THPO
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Official Full Name
thrombopoietin -
Overview
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5 UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014] -
Synonyms
THPO;thrombopoietin;ML;TPO;MGDF;MKCSF;MPLLG;THCYT1;MPL ligand;c-mpl ligand;prepro-thrombopoietin;megakaryocyte stimulating factor;megakaryocyte colony-stimulating factor;megakaryocyte growth and development factor;myeloproliferative leukemia virus oncogene ligand
Recombinant Proteins
- Human
- Mouse
- Bovine
- Cynomolgus
- Chicken
- Rat
- Zebrafish
- Porcine
- CHO
- HEK293
- Yeast
- E.coli
- Mammalian Cells
- Sf21 Cells
- Human Cells
- His
- Non
- Fc
- GST&His
- His&T7
- Avi&Fc&His
- His&MBP
- His&SUMO
- GST
Involved Pathway
THPO involved in several pathways and played different roles in them. We selected most pathways THPO participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with THPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNA21,M17,GHR,IL4R,IL5,IFNB,IFNA12,PF4V1,CXCL1,LOC100033925 |
| Hematopoietic cell lineage | IL5RA,CD3E; CD3D, B2M,HLA-DRB3,FCGR1A,ITGA2,KIT,Kitl,CD1D,GP5 |
| Jak-STAT signaling pathway | STAT4,IFNA5,Ifna15,SOCS3,STAT1,PIM1,HRAS,IFNA21,PIK3CA,CSH2 |
Protein Function
THPO has several biochemical functions, for example, cytokine activity,growth factor activity,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by THPO itself. We selected most functions THPO had, and list some proteins which have the same functions with THPO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IL1RN,IL36B,SECTM1,CCL4,Il1f9,CER1,WNT5A,MSTN,GDF6,IL17C |
| growth factor activity | HBEGFA,FGF13A,FIGF,FGF6,GH1,TIMP1,CXCL12,VHL,IL34,MDKB |
| hormone activity | PRL7A2,CRHB,UCN2,IFNT2,NMB,CRH,POMC,PRL7A1,UCN3L,GCGB |
Interacting Protein
THPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THPO here. Most of them are supplied by our site. Hope this information will be useful for your research of THPO.
EP300;APH1A;NUMBL
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References
- Kuter, DJ; et al. Milestones in understanding platelet production: a historical overview. BRITISH JOURNAL OF HAEMATOLOGY 165:248-258(2014).
- Arai, F; Yoshihara, H; et al. Niche Regulation of Hematopoietic Stem Cells in the Endosteum The Role of Thrombopoietin/Mp1 Signaling in the Maintenance of Quiescent Hematopoietic Stem Cells. HEMATOPOIETIC STEM CELLS VII 1176:36-46(2009).
