PGAM1
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Official Full Name
phosphoglycerate mutase 1 (brain) -
Overview
Phosphoglyceric acid mutase (EC 2.7.5.3) is widely distributed in mammalian tissues where it catalyzes the reversible;reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway (summary by Chen et;al., 1974 (PubMed 4811757)). -
Synonyms
PGAM1;phosphoglycerate mutase 1 (brain);PGAMA;phosphoglycerate mutase 1;PGAM B;Phosphoglycerate mutase A;nonmuscle form;BPG-dependent PGAM 1;phosphoglycerate mutase isozyme B;phosphoglycerate mutase A, nonmuscle form;PGAM-B
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cells
- In Vitro Cell Free System
- His
- GST
- DDK
- Myc
- Non
- Strep
- Flag
- Avi
- Fc
Involved Pathway
PGAM1 involved in several pathways and played different roles in them. We selected most pathways PGAM1 participated on our site, such as Glycolysis / Gluconeogenesis,Glycine, serine and threonine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | PGAM2,PCK2,ADH4,FBP1,GPI1,ALDH2.2,TPI1,ENO1,ENO1B,PDHB |
| Glycine, serine and threonine metabolism | GAMT,ALAS2,ALDH7A1,ALAS1,GCAT,PGAM2,GATM,THA1,DAO.1,GNMT |
| Biosynthesis of amino acids | GLULB,PSAT1,CBS,ASL,PHGDH,SHMT1,ASL2,CPS1,ALDOC,PYCR1B |
| Metabolic pathways | CMPK2,NDUFA1,NME3,UQCRFS1,HAL,FDPS,DGKAA,ALPI.1,B4GALT2,LDHBB |
| Carbon metabolism | SDHB,MTHFR,HK2,AMT,PCCA,PGK1,SHMT2,PGP,PKM2,PRPS1A |
| Central carbon metabolism in cancer | PDK1,PDHA1,NTRK1,RET,PIK3R3,PKM2,KIT,MAP2K2,NRAS,G6PD |
Protein Function
PGAM1 has several biochemical functions, for example, bisphosphoglycerate 2-phosphatase activity,bisphosphoglycerate mutase activity,catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGAM1 itself. We selected most functions PGAM1 had, and list some proteins which have the same functions with PGAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoglycerate mutase activity | PGAM2,PGAM1B,PGAM1A,BPGM |
| isomerase activity | ITPK1,HMGCS1,PPIAA,TPI1A,GPIB,PBLD1,ITPK1A,GSBP9,ECI2,FKBP10B |
| hydrolase activity | HDAC9B,Gzmg,SACM1LB,TDRD12,PPP1CBL,PPP4CB,ATP13A,PLCD3A,DHX34,CHD8 |
| bisphosphoglycerate mutase activity | BPGM,PGAM2 |
| protein kinase binding | CCNT2B,KIF13B,CEP68,ERRFI1,IKBKB,IBTK,FGFR1OP,LLGL1,SKAP1,MAP3K1 |
| catalytic activity | PKM,PNP5A,ACSM2,LYZ2,CPS1,MOXD2,SLC27A2A,MDH1AA,HOGA1,LYZ1 |
| bisphosphoglycerate 2-phosphatase activity | PGAM2,C12orf5,TIGARA,BPGM,TIGARB |
| intramolecular transferase activity, phosphotransferases | BPGM,PGAM1B,PGAM1A |
Interacting Protein
PGAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PGAM1.
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