala45-Leu313), N-His tagged E.coli Human His Ala45-Leu313
Ung-6842M Recombinant Mouse Ung Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
ung-8332E Native E.coli ung E.coli Rat Non
UNG-9922M Recombinant Mouse UNG Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
UNG-9922M-B Recombinant Mouse UNG Protein Pre-coupled Magnetic Beads HEK293 Mouse

Involved Pathway

UNG involved in several pathways and played different roles in them. We selected most pathways UNG participated on our site, such as Base excision repair,Primary i,nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with UNG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Primary i DCLRE1C,IL7R,BLNK,PTPRC,TAP2, Cd79b,RFXAP,CD19,CD79A,CD40LG
nodeficiency Cd79b,TNFRSF13B,CD3D,BTK,ICOS,CD40,IL7R,TAP2,CD79A,AIRE
Base excision repair APEX1,UNGA,POLE3,MBD4,LIG1,MUTYH,PCNA,SMUG1,OGG1,nth

Protein Function

UNG has several biochemical functions, for example, damaged DNA binding,protein binding,uracil DNA N-glycosylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UNG itself. We selected most functions UNG had, and list some proteins which have the same functions with UNG. You can find most of the proteins on our site.

Function Related Protein
damaged DNA binding RPA2,MPG,GTF2H3,FEN1,NEIL3,RAD1,POLK,NEIL1,PNKP,TRP63
protein binding TARDBP,MAPK1,CLK3,SLC25A6,C1orf189,FAM126B,CPSF6,FZR1,KRT20,ZNF131
uracil DNA N-glycosylase activity TDG,TDG.1,APEX1,CCNO,SMUG1,UNGA

Interacting Protein

UNG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UNG here. Most of them are supplied by our site. Hope this information will be useful for your research of UNG.

RPA2;UGI;4505953;vpr;SEZ6L2;CAPN11;vpr;k7_vaccw;Ppp2r2d;vpr

Resources

Research Area

Base Excision Repair

References

  • Pettersen, HS; Galashevskaya, A; et al. AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. DNA REPAIR 25:60-71(2015).
  • White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).

Ask a Question for All UNG Products

Required fields are marked with *

My Review for All UNG Products

Required fields are marked with *