TSLP
-
Official Full Name
thymic stromal lymphopoietin -
Overview
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants. -
Synonyms
TSLP;Thymic Stromal Lymphopoietin;Thymic stromal lymphopoietin Precursor
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rat
- White-tufted-ear marmoset
- Rabbit
- Insect cell
- HEK293
- Insect Cell
- Mammalian cells
- Mammalian Cell
- E.coli
- Human Cell
- Mouse
- His
- His&Avi
- Fc
- Non
- FC
- His&T7
- LEAF
- mFc
- His&SUMO
- His&Fc&Avi
- His&GST
- N-His-SUMO
Involved Pathway
TSLP involved in several pathways and played different roles in them. We selected most pathways TSLP participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TSLP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | FHL1,IFNA7,PIK3R1,STAT1,GRB2A,IL6R,PRL,IL29,PIK3R3B,AKT2 |
| Cytokine-cytokine receptor interaction | KIT,IFNGR1,CCL6,PRL,CSF3,CCL3L1,IL7,BMP7B,CCL28,Il4ra |
Protein Function
TSLP has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TSLP itself. We selected most functions TSLP had, and list some proteins which have the same functions with TSLP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | THPO,TNFSF18,FLT3LG,TIMP1,GM13289,HMGB1,GM13279,Il23a; Il12b,IL13,Cxcl15 |
Interacting Protein
TSLP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TSLP here. Most of them are supplied by our site. Hope this information will be useful for your research of TSLP.
PRNP;IKBKG
Resources
Research Area
Other Cytokines & ReceptorsMultiple Sclerosis and Myelin Related Molecules
Cytokines and Chemokines in B Cell Development
Th2 Cells
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References
- McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
- Biedermann, T; Werfel, T; et al. Status quo and prospects for systemic therapy of atopic dermatitis. Biologics ante portas. HAUTARZT 66:108-113(2015).
